Enhanced Levels of microRNA-125b in Vascular Smooth Muscle Cells of Diabetic db/db Mice Lead to Increased Inflammatory Gene Expression by Targeting the Histone Methyltransferase Suv39h1

Villeneuve, Louisa M., Kato, Mitsuo, Reddy, Marpadga A., Wang, Mei, Lanting, Linda, Natarajan, Rama·2010·Diabetes

DOI 10.2337/db10-0208

Cited by (186)

Items 101–186 of 186

Micro-RNAs in inflammatory diseases and as a link between inflammation and cancer
Raju Ranjha, J. Paul · 2013 · Inflammation Research
Cholinesterase-Targeting microRNAs Identified in silico Affect Specific Biological Processes
Geula Hanin, Hermona Soreq · 2011 · Frontiers in Molecular Neuroscience
Hepatic miR‐125b inhibits insulin signaling pathway by targeting PIK3CD
Xiliang Du, Xiaobing Li, Liang Chen, Min Zhang, Lin Lei, Wenwen Gao, Zhen Shi, Yuhao Dong, Zhe Wang, Xinwei Li et al. · 2018 · Journal of Cellular Physiology
Cell-specific detection of microRNA expression during cardiomyogenesis by combined in situ hybridization and immunohistochemistry
Mikael Schneider, Ditte Caroline Andersen, Asli Silahtaroglu, Stig Lyngbæk, Sakari Kauppinen, Jakob Lerche Hansen, Søren Paludan Sheikh · 2011 · Journal of Molecular Histology
Long noncoding RNAs C2dat1 enhances vascular smooth muscle cell proliferation and migration by targeting MiR‐34a‐5p
Hairong Wang, Zhili Jin, Pei Tu, Wenhao Song, Yao Gong, Deliang Chen, Lin Zhang, Meichun Zhang, Gangchen Zhang · 2018 · Journal of Cellular Biochemistry
Noncoding RNAs in smooth muscle cell homeostasis: implications in phenotypic switch and vascular disorders
Núria Coll-Bonfill, Benjamin de la Cruz-Thea, María V. Pisano, Melina Mara Musri · 2016 · Pflügers Archiv - European Journal of Physiology
The Impact of Environmental Factors in Influencing Epigenetics Related to Oxidative States in the Cardiovascular System
Francesco Angelini, Francesca Pagano, Antonella Bordin, Marika Milan, Isotta Chimenti, Mariangela Peruzzi, Valentina Valenti, Antonino G. M. Marullo, Leonardo Schirone, Silvia Palmerio et al. · 2017 · Oxidative Medicine and Cellular Longevity
Role of Epigenetic Mechanisms in the Vascular Complications of Diabetes
Marpadga A. Reddy, Rama D Natarajan · 2012 · Sub-cellular biochemistry/Subcellular biochemistry
Functional Long Non-coding RNAs in Vascular Smooth Muscle Cells
Amy Leung, Kenneth Stapleton, Rama D Natarajan · 2015 · Current topics in microbiology and immunology
The inflammatory effect of epigenetic factors and modifications in type 2 diabetes
M Akbari, Vahideh Hassan‐Zadeh · 2019 · Inflammopharmacology
Epigenetic Modifications and Non-Coding RNA in Diabetes-Mellitus-Induced Coronary Artery Disease: Pathophysiological Link and New Therapeutic Frontiers
Francesca Romana Prandi, Dalgisio Lecis, Federica Illuminato, Marialucia Milite, Roberto Celotto, Stamatios Lerakis, Francesco Romeo, Francesco Barillà · 2022 · International Journal of Molecular Sciences
Cellular and Molecular Mechanisms of Diabetic Atherosclerosis: Herbal Medicines as a Potential Therapeutic Approach
Jinfan Tian, Yanfei Liu, Yue Liu, Keji Chen, Shuzheng Lyu · 2017 · Oxidative Medicine and Cellular Longevity
SnoU6 and 5S RNAs are not reliable miRNA reference genes in neuronal differentiation
Lim, Q.E., Zhou, L., Ho, Y.K., Wan, G., Too, H.P. · 2011 · Neuroscience
MicroRNAs: Important Modulators of oxLDL-Mediated Signaling in Atherosclerosis
Erli Zhang, Yongjian Wu · 2012 · Journal of Atherosclerosis and Thrombosis
Circulating miRNAs as Intercellular Messengers, Potential Biomarkers and Therapeutic Targets for Type 2 Diabetes
Paola Mirra, Gregory Alexander Raciti, Cecilia Nigro, Francesca Fiory, Vittoria D’Esposito, Pietro Formisano, Francesco Bèguinot, Claudia Miele · 2015 · Epigenomics
Inflammation o'clock: interactions of circadian rhythms with inflammation‐induced skeletal muscle atrophy
Francielly Morena da Silva, Karyn Ann Esser, Kevin A. Murach, Nicholas Perry Greene · 2023 · The Journal of Physiology
Clinical significance and expression of microRNA in diabetic patients with erectile dysfunction
XI JIANG, YONG LUO, Shuli Zhao, Qichao Chen, Chao Jiang, Yutian Dai, YUN CHEN, Zhigang Cao · 2015 · Experimental and Therapeutic Medicine
MiR-135a Promotes Inflammatory Responses of Vascular Smooth Muscle Cells From db/db Mice via Downregulation of FOXO1
Xiaochun Lu, Dawei Yin, Bo Zhou, Tieling Li · 2018 · International Heart Journal
Epigenetic Histone Modifications in the Pathogenesis of Diabetic Kidney Disease
Hengcheng Lu, Wenni Dai, Liyu He · 2021 · Diabetes Metabolic Syndrome and Obesity
Epigenetics: key to improve delayed wound healing in type 2 diabetes
Rupal Dubey, Pranav Kumar Prabhakar, Jeena Gupta · 2021 · Molecular and Cellular Biochemistry
Increase in hippocampal histone H3K9me3 is negatively correlated with memory in old male mice
Akanksha Kushwaha, Mahendra Kumar Thakur · 2019 · Biogerontology
Epigenetic memory contributing to the pathogenesis of AKI-to-CKD transition
Fumiaki Tanemoto, Masaomi Nangaku, Imari Mimura · 2022 · Frontiers in Molecular Biosciences
Role of Biomarkers in Predicting Diabetes Complications With Special Reference to Diabetic Foot Ulcers
Sivakamasundari Pichu, Bhoomika M. Patel, Subbu Apparsundaram, Ramesh Kishorilal Goyal · 2017 · Biomarkers in Medicine
Metabolic memory: mechanisms and implications for diabetic vasculopathies
Erli Zhang, Yongjian Wu · 2014 · Science China Life Sciences
Molecular Changes in Diabetic Wound Healing following Administration of Vitamin D and Ginger Supplements: Biochemical and Molecular Experimental Study
Hadeel A. Al‐Rawaf, Sami A. Gabr, Ahmad H. Alghadir · 2019 · Evidence-based Complementary and Alternative Medicine · Retracted
Downregulation of microRNA-34b is responsible for the elevation of blood pressure in spontaneously hypertensive rats
Fan Yang, Haiyu Li, Youyou Du, Qiangwei Shi, Luosha Zhao · 2017 · Molecular Medicine Reports
Histone methyltransferase Suv39h1 attenuates high glucose-induced fibronectin and p21WAF1 in mesangial cells
Sheng-Hsuan Lin, Wan-Ting Ho, Yeng‐Tseng Wang, Chao‐Tang Chuang, Lea‐Yea Chuang, Jinn‐Yuh Guh · 2016 · The International Journal of Biochemistry & Cell Biology
miR-125-chinmo pathway regulates dietary restriction-dependent enhancement of lifespan in Drosophila
Manish Pandey, Sakshi Bansal, Sudipta Bar, Amit Kumar Yadav, Nicholas S. Sokol, Jason M. Tennessen, Pankaj Kapahi, Geetanjali Chawla · 2021 · eLife
Long‐lasting partnership between insulin resistance and endothelial dysfunction: role of metabolic memory
Divya Sri Priyanka Tallapragada, Pinakin Arun Karpe, Kulbhushan Tikoo · 2015 · British Journal of Pharmacology
MicroRNAs Overexpressed in Growth-Restricted Rat Skeletal Muscles Regulate the Glucose Transport in Cell Culture Targeting Central TGF-β Factor SMAD4
Santanu Raychaudhuri · 2012 · PLoS ONE
Emerging Roles for MicroRNAs in Diabetic Microvascular Disease: Novel Targets for Therapy
Yu Zhang, Xinghui Sun, Basak Icli, Mark W. Feinberg · 2017 · Endocrine Reviews
Suv39h1 downregulation inhibits neointimal hyperplasia after vascular injury
Jing Zhang, Jing Chen, Jun Yang, Changwu Xu, Qi Zhou Hu, Hui Ming Wu, Wanyin Cai, Qing Guo, Wenqi Gao, Chao He et al. · 2019 · Atherosclerosis
Non-coding RNAs as Epigenetic Gene Regulators in Cardiovascular Diseases
Wanlin Jiang, Devendra K. Agrawal, Chandra Shekhar Boosani · 2020 · Advances in experimental medicine and biology
Down-regulation of SETD6 protects podocyte against high glucose and palmitic acid-induced apoptosis, and mitochondrial dysfunction via activating Nrf2-Keap1 signaling pathway in diabetic nephropathy
Xiang Wang, Qiling Liu, Deqin Kong, Zi Long, YuFang Guo, Shuang Wang, Rui Liu, Chunxu Hai · 2020 · Journal of Molecular Histology
Mechanistic insights into glucose induced vascular epigenetic reprogramming in type 2 diabetes
Priyal Dhawan, Sampara Vasishta, Aswath Balakrishnan, Manjunath Bandu Joshi · 2022 · Life Sciences
Review of the molecular mechanisms in wound healing: new therapeutic targets?
Beniamino Palmieri, Maria Vadalà, Carmen Laurino · 2017 · Journal of Wound Care
Basics of Epigenetics and Role of Epigenetics in Diabetic Complications
Andamuthu Yamunadevi, Ramani Pratibha, Muthusamy Rajmohan, Sengottaiyan Mahendraperumal, Nalliappan Ganapathy · 2021 · Journal of Pharmacy And Bioallied Sciences
Exploratory study on association of genetic variation in TBC1D1 with antipsychotic‐induced weight gain
Eva J. Brandl, Arun Kumar Tiwari, Tristram A. P. Lett, Sajid Ali Shaikh, Jeffrey Alan Lieberman, Herbert Y. Meltzer, James L. Kennedy, Daniel J. Müller · 2013 · Human Psychopharmacology Clinical and Experimental
Inflammation related miRNAs as an important player between obesity and cancers
Morteza Gholami, Bagher A. Larijani, Zhila Zahedi, Fatemeh Mahmoudian, Samira Bahrami, Sima Parvizi Omran, Zahra Saadatian, Shirin Hasani‐Ranjbar, Reza Taslimi, Milad Bastami et al. · 2019 · Journal of Diabetes & Metabolic Disorders
Metabolic stress in the myocardium: Adaptations of gene expression
Peter A. Crawford, Jean E. Schaffer · 2012 · Journal of Molecular and Cellular Cardiology
MicroRNA and Vascular Smooth Muscle Cells
Changqing Xie, Jifeng Zhang, Y. Eugene Chen · 2011 · Vitamins and hormones
Exercise Reduces H3K9me3 and Regulates Brain Derived Neurotrophic Factor and GABRA2 in an Age Dependent Manner
Andra Ionescu-Tucker, Christopher Butler, Nicole C. Berchtold, Dina P. Matheos, Marcelo A. Wood, Carl W. Cotman · 2021 · Frontiers in Aging Neuroscience
“H” for Heterogeneity in the Algorithm for Type 2 Diabetes Management
Silvia Pieralice, Simona Zampetti, Ernesto Maddaloni, Raffaella Buzzetti · 2020 · Current Diabetes Reports
The epigenetic regulation of podocyte function in diabetes
Syamantak Majumder, Andrew Advani · 2015 · Journal of Diabetes and its Complications
Epigenetic modifications and diabetic nephropathy
Marpadga A. Reddy, Jung Tak Park, Rama D Natarajan · 2012 · Kidney Research and Clinical Practice
SUV39H1 Regulates KLF4 and Chromatin Remodeling in Smooth Muscle Cell Phenotypic Plasticity
Payel Chatterjee, Raja Chakraborty, Ashley J. Sizer, Brendan O'Brien, Peng Xu, Jonathan M. Hwa, Yi Xie, Qin Yan, John Hwa, Kathleen A. Martin · 2025 · Arteriosclerosis Thrombosis and Vascular Biology
Oncogene and Non-Oncogene Addiction in Inflammation-Associated Cancers
Min Hua Zheng, Jian Jiang, Ya‐ling Tang, Xin‐hua Liang · 2013 · Future Oncology
Targeting epigenetic regulators for treating diabetic nephropathy
Kriti Kushwaha, Sourbh Suren Garg, Jeena Gupta · 2022 · Biochimie
Suv39h1 Regulates Phenotypic Modulation of Smooth Muscle Cells and Contributes to Vascular Injury by Repressing HIC1 Transcription
Yuyu Yang, Qiumei Zhang, Shuai Liu, Haihang Yuan, Xiaoping Wu, Yi Zou, Yuanyuan Zhang, Junli Guo · 2025 · Arteriosclerosis Thrombosis and Vascular Biology
Epigenetic Contribution to the Development and Progression of Vascular Diabetic Complications
Hanah Rodriguez, Assam El‐Osta · 2018 · Antioxidants and Redox Signaling
Epigenetics: an Expanding New Piece of the Stroke Puzzle
William J. Pearce · 2011 · Translational Stroke Research
Modulation of microRNA 21, 125 b and 451 expression by quercetin intake and exercise in mice fed atherogenic diet
Mahdi Garelnabi, Halleh Mahini · 2014 · Biomedicine & Preventive Nutrition
Differential Response to High Glucose in Skin Fibroblasts of Monozygotic Twins Discordant for Type 1 Diabetes
Maria Luiza Caramori, Youngki Kim, Rama D Natarajan, Jason H. Moore, Stephen S. Rich, Josyf C. Mychaleckyj, Ryoko Kuriyama, David T. Kirkpatrick, Michael S. Mauer · 2015 · The Journal of Clinical Endocrinology & Metabolism
Vascular Smooth Muscle as a Target for Novel Therapeutics
Karen E. Porter, Kirsten Riches‐Suman · 2015 · Current Diabetes Reports
Vascular Remodeling in Diabetes Mellitus
Srikanth Vallurupalli, Jawahar L. Mehta · 2017 · Springer eBooks
Cardiovascular Risk Factors and Markers
Marc Thiriet · 2018 · Biomathematical and biomechanical modeling of the circulatory and ventilatory systems
Down regulation of Jag-1 in VSMCs contributes to impaired angiogenesis under high glucose condition: Experimental study using aortic rings of rats
Seahyoung Lee, Long Hao Yu, La-Ri Lim, Hee-Jung Lim, Jung-Eun Si, Young‐Guk Ko, Ki‐Chul Hwang · 2016 · Clinical Hemorheology and Microcirculation
Relation between anti-atherosclerotic effects of IRAK4 and modulation of vascular smooth muscle cell phenotype in diabetic rats.
Lijuan Cao, Defeng Pan, Dongye Li, Yanbin Zhang, Qiuping Chen, Tongda Xu, Wenhua Li, Wanling Wu · 2016 · PubMed Central
MicroRNAs and Endothelial Dysfunction in Relation to Obesity and Type 2 Diabetes
Dwi Setyowati Karolina · 2014 · Journal of Molecular and Genetic Medicine
Epigenetic Mechanisms of Endothelial Progenitor Cell Dysfunction
Alexander Е. Berezin · 2016 · Journal of Clinical Epigenetics
Demethylation of miR-299-5p by aerobic exercise relieves insulin resistance in the vascular endothelium by repressing resistin.
Ying Cai, Mingzhu Wang, Yujiao Zong, Cui Li, Siqian Fu, Kang-Ling Xie · 2022 · Diabetes Research and Clinical Practice
miRNA Biology in Pathological Processes
Xueji Zhang, Haifeng Dong, Yaping Tian · 2015 · Springer briefs in molecular science
Inhibiting BDNF Signaling Upregulates Hippocampal H3K9me3 in a Manner Dependent On In Vitro Aging and Oxidative Stress
Andra Ionescu-Tucker, Liqi Tong, Nicole C. Berchtold, Carl W. Cotman · 2022 · Frontiers in Aging
RETRACTED ARTICLE: Overexpression of circARF3 mitigates TNF-α-induced inflammatory damage by up-regulating miR-125b
Yingying Zhang, Binghui Hou, Chunxiao Li, Hong Li · 2020 · Cell Cycle · Retracted
Obesity and Systemic Inflammation: Insights into Epigenetic Mechanisms
Perla Kaliman, Marcelina Párrizas · 2011 · InTech eBooks
Targeting the NAD + -SIRT3 axis to mitigate metabolic memory in diabetic kidney disease
Yufei Zhang, Yudian Wang, Yuhang Qiao, L S Liu, Hailing Zhao, Qi Jin, Liang Peng, Ping Li · 2026 · Renal Failure
From Cradle to the Grave: Tissue-specific microRNA signatures in detecting clinical progression of diabetes
Ryan J. Farr, Caroline J. Taylor, Sarang N. Satoor, Michael D. Williams, Mugdha V. Joglekar · 2013 · Non-coding RNAs in Endocrinology
Role of microRNAs in aquaporin 2 regulation
Federica Petrillo, Francesco Trepiccione · 2022 · Current Opinion in Nephrology & Hypertension
Non-coding RNAs Related to Atherosclerosis
Paul Holvoet · 2021 · Springer eBooks
SUV39H1 mediated regulation of KLF4 and KDM4A coordinate smooth muscle cell phenotypic plasticity
Payel Chatterjee, Raja Chakraborty, Ashley J. Sizer, Brendan J. O’Brien, Yi Xie, John Hwa, Kathleen A. Martin · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
Effects of inflammation on hypoxic renal tubular epithelial cell injury under high-glucose conditions and the regulatory role of miR-125b
Xin Shen, Yang Liu, Jiahui Zhao, Qingli Cheng, Guang Yang · 2025 · Scientific Reports
Hyperglycemia, Oxidative Stress, and Vascular Complications: Role of Epigenetic Mechanisms
Estelle R. Simo‐Cheyou, Ashok K. Srivastava · 2013 · Springer eBooks
CHROMO domain readers: A rainbow of opportunities
Xueqin Sherine Sun, Padmina Shrestha, Alea A. Mills · 2023 · Elsevier eBooks
Role of Non-coding RNAs in Vascular Complications of Diabetes Mellitus
Sumi Surendran, C. Sudha Kartha · 2017 · Springer eBooks
Epigenetic Basis of Oxidative Stress in Diabetic Coronary Atherosclerosis: A Shift in Focus from Genetic Prerogative
Parimala Narne · 2019 · Springer eBooks
MicroRNAs and Endothelial Dysfunction in Relation to Obesity and Type
Silambarasan Maskomani, Arunmozhiarasi Armugam, Kandiah Jeyaseelan · 2014
Diabetic nephropathy—emerging epigenetic
Rama D Natarajan · 2014
Tissue-specific 3 prime-end adenylation of miR-125b mediates cell survival
Matthew T. Blahna, Jean-Charles Neel, Ge Yu, Justin Louie, Prajakta Ghatpande, Giorgio Lagna, Akiko Hata · 2019 · bioRxiv (Cold Spring Harbor Laboratory)
Epigenetic mechanisms in cardiovascular diseases
Sudhahar Varadarajan, Masuko Ushio‐Fukai, Tohru Fukai · 2023 · Elsevier eBooks
MicroRNA modulation in metabolic syndrome: A novel insight into cardiometabolic diseases
Sandeep Kumar, Li Li, Sudhiranjan Gupta · 2024 · Elsevier eBooks
In vivo inhibition of miR-125b modulates monocyte trafficking through the CCR7 receptor and attenuates atherosclerosis
Adrián Mallén, Cristian Varela, Noemí Rotllán, Valentina Paloschi, Lars Mäegdefessel, Joan Carles Escolá‐Gil, Josep Maria Aran, Estanis Navarro, Miguel Hueso · 2024 · medRxiv
Mémoire épigénétique des trajectoires pondérales maternelles préconceptionnelles au cours du développement et à long terme
Polina E. Panchenko · 2015 · theses.fr (ABES)
Role of thrombopoietin in DNA repair an genomic integrity in hematopoietic stem cells
Daniela Barbieri · 2017 · theses.fr (ABES)
Cardiovascular Dysfunction in Type 2 Diabetes: The Role of MicroRNAs
Gizem Kayki‐Mutlu, Ebru Arioglu-Inan · 2026 · Handbook of experimental pharmacology
Epigenetics and metabolic memory
Jeena Gupta · 2026 · Elsevier eBooks
Histone post-translational modifications in diabetic foot ulcer healing: linking immune dysregulation to tissue repair
Jing-Bo Hou, Jun-Zhe Chen, Yue-Zhong Chen, Zi-Yi Luo, Shao-Xiang Yuan, Cheng-Liang Deng, Shu-Ne Xiao · 2026 · Frontiers in Immunology