The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Association of Transcription Factor 7-Like 2 (TCF7L2) Variants With Type 2 Diabetes in a Finnish Sample
Open accessAbstract
Transcription factor 7-like 2 (TCF7L2) is part of the Wnt signaling pathway. Genetic variants within TCF7L2 on chromosome 10q were recently reported to be associated with type 2 diabetes in Icelandic, Danish, and American (U.S.) samples. We previously observed a modest logarithm of odds score of 0.61 on chromosome 10q, ∼1 Mb from TCF7L2, in the Finland-United States Investigation of NIDDM Genetics study. We tested the five associated TCF7L2 single nucleotide polymorphism (SNP) variants in a Finnish sample of 1,151 type 2 diabetic patients and 953 control subjects. We confirmed the association with the same risk allele (P value <0.05) for all five SNPs. Our strongest results were for rs12255372 (odds ratio [OR] 1.36 [95% CI 1.15–1.61], P = 0.00026) and rs7903146 (1.33 [1.14–1.56], P = 0.00042). Based on the CEU HapMap data, we selected and tested 12 additional SNPs to tag SNPs in linkage disequilibrium with rs12255372. None of these SNPs showed stronger evidence of association than rs12255372 or rs7903146 (OR ≤1.26, P ≥ 0.0054). Our results strengthen the evidence that one or more variants in TCF7L2 are associated with increased risk of type 2 diabetes.
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Citations
Cites
Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes
Grant, S. F. A., Thorleifsson, G., Reynisdottir, I., Benediktsson, R., Manolescu, A., Sainz, J., Helgason, A., Stefansson, H., Emilsson, V., Helgadottir, A., et al. (2006) · Nature Genetics · doi:10.1038/ng1732 · Cited by 2,287
Cited by
A genome-wide association study identifies novel risk loci for type 2 diabetes
Sladek, R., Rocheleau, G., Rung, J., Dina, C., Shen, L., Serre, D., Boutin, P., Vincent, D., Belisle, A., Hadjadj, S., et al. (2007) · Nature · doi:10.1038/nature05616 · Cited by 2,993
Genome-wide association studies in diverse populations
Rosenberg, N. A., Huang, L., Jewett, E. M., Szpiech, Z. A., Jankovic, I., & Boehnke, M. (2010) · Nature Reviews Genetics · doi:10.1038/nrg2760 · Cited by 566
Self-citationAli, O. (2013) · World Journal of Diabetes · doi:10.4239/wjd.v4.i4.114 · Cited by 350
Wnt/β-catenin signaling in adipogenesis and metabolism
Prestwich, T. C., & MacDougald, O. A. (2007) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2007.09.014 · Cited by 355
Schäfer, S. A., Tschritter, O., Machicao, F., Thamer, C., Stefan, N., Gallwitz, B., Holst, J. J., Dekker, J. M., t’Hart, L. M., Nijpels, G., et al. (2007) · Diabetologia · doi:10.1007/s00125-007-0753-6 · Cited by 308
Metadata
- Authors
- Scott, L. J., Bonnycastle, L. L., Willer, C. J., Sprau, A. G., Jackson, A. U., Narisu, N., Duren, W. L., Chines, P. S., Stringham, H. M., Erdos, M. R., Valle, T. T., Tuomilehto, J., Bergman, R. N., Mohlke, K. L., Collins, F. S., & Boehnke, M.
- Venue
- Diabetes
- Publisher
- American Diabetes Association
- Published
- 2006-09-01
- Volume
- 55
- Issue
- 9
- Pages
- 2649-2653
- ISSN
- 0012-1797 (ISSN-L)
- 1939-327X
- OpenAlex
- W2103347314
- Cited by
- 236
- References
- 1
- FWCI
- 19.79
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Scott, L. J., Bonnycastle, L. L., Willer, C. J., Sprau, A. G., Jackson, A. U., Narisu, N., Duren, W. L., Chines, P. S., Stringham, H. M., Erdos, M. R., Valle, T. T., Tuomilehto, J., Bergman, R. N., Mohlke, K. L., Collins, F. S., & Boehnke, M. (2006). Association of Transcription Factor 7-Like 2 (TCF7L2) Variants With Type 2 Diabetes in a Finnish Sample. Diabetes. https://doi.org/10.2337/db06-0341
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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