Effects of dietary supplementation with fish oil on dry eye syndrome subjects: randomized controlled trial
Open accessAbstract
The purpose of this study was to evaluate the efficacy of fish oil supplementation added to usual dry eye treatment in dry eye subjects in a randomized controlled trial. Twenty-seven typical dry eye subjects were selected from 43 candidates by the diagnostic criterion for dry eye in this study. They were assigned to the randomized fish oil group (n = 15) or the placebo group (n = 12). Fish oil group ingested fish oil capsules containing eicosapentaenoic acid (EPA, 1245 mg/day) and docosahexaenoic acid (DHA, 540 mg/day) for 12 weeks. Placebo group ingested placebo capsules without EPA or DHA. A visual analog scale test estimating subjective symptoms, the Schirmer I test, tear film break-up time (BUT) measurement, fluorescein staining, and rose bengal staining were performed every 4 weeks during the 12-week supplementation period and 4-week washout period. The subjective symptom of "eye pain", BUT, and changes in rose bengal staining score of the fish oil group were significantly improved after 8-12 weeks of supplementation and/or 4 weeks of washout, compared to those of the placebo group. These results suggest that fish oil supplementation added to usual care may be effective in the treatment of dry eye.
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Most previous randomized, placebo-controlled trials of n-3 fatty acids for dry eye disease showed significantly greater improvement in symptoms or in at least one sign in the n-3 group than in the placebo group.
“Most of these trials showed significantly greater improvement in symptoms or in at least one of several signs of dry eye disease in the n–3 fatty acid group than in the placebo group.15,18–22,24,26”
From n−3 Fatty Acid Supplementation for the Treatment of Dry Eye Disease (2018) · cites this paper as [22]
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Research works printed but not linked: 2
- Lemp MA and Foulks GN (2007) The definition and classifi- cation of dry eye disease: report of the Definition and Classi- fication Subcommittee of the International Dry Eye WorkShop (2007). Ocul Surf 5, 75-92.
- Nichols KK, Foulks GN, Bron AJ, Glasgow BJ, Dogru M, Tsubota K, Lemp MA and Sullivan DA (2011) The interna- tional workshop on meibomian gland dysfunction: executive summary. Invest Ophthalmol Vis Sci 52, 1922-1929.
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n−3 Fatty Acid Supplementation for the Treatment of Dry Eye Disease
The Dry Eye Assessment and Management Study Research Group (2018) · New England Journal of Medicine · doi:10.1056/nejmoa1709691 · Cited by 274 · see citing works
- Authors
- KAWAKITA, T., KAWABATA, F., TSUJI, T., KAWASHIMA, M., SHIMMURA, S., & TSUBOTA, K.
- Affiliations
- Keio University (JP)
- Nippon Suisan Kaisha (Japan) (JP)
- Venue
- Biomedical Research
- Publisher
- Biomedical Research Press
- Published
- 2013
- Volume
- 34
- Issue
- 5
- Pages
- 215-220
- ISSN
- 0388-6107 (ISSN-L)
- 1880-313X
- OpenAlex
- W1975973163
- Cited by
- 48
- References
- 0
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 4 · 2023: 5 · 2022: 3 · 2021: 3 · 2020: 4 · 2019: 6 · 2018: 5 · 2017: 6 · 2016: 4 · 2014: 2
- FWCI
- 1.84
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Biomedical Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Ocular Surface and Contact Lens
- Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
- Health Sciences › Medicine › Ophthalmology › Retinal Diseases and Treatments
- Keywords
- dry eye, fish oil supplementation, eicosapentaenoic acid, docosahexaenoic acid, omega-3 fatty acids, tear film break-up time, Schirmer test, rose bengal staining, fluorescein staining, ocular pain, tear film
- MeSH terms
- Female, Fish Oils, Humans, Male, Middle Aged, Time Factors, Dry Eye Syndromes, Case-Control Studies, Treatment Outcome, Dietary Supplements
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