Inhibiting microglia expansion prevents diet-induced hypothalamic and peripheral inflammation

André, Caroline, Guzman-Quevedo, Omar, Rey, Charlotte, Rémus-Borel, Julie, Clark, Samantha, Castellanos-Jankiewicz, Ashley, Ladeveze, Elodie, Leste-Lasserre, Thierry +4 more·2017·Diabetes

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Items 101–184 of 184

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  4. Extracellular vesicles released from microglia after palmitate exposure impact brain function
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  5. mTORC1 pathway disruption abrogates the effects of the ciliary neurotrophic factor on energy balance and hypothalamic neuroinflammation.
    C. André, C. Catania, Julie Rémus-Borel, E. Ladevèze, T. Leste-Lasserre, W. Mazier, E. Binder, Delphine Gonzales, Samantha Clark, O. Guzmán-Quevedo et al. · 2018 · Brain, behavior, and immunity
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  7. Microgliosis: a double‐edged sword in the control of food intake
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  11. Impaired Hypothalamic Microglial Activation in Offspring of Antibiotic-Treated Pregnant/Lactating Rats Is Attenuated by Prebiotic Oligofructose Co-Administration
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  15. Overview of peripheral and central inflammatory responses and their contribution to neurotoxicity
    Nikolay M. Filipov · 2018 · Advances in neurotoxicology
  16. CD1 is involved in diet-induced hypothalamic inflammation in obesity
    Bruna Bombassaro, Albina F. S. Ramalho, Milena Fioravante, Carina Solon, Guilherme Augusto Silva Nogueira, Pedro A. S. Nogueira, Rodrigo S. Gaspar, Eduardo Rochete Ropelle, Licio Augusto Velloso · 2019 · Brain Behavior and Immunity
  17. Sex-specific effects of ketogenic diet after pre-exposure to a high-fat, high-sugar diet in rats
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  18. Deletion of the Alzheimer’s disease risk gene Abi3 locus results in obesity and systemic metabolic disruption in mice
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  19. Redefining the timeline: a three-phase framework of hypothalamic microinflammation in metabolic disease
    Sebastián Zagmutt, María Rodriguez-Garcia, Montserrat Bolaños-Hurtado, Ana Cristina Reguera, Núria Casals, Rosalía Rodríguez‐Rodríguez · 2025 · Reviews in Endocrine and Metabolic Disorders
  20. Effects and mechanism of berberine in ameliorating microglia-mediated hypothalamic inflammation by downregulating the MAPK and NF-κB pathway
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  21. Hypothalamic neuroinflammation induced by obesity and the effect of Liraglutide
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  22. Does elevated bilirubin aid weight control by preventing development of hypothalamic leptin resistance?
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  23. Microglia/macrophage-specific deletion of TLR-4 protects against neural effects of diet-induced obesity in a sexually dimorphic manner
    Jiahui Liu, Ali Hussainy Zaidi, Christian J. Pike · 2025 · Journal of Neuroinflammation
  24. Exercise training improves long-term memory in obese mice
    Oliver K Fuller, Casey L. Egan, Tina L Robinson, Nimna Perera, Heidy K. Latchman, Lauren V. Terry, Emma D. McLennan, Carolina A. Chavez, Emma L. Burrows, John W. Scott et al. · 2023 · Life Metabolism
  25. Molecular mechanisms and the vital roles of resistin, TLR 4, and NF-κB in treating type 2 diabetic complications
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  27. High-fat diet exacerbates cognitive and metabolic abnormalities in neuronal BACE1 knock-in mice – partial prevention by Fenretinide
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  28. Addition of Opuntia ficus-indica Reduces Hypothalamic Microglial Activation and Improves Metabolic Alterations in Obese Mice Exposed to a High-fat Diet
    Mercedes Victoria Urquiza-Martínez, Héctor Eduardo Martínez‐Flores, Omar Guzmán‐Quevedo, Ana Elisa Toscano, Raul Manhães‐de‐Castro, Luz Torner, Rosalío Mercado-Camargo, Rosa Elena Pérez-Sánchez, María Carmen Bartolomé‐Camacho · 2020 · Journal of Food and Nutrition Research
  29. Tanycytes in the nexus of hypothalamic inflammation, appetite control, and obesity
    Rafik Dali, Fanny Langlet · 2025 · Physiology & Behavior
  30. Dual functions of CNS inflammation in food intake and metabolic regulation
    Tien-Jui Lee, Sara L. Hargrave, Kimberly P. Kinzig · 2020 · Brain Research
  31. Brain Inflammation and Endoplasmic Reticulum Stress
    I. Çakır, E. Nillni · 2018 · Springer eBooks
  32. Effects of Intranasally Administered Insulin and Gangliosides on Metabolic Parameters and Activity of the Hepatic Insulin System in Rats with Type 2 Diabetes Mellitus
    Irina O. Zakharova, Liubov V. Bayunova, Kira Viktorovna Derkach, I. O. Ilyasov, Alexander Olegovich Shpakov, Natalia F. Avrova · 2022 · Journal of Evolutionary Biochemistry and Physiology
  33. Microglia/macrophage-specific deletion of TLR-4 protects against neural effects of diet-induced obesity
    Jiahui Liu, Ali Hussainy Zaidi, Christian J. Pike · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
  34. Oral cytarabine ocfosfate pharmacokinetics and assessment of leukocyte biomarkers in normal dogs
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  35. Intermittent Overconsumption of High Fat Diet Promotes Microglial Reactivity in the Hypothalamus and Hindbrain of Female Rats
    Alexis A. Campanile, Lisa A. Eckel · 2025 · Cells
  36. Sufficient Cav-1 levels in the endothelium are critical for the maintenance of the neurovascular unit in the retina
    Yixin Wang, Mahmoud Halawa, Anupriya Chatterjee, Rachana Eshwaran, Yi Hua Qiu, Yohanes Cakrapradipta Wibowo, Jianyuan Pan, Thomas Wieland, Yuxi Feng · 2023 · Molecular Medicine
  37. A high-fat diet influences neural stem and progenitor cell environment in the medulla of adult mice
    Eriko Furube, Masahiro Ohgidani, Yusuke Tanaka, Seiji Miyata, Shigetaka Yoshida · 2024 · Neuroscience
  38. Fat food exacerbates post-prandial hypothalamic inflammation involving GFAP+ cells and microglia
    Céline Cansell, Katharina Stobbe, Ophélia Le Thuc, CA. Mosser, Selma Ben Fradj, Joris Leredde, Cynthia Lebeaupin, Delphine Debayle, Lucile Fleuriot, Frédéric Brau et al. · 2019 · bioRxiv (Cold Spring Harbor Laboratory)
  39. A Cross-sectional Data Analysis between Serum Total Bilirubin and Potential Obesity Indices in US Adults
    Libing Tian, Jian Gang Zhang, Yanshen Chen, Yong Feng, Qing Liu, Cunbao Ling · 2025 · Current Molecular Medicine
  40. Impact of the flavonoid-induced intestinal microbiota modulation on global energy metabolism: implication for obesity
    Omar Guzmán‐Quevedo, Alana Natalícia Vasconcelos de Araújo, Pedro A. Romero-Juárez, Jordania Candice Costa Silva, Gonzalo Soria-Melgarejo, Luz Torner, Jailane de Souza Aquino · 2026 · Frontiers in Nutrition
  41. NPV-BSK805, an Antineoplastic Jak2 Inhibitor Effective in Myeloproliferative Disorders, Causes Adiposity in Mice by Interfering With the Action of Leptin
    Magalie Haissaguerre, Amandine Ferrière, Samantha Clark, Omar Guzmán‐Quevedo, Antoine Tabarin, Daniela Cota · 2018 · Frontiers in Pharmacology
  42. Microglial Proliferation in Obesity: When, Where, Why, and What Does It Mean?
    Julie Ann Chowen, Tamás L. Horváth, Jesús Argente · 2017 · Diabetes
  43. Novel Hypothalamic Mechanisms in the Pathophysiological Control of Body Weight and Metabolism
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  44. Senotherapeutic approach to age-related endocrine diseases
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  45. Dependence of fasting-induced hypothalamic anti-inflammatory microglia mechanisms on adrenal glucocorticoid secretion
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  46. Analysis of the Aerial Parts of Millettia speciosa Champ. and Mechanistic Study of Its Active Ingredient Formononetin in Improving Metabolic Syndrome
    Wenjing Niu, Ruhai Jian, Lishen Zeng, Ziyue Huang, Cai Jinyan · 2025 · Food Science & Nutrition
  47. Acute changes in systemic glycaemia gate access and action of GLP-1R agonist on brain structures controlling energy homeostasis
    Wineke Bakker, Casper Gravesen Salinas, Mónica Imbernón, Daniela Herrera Moro Chao, Rim Hassouna, Chloe Morel, Claire Martin, Giuseppe Gangarossa, R Denis, Julien Castel et al. · 2020 · bioRxiv (Cold Spring Harbor Laboratory)
  48. Efeitos da programação nutricional neonatal em células da glia hipotalâmica em ratos juvenis e adultos
    Lucas Kniess Debarba · 2018 · Digital Library of Theses and Dissertations (Universidade de São Paulo)
  49. Microglial adipobiology: a new concept for understanding the adipose tissue-brain crosstalk in health and disease
    Marin Zhelezov · 2019 · Adipobiology
  50. Investigating Antipsychotic Drug-induced Impairment of Central Energy Homeostasis
    Chantel Kowalchuk · 2019 · TSpace (University of Toronto)
  51. The Dopamine D2R Antagonist Trifluoperazine Suppresses High-Fat Diet-Induced Hyperglycemia and Hypothalamic Gliosis in Obese Mice
    Hui-Ting Huang, Pei‐Chun Chen, Po See Chen, Wen‐Tai Chiu, Yu‐Min Kuo, Shun‐Fen Tzeng · 2021 · Research Square
  52. Faculty Opinions recommendation of Microglial inflammatory signaling orchestrates the hypothalamic immune response to dietary excess and mediates obesity susceptibility.
    Shin‐ichiro Imai · 2021 · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
  53. Receptores LXR e seu papel na modulação do metabolismo e função de macrófagos residentes do tecido adiposo: uma nova ferramenta para o tratamento de doenças metabólicas
    Jéssica Aparecida da Silva Pereira · 2022 · Digital Library of Theses and Dissertations (Universidade de São Paulo)
  54. A little less heavy, or a little less hated? Exploring the consequences of a neuroinflammation model of obesity
    Joshua Reilly · 2023 · Queensland University of Technology
  55. Avaliação do papel do TGF-ß1 e da microglia na resposta inflamatória hipotalâmica induzida por ácidos graxos saturados
    Natália Ferreira Mendes · 2021
  56. Microgliosis driven by palmitate exposure alters energy metabolism and extracellular vesicles release that impact behavior and systemic metabolism
    Gabriela Cristina de Paula, Blanca I. Aldana, Roberta Battistella, Rosalía Fernández‐Calle, Andreas Bjure, Iben Lundgaard, Tomas Deierborg, João M. N. Duarte · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
  57. Reduced voluntary wheel running behaviour in Kiss1r knockout mice
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  58. Computational detection, characterization, and clustering of microglial cells in a mouse model of fat-induced postprandial hypothalamic inflammation
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  59. Neuroglia in eating disorders (obesity, Prader-Willi syndrome and anorexia nervosa)
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  60. Additional file 1 of Extracellular vesicles released from microglia after palmitate exposure impact brain function
    Gabriela Cristina de Paula, Blanca Aldana, Roberta Battistella, Rosalía Fernández‐Calle, Andreas Bjure, Iben Lundgaard, Tomas Deierborg, João M. N. Duarte · 2024 · Figshare
  61. Additional file 5 of Extracellular vesicles released from microglia after palmitate exposure impact brain function
    Gabriela Cristina de Paula, Blanca Aldana, Roberta Battistella, Rosalía Fernández‐Calle, Andreas Bjure, Iben Lundgaard, Tomas Deierborg, João M. N. Duarte · 2024 · Figshare
  62. Additional file 1 of C1q/TNF-related protein 4 restores leptin sensitivity by downregulating NF-κB signaling and microglial activation
    Ye, Liu, Jia, Gongwei, Li, Yuejie, Ying Wang, Chen, Hong, Lehua Yu, Wu, Dandong · 2021 · Figshare
  63. Additional file 3 of Microglia Sirt6 modulates the transcriptional activity of NRF2 to ameliorate high-fat diet-induced obesity
    Xiao, Xiaoxia, Huiling Hu, Zhong, Yadi, Yingjian Chen, Tang, Kaijia, Pan, Zhisen, Huang, Jiawen, Yang, Xiaoying, Qi Wang, Gao, Yong · 2024 · Figshare
  64. Additional file 2 of Extracellular vesicles released from microglia after palmitate exposure impact brain function
    Gabriela Cristina de Paula, Blanca Aldana, Roberta Battistella, Rosalía Fernández‐Calle, Andreas Bjure, Iben Lundgaard, Tomas Deierborg, João M. N. Duarte · 2024 · Figshare
  65. Additional file 4 of Extracellular vesicles released from microglia after palmitate exposure impact brain function
    Gabriela Cristina de Paula, Blanca Aldana, Roberta Battistella, Rosalía Fernández‐Calle, Andreas Bjure, Iben Lundgaard, Tomas Deierborg, João M. N. Duarte · 2024 · Figshare
  66. Additional file 6 of Microglia Sirt6 modulates the transcriptional activity of NRF2 to ameliorate high-fat diet-induced obesity
    Xiao, Xiaoxia, Huiling Hu, Zhong, Yadi, Yingjian Chen, Tang, Kaijia, Pan, Zhisen, Huang, Jiawen, Yang, Xiaoying, Qi Wang, Gao, Yong · 2024 · Figshare
  67. Additional file 5 of Microglia Sirt6 modulates the transcriptional activity of NRF2 to ameliorate high-fat diet-induced obesity
    Xiao, Xiaoxia, Huiling Hu, Zhong, Yadi, Yingjian Chen, Tang, Kaijia, Pan, Zhisen, Huang, Jiawen, Yang, Xiaoying, Qi Wang, Gao, Yong · 2024 · Figshare
  68. Additional file 3 of Extracellular vesicles released from microglia after palmitate exposure impact brain function
    Gabriela Cristina de Paula, Blanca Aldana, Roberta Battistella, Rosalía Fernández‐Calle, Andreas Bjure, Iben Lundgaard, Tomas Deierborg, João M. N. Duarte · 2024 · Figshare
  69. Additional file 1 of Sufficient Cav-1 levels in the endothelium are critical for the maintenance of the neurovascular unit in the retina
    Wang, Yixin, Mahmoud Halawa, Anupriya Chatterjee, Rachana Eshwaran, Yi Hua Qiu, Yohanes Cakrapradipta Wibowo, Pan, Jianyuan, Wieland, Thomas, Yuxi Feng · 2024 · Figshare
  70. Additional file 4 of Microglia Sirt6 modulates the transcriptional activity of NRF2 to ameliorate high-fat diet-induced obesity
    Xiao, Xiaoxia, Huiling Hu, Zhong, Yadi, Yingjian Chen, Tang, Kaijia, Pan, Zhisen, Huang, Jiawen, Yang, Xiaoying, Qi Wang, Gao, Yong · 2024 · Figshare
  71. Additional file 2 of Microglia Sirt6 modulates the transcriptional activity of NRF2 to ameliorate high-fat diet-induced obesity
    Xiao, Xiaoxia, Huiling Hu, Zhong, Yadi, Yingjian Chen, Tang, Kaijia, Pan, Zhisen, Huang, Jiawen, Yang, Xiaoying, Qi Wang, Gao, Yong · 2024 · Figshare
  72. Additional file 1 of Microglia Sirt6 modulates the transcriptional activity of NRF2 to ameliorate high-fat diet-induced obesity
    Xiao, Xiaoxia, Huiling Hu, Yadi Zhong, Yingjian Chen, Tang, Kaijia, Pan, Zhisen, Huang, Jiawen, Yang, Xiaoying, Qi Wang, Gao, Yong · 2024 · Figshare
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