A Regulatory T-Cell Gene Signature Is a Specific and Sensitive Biomarker to Identify Children With New-Onset Type 1 Diabetes

Pesenacker, Anne M.; Wang, Adele Y.; Singh, Amrit; Gillies, Jana; Kim, Youngwoong; Piccirillo, Ciriaco A.; Nguyen, Duc; Haining, W. Nicholas; Tebbutt, Scott J.; Panagiotopoulos, Constadina; Levings, Megan K.

doi:10.2337/db15-0572

A Regulatory T-Cell Gene Signature Is a Specific and Sensitive Biomarker to Identify Children With New-Onset Type 1 Diabetes

Type 1 diabetes (T1D) is caused by immune-mediated destruction of insulin-producing β-cells. Insufficient control of autoreactive T cells by regulatory T cells (Tregs) is believed to contribute to disease pathogenesis, but changes in Treg function are difficult to quantify because of the lack of …