The Effect of Intensive Diabetes Treatment on Resting Heart Rate in Type 1 Diabetes
Open accessAbstract
OBJECTIVE: Cardiovascular disease is a major cause of morbidity and mortality in individuals with type 1 diabetes. Resting heart rate (RHR) is a risk factor for cardiovascular disease in the general population, and case-control studies have reported a higher RHR in individuals with type 1 diabetes. In individuals with type 1 diabetes, there is a positive correlation between A1C and RHR; however, no prospective studies have examined whether a causal relationship exists between A1C and RHR. We hypothesized that intensive diabetes treatment aimed to achieve normal A1C levels has an effect on RHR in individuals with type 1 diabetes. RESEARCH DESIGN AND METHODS: A total of 1,441 individuals with type 1 diabetes who participated in the Diabetes Control and Complications Trial (DCCT) had their RHR measured biennially by an electrocardiogram during the DCCT and annually for 10 years during the Epidemiology of Diabetes Interventions and Complications (EDIC) follow-up study. RESULTS: During the DCCT, intensive treatment was associated with lower mean RHR than conventional treatment, both in adolescents (69.0 vs. 72.0 bpm [95% CI 62.8-75.7 and 65.7-78.9, respectively], P = 0.013) and adults (66.8 vs. 68.2 [65.3-68.4 and 66.6-69.8, respectively], P = 0.0014). During follow-up in the EDIC, the difference in RHR between the treatment groups persisted for at least 10 years (P < 0.0001). CONCLUSIONS: Compared with conventional therapy, intensive diabetes management is associated with lower RHR in type 1 diabetes. The lower RHR with intensive therapy may explain, in part, its effect in reducing cardiovascular disease, recently demonstrated in type 1 diabetes.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Exercise training improves cardiac autonomic neuropathy in type 2 diabetes.
“exercise training improves cardiac autonomic neuropathy in type 2 diabetes (15,16).”
From Obstructive Sleep Apnea, Resting Heart Rate, and Glycemic Variability in Adults With Maturity-Onset Diabetes of the Young (2026) · cites this paper as [16]
The Abstract reports that intensive diabetes treatment was associated with a lower resting heart rate in people with type 1 diabetes. Searches for exercise training and cardiac autonomic neuropathy in type 2 diabetes found no passage addressing that claim; the different treatment and population do not establish a contrary finding. (LLM, conf=0.76)
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
The citation lists haven’t been fetched yet
References 46 · Cited by 81
- Authors
- Paterson, A. D., Rutledge, B. N., Cleary, P. A., Lachin, J. M., Crow, R. S., & for the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Research Group
- Affiliations
- University of Toronto (CA)
- George Washington University (US)
- University of Minnesota (US)
- Venue
- Diabetes Care
- Publisher
- American Diabetes Association
- Published
- 2007-08-01
- Volume
- 30
- Issue
- 8
- Pages
- 2107-2112
- ISSN
- 0149-5992 (ISSN-L)
- 1935-5548
- PMC
- PMC2654598
- OpenAlex
- W2140663625
- Cited by
- 81
- References
- 46
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 2 · 2023: 2 · 2022: 1 · 2021: 8 · 2020: 3 · 2019: 5 · 2018: 3 · 2017: 4 · 2016: 4 · 2015: 3 · 2014: 5 · 2013: 6 · 2012: 5
- FWCI
- 4.63
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Diabetes Care (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (n01dk062204-003)
- National Institute of Diabetes and Digestive and Kidney Diseases (N01 DK062204, N01‐DK‐6‐2204)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Keywords
- type 1 diabetes, resting heart rate, intensive diabetes treatment, glycemic control, HbA1c, cardiovascular risk, Diabetes Control and Complications Trial, cardiovascular disease prevention
- MeSH terms
- Adolescent, Adult, Diabetes Mellitus, Type 1, Diabetic Angiopathies, Electrocardiography, Follow-Up Studies, Heart Rate, Humans, Least-Squares Analysis, Age of Onset, Patient Selection
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
