LECT2 functions as a hepatokine that links obesity to skeletal muscle insulin resistance

Lan, Fei, Misu, Hirofumi, Chikamoto, Keita, Takayama, Hiroaki, Kikuchi, Akihiro, Mohri, Kensuke, Takata, Noboru, Hayashi, Hiroto +18 more·2014·Diabetes

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Items 101–158 of 158

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  2. Circulating Concentrations of Insulin Resistance-Associated Hepatokines, Selenoprotein P and Leukocyte Cell-Derived Chemotaxin 2, during an Oral Glucose Tolerance Test in Humans
    Kensuke Mohri, Hirofumi Misu, Hiroaki Takayama, Kiyo‐aki Ishii, Akihiro Kikuchi, Fei Lan, Yasufumi Enyama, Yumie Takeshita, Yoshiro Saito, Shuichi Kaneko et al. · 2018 · Biological and Pharmaceutical Bulletin
  3. Effect of a LECT2 on the immune response of peritoneal lecukocytes against Vibrio anguillarum in roughskin sculpin
    Yingmei Chai, Bailin Cong, Shanshan Yu, Yingying Liu, Xin Man, Lujie Wang, Qian Zhu · 2018 · Fish & Shellfish Immunology
  4. Renal amyloidogenic leukocyte chemotactic factor 2 combined with IgA nephropathy: A case report
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  5. Leukocyte cell-derived chemotaxin-2 and fibroblast growth factor 21 in alcohol-induced liver cirrhosis
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  6. LECT2 modulates dendritic cell function after Helicobacter pylori infection via the CD209a receptor
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  7. Hepatokines and Adipokines in Metabolic Syndrome
    Alpana Mukhuty, Samim Ali Mondal, Satinath Mukhopadhyay · 2023 · Annals of the National Academy of Medical Sciences (India)
  8. Leukocyte cell‐derived chemotaxin 2 correlates with pediatric non‐alcoholic fatty liver disease
    Diego Paine‐Cabrera, Lisa K. Harvey, Dakota R. Robarts, Michele T. Pritchard, John P. Thyfault, Steven A. Weinman, Udayan M. Apte, Voytek Slowik · 2023 · Clinical and Translational Science
  9. Relationship between the changes in hepatokine levels and metabolic effects after laparoscopic sleeve gastrectomy in severely obese patients
    Akira Umemura, Akira Sasaki, Toshinari Takamura, Hiroaki Takayama, Yumie Takeshita, Yosuke Toya, Keisuke Kakisaka, Yutaka Hasegawa, Yasushi Ishigaki · 2023 · Surgery Today
  10. Plasma half-life and tissue distribution of leukocyte cell-derived chemotaxin 2 in mice
    Akihiro Kikuchi, Hiroaki Takayama, Hirohiko Tsugane, Kazuhiro Shiba, Keita Chikamoto, Tatsuya Yamamoto, Seiichi Matsugo, Kiyo‐aki Ishii, Hirofumi Misu, Toshinari Takamura · 2020 · Scientific Reports
  11. Metabolic Dysfunction-Associated Steatotic Liver Disease and Sarcopenia: Review of Literature
    Hiroki Nishikawa, Soo Ki Kim, Sachiyo Yoshio, AKIRA ASAI · 2026 · Journal of Clinical Medicine
  12. Hepatokine leukocyte cell‐derived chemotaxin 2 as a biomarker of insulin resistance, liver enzymes, and metabolic dysfunction‐associated steatotic liver disease in the general population
    Keita Suzuki, Hiromasa Tsujiguchi, Akinori Hara, Yumie Takeshita, Hisanori Goto, Yujiro Nakano, Reina Yamamoto, Hiroaki Takayama, Atsushi Tajima, Tatsuya Yamashita et al. · 2024 · Journal of Diabetes Investigation
  13. Elevated serum levels of leukocyte cell-derived chemotaxin 2 are associated with the prevalence of metabolic syndrome
    Xialei Zheng, Junmi Lu, Shaojun Xiang, Pu Zou, Hao Chen, Jing Liu, Cheng Chu Zeng, Yuhu He · 2024 · Acta Diabetologica
  14. LECT 2 Antagonizes FOXM1 Signaling via Inhibiting MET to Retard PDAC Progression
    Xin Li, Pingping Lin, Ye Tao, Xin Jiang, Ting Li, Yunshan Wang, Chenjing Wang, Yu J Cao · 2021 · Frontiers in Cell and Developmental Biology
  15. Luseogliflozin and caloric intake restriction increase superoxide dismutase 2 expression, promote antioxidative effects, and attenuate aortic endothelial dysfunction in diet‐induced obese mice
    Shigeru Kawade, Kazuma Ogiso, Sigfrid Casmir Shayo, Takahiko Obo, Aiko Arimura, Hiroshi Hashiguchi, Takahisa Deguchi, Yoshihiko Nishio · 2023 · Journal of Diabetes Investigation
  16. Hepatic miR‑215 target Rictor and modulation of hepatic insulin signalling in rats
    Weidong Li, Xia Jin-rong, Yan‐Shu Lian · 2019 · Molecular Medicine Reports
  17. Discovery of novel obesity genes through cross-ancestry analysis
    Deepro Banerjee, Santhosh Girirajan · 2024 · medRxiv
  18. Differentially expressed genes in cotyledon of ewes fed mycotoxins
    Jessica L. Britt, Rooksana E. Noorai, S. K. Duckett · 2020 · BMC Genomics
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  20. Global research trends and hotspots for leukocyte cell-derived chemotaxin-2 from the past to 2023: a combined bibliometric review
    Wei Liu, Qin Wang, Jianishaya Yeerlan, Yirui Yan, Luke Xu, Cui Jia, Xinlian Liu, Lushun Zhang · 2024 · Frontiers in Immunology
  21. Green tea extracts reduce leukocyte cell–Derived chemotaxin 2 and selenoprotein P levels in the livers of C57BL/6J mice fed a high-fat diet
    Shintaro Onishi, Hidefumi Kitazawa, Shinichi Meguro, Ichiro Tokimitsu · 2018 · Bioscience Biotechnology and Biochemistry
  22. Iron overload in steatotic hepatocytes drives systemic metabolic dysfunction via alterations in hepatokine production
    Hye Jin Jo, Ayoung Kim, Hyunsoo Rho, Ae Kyung Park, Gil-Hwan Kim, Seo Jeong Jo, Hao Yuxin, You-Jung Hong, Ji Min Yeon, Hwang Chan Yu et al. · 2026 · Journal of Clinical Investigation
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  24. Effect of Intracerebroventricular Administration of Galanin-Like Peptide on Hepatokines in C57BL/6 J Mice
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  25. Plasma Leukocyte Cell-Derived Chemotaxin-2 as a Risk Factor of Sarcopenia: Korean Frailty and Aging Cohort Study
    Eun Roh, Soon Young Hwang, Miji Kim, Chang Won Won, Kyung Mook Choi · 2025 · Nutrients
  26. Protein misfolding, aggregation and other factors determining the amyloidogenic landscape of human leucocyte chemotaxin-2: A review
    Akhilesh Kumar, Sudarshan Singh Lakhawat, Naveen Kumar Malik, Vinay Sharma, Yashdeep Singh, Ananya Jain, Vinod Sharma, Sandeep Kumar Singh, Pushpender Kumar Sharma · 2025 · Archives of Biochemistry and Biophysics
  27. Associations of Leukocyte-Derived Chemotaxin-2 (LECT2) with Insulin Resistance and Metabolic Syndrome in Type 2 Diabetes: A Cross-Sectional Study
    Yujing Sha, Jiaping Lu, Rui Jin, Lian Li, Min Zhang · 2025 · Diabetes Metabolic Syndrome and Obesity
  28. Elevated LECT2 and PEDF in Pediatric MAFLD: Diagnostic Performance and Metabolic Correlations
    Lanshu Yang, Hongbing Ni, Meiling Deng, Tuo Guo, Jie Zhang, Baolan Sun, Weixia Yang · 2025 · Diabetes Metabolic Syndrome and Obesity
  29. Lean metabolic dysfunction-associated steatotic liver disease: Current insights and knowledge gaps
    Praveen Sandeep Raj R., Rebecca John, Felix Manoharan, Asisha M. Janeela, Ashish Goel, Nitin Kapoor · 2026 · Best Practice & Research Clinical Endocrinology & Metabolism
  30. Circulating leukocyte cell-derived chemotaxin 2 and fibroblast growth factor 21 are negatively associated with cardiorespiratory fitness in healthy volunteers
    Sundus Malaikah, Scott A. Willis, Joseph J. Henson, Jack Alistair Sargeant, Thomas E. Yates, Alice Emily Thackray, Fernanda Reistenbach Goltz, Matthew J Roberts, Danielle Bernard-Deshong, Guruprasad Padur Aithal et al. · 2023 · Applied Physiology, Nutrition, and Metabolism
  31. From Liver to Muscle: Crosstalk Mechanisms and Interventions in Sarcopenia
    Qiquan Wang, Yao Meng, Xiang Wang, Xinqiang Lan, Guoxin Fan, Yang Xiang · 2025 · Health and Metabolism
  32. Micro RNAs as Biomarkers of Bariatric Surgery Outcome and Putative Regulators of Hepatokines Selectively after Gastric Bypass, but not Sleeve Gastrectomy
    Aida Zarfeshani · 2016 · Journal of Obesity and Bariatrics
  33. Will inhibition of cellular crosstalk resolve liver fibrosis?
    Edward N. Harris · 2022 · Hepatology
  34. Stéatose et résistance à l’insuline : implication des hépatokines
    Chantal Bertrand, Philippe Valet, Isabelle Castan‐Laurell · 2015 · Obésité
  35. Ectopic Fat Accumulation in the Liver and Glucose Homeostasis
    Toshinari Takamura, Hirofumi Misu, Shuichi Kaneko · 2016 · Springer eBooks
  36. III. Relation with Type II Diabetes: Regulation by Hepatokines
    Hirofumi Misu · 2016 · Nihon Naika Gakkai Zasshi
  37. Adipose tissue metabolism and cardiometabolic health in obesity
    Stinkens · 2017
  38. Early Hepatic Signals of Fat Overload
    Javier Thomas Gonzalez · 2020 · Journal of Nutrition
  39. Rôle des hépatokines dans le dialogue inter-organes en physiologie et physiopathologie
    Aude Pacheco, Catherine Postic · 2020 · Médecine des Maladies Métaboliques
  40. Hepatokine ERAP1 impairs skeletal muscle insulin sensitivity via ADRB2/PKA pathway
    Feifan Guo, Yuguo Niu, Haizhou Jiang, Hanrui Yin, Fenfen Wang, Xiaoming Hu, Shanghai Chen · 2020 · Research Square
  41. An amyloidosis-associated polymorphism does not alter LECT2 stability in vitro
    Liudmila Belonogov, Paris E. Taylor, Sherry Wong, Gareth J. Morgan · 2022 · bioRxiv (Cold Spring Harbor Laboratory)
  42. Markers of Liver Function and Insulin Resistance
    Vicente Aleixandre Benites-Zapata, Sofía Lorena Bohórquez-Medina, Andrea Lisbet Bohórquez-Medina · 2022 · Biomarkers in disease
  43. Hepatokine
    H. Fiedler · 2019 · Springer Reference Medizin
  44. Hepatokine
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  45. Markers of Liver Function and Insulin Resistance
    Vicente Aleixandre Benites-Zapata, Sofía Lorena Bohórquez-Medina, Andrea Lisbet Bohórquez-Medina · 2022 · Biomarkers in disease
  46. Transcriptome analysis revealed the existence of family-specific regulation of growth traits in grass carp
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  47. Renal Amyloidogenic Leukocyte Chemotactic Factor 2 Combined with Immunoglobulin A Nephropathy: 2 Case Reports and literature review
    Li Dan Zhao, Yanan Li, Ruihua Shen, Dan Niu, Wei xia Han, Chen Wang, Shulei Yao, Xiao hua Zhang, Lingyun Zhang, Lihua Wang et al. · 2024 · Research Square
  48. The Hepatokine Leukocyte Cell-Derived Chemotaxin-2 Is Elevated in People with Impaired Glycaemic Regulation and Augmented by Acute Exercise
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  53. Rôle de LECT2 dans les maladies stéatosiques non alcooliques du foie
    Sandrine Pham · 2020 · theses.fr (ABES)
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  55. LS21013A-06, a PDE4 inhibitor, preserves blood-brain barrier integrity in experimental ischemic stroke models through PKA-dependent modulation of LECT2
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  56. Cryo-EM structures of ALECT2 filaments from human renal biopsies
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  57. Hepatic Senp2 deletion resolves the angiogenic switch in fibrosis via β-catenin/LECT2.
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