Effect of donor age on function of isolated human islets
Open accessAbstract
This study intended to evaluate the impact of donor age on the function of isolated islets. Analysis of human islets from cadaveric donors (age 16–70 years) was performed using glucose-stimulated insulin release (GSIR) (n = 93), islet ATP content (n = 27), diabetic nude mouse bioassay (n = 72), and the insulin secretory function after single-donor clinical islet allotransplantation (n = 7). The GSIR index was significantly higher in younger donors (age ≤40 years) than in older donors and negatively correlated with the donor age (r = −0.535). Islet ATP was higher in younger donors (115.7 ± 17.7 vs. 75.7 ± 6.6 pmol/μg DNA). The diabetes reversal rate of mice with 2,000 IE was significantly higher in younger donors (96 vs. 68%). C-peptide increment to glucose during intravenous glucose tolerance test at days 90–120 after clinical transplantation showed negative correlation with donor age (r = −0.872) and positive correlation with the islet mass (r = 0.832). On the other hand, acute insulin response to arginine only showed correlation with the islet mass and not with donor age. These results show that insulin secretory response to glucose deteriorates with increasing age and that it may be related to changes in ATP generation in β-cells.
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Islets from young donors have been reported to perform better when transplanted into type 1 diabetic patients.
“Similarly, islets from young donors have been reported to perform better when transplanted into type 1 diabetic patients (32).”
From Adaptive β-Cell Proliferation Is Severely Restricted With Advanced Age (2009) · cites this paper as [32]
Islets from human cadaveric donors are typically in the 4th-6th decade of life and are therefore much more mature.
“Notably, islets from human cadaveric donors are typically in the 4th–6th decade of life and are therefore much more mature (32).”
From Adaptive β-Cell Proliferation Is Severely Restricted With Advanced Age (2009) · cites this paper as [32]
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References 48 · Cited by 130
- Authors
- Ihm, S.-H., Matsumoto, I., Sawada, T., Nakano, M., Zhang, H. J., Ansite, J. D., Sutherland, D. E. R., & Hering, B. J.
- Affiliations
- University of Minnesota (US)
- Venue
- Diabetes
- Publisher
- American Diabetes Association
- Published
- 2006-05-01
- Volume
- 55
- Issue
- 5
- Pages
- 1361-1368
- ISSN
- 0012-1797 (ISSN-L)
- 1939-327X
- OpenAlex
- W2155116317
- Cited by
- 130
- References
- 48
- Citations by year
- 2026: 4 · 2025: 4 · 2024: 7 · 2023: 2 · 2022: 6 · 2021: 10 · 2020: 5 · 2019: 4 · 2018: 12 · 2017: 7 · 2016: 5 · 2015: 1 · 2014: 9 · 2013: 7 · 2012: 6
- FWCI
- 9.52
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Diabetes (publishedVersion)
- PubMed (publishedVersion)
- UCLA - Biblioteca de Ciencias de la Salud (submittedVersion)
- Funders
- University of Minnesota
- National Institutes of Health (5u42rr016598-08)
- National Cancer Institute
- National Center for Research Resources (U42 RR016598-01, M01RR000400, M01-RR00400)
- NIH Clinical Center
- Topics
- Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Diabetes and associated disorders
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
- Keywords
- donor age, islet transplantation, glucose-stimulated insulin secretion, beta-cell function, islet mass, C-peptide, arginine-stimulated insulin secretion, deceased donor
- MeSH terms
- Insulin Secretion, Adenosine Triphosphate, Adolescent, Adult, Age Factors, Aged, Blood Glucose, Cadaver, Cause of Death, Creatinine, Diabetes Mellitus, Type 1, Female, Glucose, Humans, Insulin, Islets of Langerhans, Male, Middle Aged, Tissue Donors, Islets of Langerhans Transplantation
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