The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
A Quantitative Comparison of Potentially Lethal Damage Repair and the Rejoining of Interphase Chromosome Breaks in Low Passage Normal Human Fibroblasts
Abstract
After long postirradiation incubation periods, the residual frequency of prematurely condensed chromosome fragments following X-ray exposure of noncycling diploid human fibroblasts was found to be correlated with the frequency of chromosome aberrations observed under identical treatment conditions when the cells were subcultured and scored after they reached mitosis. Over a wide range of doses, the proportion of such cells without aberrations at their first metaphase was not significantly different from the proportion able to form macroscopic colonies. Further, the rate of rejoining of interphase chromosome breaks was the same as the rate of increase in survival due to the repair of potentially lethal damage (PLD). These results suggest that there is a one-to-one correspondence between the initial breakage and rejoining of G0 chromosomes and the induction and repair of PLD measured by delayed plating from plateau-phase cultures of these cells.
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Citations
Cites
Repair processes in radiation biology
Elkind, M. M. (1984) · Radiation Research · doi:10.2307/3576409 · Cited by 110
Cited by
The role of DNA double strand breaks in lonizing radiation‐induced killing of eukaryotic cells
Lliakis, G. (1991) · BioEssays · doi:10.1002/bies.950131204 · Cited by 329
Stewart, R. D., Streitmatter, S. W., Argento, D. C., Kirkby, C., Goorley, J. T., Moffitt, G., Jevremovic, T., & Sandison, G. A. (2015) · Physics in Medicine & Biology · doi:10.1088/0031-9155/60/21/8249 · Cited by 103
Carante, M. P., Aimè, C., Cajiao, J. J. T., & Ballarini, F. (2018) · Physics in Medicine & Biology · doi:10.1088/1361-6560/aab45f · Cited by 52
Chromosome aberrations and cell death by ionizing radiation: evolution of a biophysical model
Ballarini, F., & Carante, M. P. (2016) · Radiation Physics and Chemistry · doi:10.1016/j.radphyschem.2016.06.009 · Cited by 45
Ottolenghi, A., Ballarini, F., & Merzagora, M. (1999) · Radiation and Environmental Biophysics · doi:10.1007/s004110050132 · Cited by 36
Metadata
- Authors
- Cornforth, M. N., & Bedford, J. S.
- Venue
- Radiation Research
- Publisher
- JSTOR
- Published
- 1987-09
- Volume
- 111
- Issue
- 3
- Pages
- 385
- ISSN
- 0033-7587 (ISSN-L)
- OpenAlex
- W2140186362
- Cited by
- 332
- References
- 1
- FWCI
- 10.60
- Type
- journal article
- Language
- en
- Open access
- closed
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- Cornforth, M. N., & Bedford, J. S. (1987). A Quantitative Comparison of Potentially Lethal Damage Repair and the Rejoining of Interphase Chromosome Breaks in Low Passage Normal Human Fibroblasts. Radiation Research. https://doi.org/10.2307/3576926
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
