Cited by 730Gestational Diabetes Research and ManagementBirth, Development, and HealthPancreatic function and diabetes

The DOI matches its Crossref record; 35 of the 35 references it cites were found in a registry or an index.

High Prevalence of Type 2 Diabetes and Pre-Diabetes in Adult Offspring of Women With Gestational Diabetes Mellitus or Type 1 Diabetes

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Abstract

OBJECTIVE—The role of intrauterine hyperglycemia and future risk of type 2 diabetes in human offspring is debated. We studied glucose tolerance in adult offspring of women with either gestational diabetes mellitus (GDM) or type 1 diabetes, taking the impact of both intrauterine hyperglycemia and genetic predisposition to type 2 diabetes into account. RESEARCH DESIGN AND METHODS—The glucose tolerance status following a 2-h 75-g oral glucose tolerance test (OGTT) was evaluated in 597 subjects, primarily Caucasians, aged 18–27 years. They were subdivided into four groups according to maternal glucose metabolism during pregnancy and genetic predisposition to type 2 diabetes: 1) offspring of women with diet-treated GDM (O-GDM), 2) offspring of genetically predisposed women with a normal OGTT (O-NoGDM), 3) offspring of women with type 1 diabetes (O-type 1), and 4) offspring of women from the background population (O-BP). RESULTS—The prevalence of type 2 diabetes and pre-diabetes (impaired glucose tolerance or impaired fasting glucose) in the four groups was 21, 12, 11, and 4%, respectively. In multiple logistic regression analysis, the adjusted odds ratios (ORs) for type 2 diabetes/pre-diabetes were 7.76 (95% CI 2.58–23.39) in O-GDM and 4.02 (1.31–12.33) in O-type 1 compared with O-BP. In O-type 1, the risk of type 2 diabetes/pre-diabetes was significantly associated with elevated maternal blood glucose in late pregnancy: OR 1.41 (1.04–1.91) per mmol/l. CONCLUSIONS—A hyperglycemic intrauterine environment appears to be involved in the pathogenesis of type 2 diabetes/pre-diabetes in adult offspring of primarily Caucasian women with either diet-treated GDM or type 1 diabetes during pregnancy.

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Metadata

Authors
Clausen, T. D., Mathiesen, E. R., Hansen, T., Pedersen, O., Jensen, D. M., Lauenborg, J., & Damm, P.
Affiliations
  • Copenhagen University Hospital (DK)
  • Steno Diabetes Center Copenhagen (DK)
  • Odense University Hospital (DK)
Venue
Diabetes Care
Published
2008-02-01
Volume
31
Issue
2
Pages
340-346
ISSN
  • 0149-5992 (ISSN-L)
  • 1935-5548
OpenAlex
W2102302842
Cited by
724
References
35
Citations by year
2026: 25 · 2025: 30 · 2024: 49 · 2023: 46 · 2022: 62 · 2021: 56 · 2020: 41 · 2019: 46 · 2018: 63 · 2017: 38 · 2016: 45 · 2015: 34 · 2014: 31 · 2013: 33 · 2012: 28
FWCI
37.09
Type
journal article
Language
en
Open access
Locations
  • Diabetes Care (publishedVersion)
  • PubMed (publishedVersion)
  • Research at the University of Copenhagen (University of Copenhagen) (submittedVersion)
  • University of Southern Denmark Research Portal (University of Southern Denmark) (submittedVersion)
Topics
  • Health Sciences › Medicine › Obstetrics and Gynecology › Gestational Diabetes Research and Management
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pancreatic function and diabetes
Keywords
type 2 diabetes, prediabetes, gestational diabetes mellitus, type 1 diabetes, intrauterine hyperglycemia, adult offspring, glucose tolerance, impaired glucose tolerance, impaired fasting glucose
MeSH terms
Adult, Denmark, Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2, Female, Glucose Tolerance Test, Humans, Hyperglycemia, Prediabetic State, Pregnancy, Pregnancy Complications, Regression Analysis, Smoking, Diabetes, Gestational, Genetic Predisposition to Disease, Overweight

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