The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
The Immune Interactions of Gut Glycans and Microbiota in Health and Disease
Open accessPreprint — published as 10.1111/mmi.15267
Abstract
The human digestive system harbors a vast diversity of commensal bacteria and maintains a symbiotic relationship with them. However, imbalances in the gut microbiota, known as dysbiosis, accompany various diseases, such as inflammatory bowel diseases (IBDs) and colorectal cancers (CRCs), which have a significant impact on the well-being of people globally. Glycosylation of the mucus layer is a key factor that plays a critical role in maintaining the homeostatic environment in the gut. This review delves into the ways in which the gut microbiota, gut epithelial barrier, and immune cells work together to establish a balanced gut environment. Specifically, the role of glycosylation in regulating immune cell responses and mucus metabolism in this process is examined. Additionally, the review explores various modulatory approaches used to maintain or restore the functional gut microbiota.
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Cites
Highly accurate protein structure prediction with AlphaFold
Jumper, J., Evans, R., Pritzel, A., Green, T., Figurnov, M., Ronneberger, O., Tunyasuvunakool, K., Bates, R., Žídek, A., Potapenko, A., et al. (2021) · Nature · doi:10.1038/s41586-021-03819-2 · Cited by 43,764
Metadata
- Authors
- Demirturk, M., Cinar, M. S., & Avci, F. Y.
- Affiliations
- Emory University (US)
- Corresponding author
- Avci, Fikri Y.
- Venue
- Molecular Microbiology
- Publisher
- Wiley
- Published
- 2023-10-15
- Volume
- 122
- Issue
- 3
- Pages
- 313-330
- ISSN
- 0950-382X (ISSN-L)
- OpenAlex
- W4396644307
- Cited by
- 14
- References
- 1
- Citations by year
- 2026: 8 · 2025: 3 · 2024: 3
- FWCI
- 0.57
- Type
- journal article
- Language
- en
- Open access
- green
- doi.org
- Locations
- Molecular Microbiology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (publishedVersion)
- Funders
- National Institutes of Health
- National Institute of Allergy and Infectious Diseases (R41AI157287, R01AI123383, R01AI152766)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Glycosylation and Glycoproteins Research
- Health Sciences › Medicine › Gastroenterology › Inflammatory Bowel Disease
- Keywords
- gut microbiota, mucus glycosylation, commensal bacteria, inflammatory bowel disease, colorectal cancer, immune cell response, intestinal homeostasis
- MeSH terms
- Gastrointestinal Microbiome, Animals, Bacteria, Glycosylation, Homeostasis, Humans, Intestinal Mucosa, Mucus, Polysaccharides, Colorectal Neoplasms, Inflammatory Bowel Diseases
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