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Cited by 114Birth, Development, and HealthGestational Diabetes Research and ManagementDiet, Metabolism, and Disease

Maternal Exercise Improves Glucose Tolerance in Female Offspring

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Stanford, Kristin I., Takahashi, Hirokazu, So, Kawai, Alves-Wagner, Ana Barbara, Prince, Noah B., Lehnig, Adam C., Getchell, Kristen M., Lee, Min-Young +2 more·2017·Diabetes
DOI 10.2337/db17-0098PMC PMC5521858
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Abstract

Poor maternal diet can lead to metabolic disease in offspring, whereas maternal exercise may have beneficial effects on offspring health. In this study, we determined ifmaternal exercise could reverse the detrimental effects of maternal high-fat feeding on offspring metabolism of female mice. C57BL/6 female mice were fed a chow (21%) or high-fat (60%) diet and further divided by housing in static cages or cages with running wheels for 2 weeks prior to breeding and throughout gestation. Females were bred with chow-fed sedentary C57BL/6 males. High fat–fed sedentary dams produced female offspring with impaired glucose tolerance compared with offspring of chow-fed dams throughout their first year of life, an effect not present in the offspring from high fat–fed dams that had trained. Offspring from high fat–fed trained dams had normalized glucose tolerance, decreased fasting insulin, and decreased adiposity. Liver metabolic function, measured by hepatic glucose production in isolated hepatocytes, hyperinsulinemic-euglycemic clamps, liver triglyceride content, and liver enzyme expression, was enhanced in offspring from trained dams. In conclusion, maternal exercise negates the detrimental effects of a maternal high-fat diet on glucose tolerance and hepatocyte glucose metabolism in female offspring. The ability of maternal exercise to improve the metabolic health of female offspring is important, as this intervention could combat the transmission of obesity and diabetes to subsequent generations.

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  • In offspring of high-fat diet fed dams, treadmill exercise improved the glucose tolerance of both male and female offspring.

    “In offspring of high-fat diet fed dams, treadmill exercise improved the glucose tolerance of both male and female offspring [134,135,136].”

    From Recent Experimental Studies of Maternal Obesity, Diabetes during Pregnancy and the Developmental Origins of Cardiovascular Disease (2022) · cites this paper as [135]

    The Results section (“Enhanced Glucose Tolerance in Female Versus Male Offspring”) reports improved glucose tolerance in both female and male offspring of high-fat-fed dams after maternal exercise. But “Characterization of Dams” specifies wheel running, not treadmill exercise; the supplied passages do not provide page numbers. (LLM, conf=0.90)

    Experimental — accuracy not yet measured

  • In general, the most significant effects of maternal exercise on offspring metabolic health are observed when maternal exercise begins before mating and is continued throughout pregnancy.

    “In general, the most significant effects are observed when maternal exercise begins before mating and is continued throughout pregnancy.”

    From Recent Experimental Studies of Maternal Obesity, Diabetes during Pregnancy and the Developmental Origins of Cardiovascular Disease (2022) · cites this paper as [135]

    The Results section reports that, among female offspring of high-fat-fed dams, improvements in glucose tolerance, body weight, and fat mass occurred only when dams exercised both before and during pregnancy. It also reports some improvements with exercise during gestation alone. The claim extends this finding to offspring metabolic health in general, beyond the population and conditions studied. (LLM, conf=0.85)

    Experimental — accuracy not yet measured

  • Several groups have shown that enforced maternal treadmill exercise or voluntary wheel running had significant effects on the metabolic health of male and female offspring.

    “Several groups have shown that enforced maternal treadmill exercise or voluntary wheel running had significant effects on the metabolic health of male and female offspring [131,132,133,134,135,136].”

    From Recent Experimental Studies of Maternal Obesity, Diabetes during Pregnancy and the Developmental Origins of Cardiovascular Disease (2022) · cites this paper as [135]

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Research works printed but not linked: 44

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Authors
Stanford, K. I., Takahashi, H., So, K., Alves-Wagner, A. B., Prince, N. B., Lehnig, A. C., Getchell, K. M., Lee, M.-Y., Hirshman, M. F., & Goodyear, L. J.
Affiliations
  • Brigham and Women's Hospital (US)
  • Joslin Diabetes Center (US)
  • Section on Integrative Physiology and Metabolism, Joslin Diabetes Center, Boston, MA
  • The Ohio State University Wexner Medical Center (US)
Corresponding author
Goodyear, Laurie J.
ORCID
Venue
Diabetes
Publisher
American Diabetes Association
Published
2017-06-01
Volume
66
Issue
8
Pages
2124-2136
ISSN
  • 0012-1797 (ISSN-L)
  • 1939-327X
DOI
10.2337/db17-0098
PMC
PMC5521858
OpenAlex
W2620570305
Cited by
114
References
53
Citations by year
2026: 8 · 2025: 10 · 2024: 5 · 2023: 16 · 2022: 21 · 2021: 16 · 2020: 17 · 2019: 10 · 2018: 10
FWCI
11.05
Type
journal article
Language
en
Open access
Licence
www.diabetesjournals.org/content/license (vor, 50 d)
Locations
  • Diabetes (publishedVersion)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (R01-DK101043, K01-DK-105109, 5P30-DK-36836)
  • American College of Sports Medicine
Topics
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
  • Health Sciences › Medicine › Obstetrics and Gynecology › Gestational Diabetes Research and Management
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diet, Metabolism, and Disease
Keywords
maternal physical activity, maternal high-fat diet, glucose tolerance, female offspring, offspring metabolic health, hepatic glucose production, fasting insulin, adiposity, obesity
MeSH terms
Animals, Fasting, Female, Glucose, Insulin, Liver, Mice, Inbred C57BL, Physical Conditioning, Animal, Pregnancy, Prenatal Exposure Delayed Effects, Sex Factors, Triglycerides, Glucose Clamp Technique, Glucose Intolerance, Maternal Nutritional Physiological Phenomena, Adiposity, Mice, Diet, High-Fat

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