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Cited by 42Parasitic Diseases Research and TreatmentHelminth infection and controlParasites and Host Interactions

The DOI matches its Crossref record; 16 of the 16 references it cites were found in a registry or an index.

Efficacy of Mebendazole and Albendazole against Trichinella spiralis in Mice

McCracken, Richard O.·1978·The Journal of Parasitology
DOI 10.2307/3279659
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Abstract

Changes in the sensitivity of Trichinella spiralis to anthelmintic treatment during the first 3 days of infection in mice were studied. Oral administration of either mebendazole or albendazole at 6.25 mh/kg 2 hr after exposure to infection eliminated 95-100% of the worms as determined at necropsy on day 7 postinoculation. Beyond the first day of infection the sensitivity of the parasite to benzimidazole therapy was much reduced and an oral dose of 50 mg/kg was only partially but significantly active against the adult worms. Despite decline in drug sensitivity during the enteral phase, gavage administration of either mebendazole or albendazole at 50 mg/kg for 5 consecutive days during the invasive phase of infection significantly reduced (96 and 67%, respectively) the number of larvae subsequently recovered from host musculature on day 45 postinoculation.

Overview

Integrity signals

Registry

Crossref · 10.2307/3279659

Cites

16 of 16 references verified0 citation errors · 0 not checkable

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Citations

Cites

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Cited by

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Metadata

Authors
McCracken, R. O.
Corresponding author
McCracken, Richard O.
Venue
The Journal of Parasitology
Publisher
JSTOR
Published
1978-04
Volume
64
Issue
2
Pages
214
ISSN
0022-3395 (ISSN-L)
DOI
10.2307/3279659
OpenAlex
W2318040077
Cited by
42
References
16
Citations by year
2026: 1 · 2024: 3 · 2023: 2 · 2022: 4 · 2021: 3 · 2020: 3 · 2019: 1 · 2015: 1
FWCI
1.10
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Parasitology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Infectious Diseases › Parasitic Diseases Research and Treatment
  • Life Sciences › Immunology and Microbiology › Parasitology › Helminth infection and control
  • Life Sciences › Immunology and Microbiology › Parasitology › Parasites and Host Interactions
Keywords
Trichinella spiralis, mebendazole, albendazole, benzimidazole anthelmintics, drug sensitivity, muscle larvae, trichinellosis
MeSH terms
Administration, Oral, Animals, Benzimidazoles, Male, Mebendazole, Trichinellosis, Mice

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CoChat. (2026). Citation check: Efficacy of Mebendazole and Albendazole against Trichinella spiralis in Mice. https://app.cochat.ai/papers/10.2307/3279659
The paper
McCracken, R. O. (1978). Efficacy of Mebendazole and Albendazole against Trichinella spiralis in Mice. The Journal of Parasitology. https://doi.org/10.2307/3279659

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.