The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Hypoglycemia Increases Serum Interleukin-6 Levels in Healthy Men and Women
Abstract
OBJECTIVE—Inflammation may have a major role in the pathogenesis and prognosis of critical illness. Hyperglycemia increases levels of the inflammatory cytokine interleukin-6 (IL-6) and is associated with increased risks of morbidity and mortality. Because hypoglycemia is also associated with adverse outcomes, we tested the hypothesis that hypoglycemia increases IL-6. RESEARCH DESIGN AND METHODS—Seventeen healthy men and women participated in hypoglycemic and euglycemic-hyperinsulinemic clamp studies (target blood glucose levels 2.7 and 5.0 mmol/l, respectively), separated by 1–3 months. IL-6, ACTH, and cortisol were measured at baseline and at 45, 75, 105, and 135 min after initiation of the insulin infusion. RESULTS—IL-6, ACTH, and cortisol levels increased significantly (P < 0.0001) during hypoglycemia but not euglycemia. IL-6 increased from mean ± SEM 1.0 ± 0.2 pg/ml at baseline to 2.6 ± 0.2 pg/ml after 135 min of hypoglycemia, whereas IL-6 levels were unchanged during euglycemia. CONCLUSIONS—Hypoglycemia increases IL-6 levels in healthy individuals.
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“Hypoglycemia is a paradigmatic metabolic physiological stress that evokes autonomic, neuroendocrine, and immune responses that are mediated by the same systems activated by psychosocial stress”
From Stress, hypoglycemia, and the autonomic nervous system (2022) · cites this paper as Dotson et al., 2008
In the citing paper
“though interleukin (IL)-6 demonstrates the most prominent and consistent increase across studies”
From Stress, hypoglycemia, and the autonomic nervous system (2022) · cites this paper as Dotson et al., 2008
In the citing paper
“Acute hypoglycemia has been demonstrated to increase inflammatory markers, prolong QTc, and impair cardiac-vagal baroreflex sensitivity.”
From Stress, hypoglycemia, and the autonomic nervous system (2022) · cites this paper as Dotson et al., 2008
In the citing paper
“Hypoglycemia increases hypothalamic release of CRH and vasopressin into the hypophyseal portal system leading to increases in pituitary ACTH, which then stimulates the adrenal gland to secrete adrenal steroids (including cortisol and aldosterone).”
From Stress, hypoglycemia, and the autonomic nervous system (2022) · cites this paper as Dotson et al., 2008
In the citing paper
“Increases in glucagon, epinephrine, growth hormone, and cortisol compose the main counterregulatory response that serves to restore glucose levels to normal.”
From Stress, hypoglycemia, and the autonomic nervous system (2022) · cites this paper as Dotson et al., 2008
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Esposito, K., Nappo, F., Marfella, R., Giugliano, G., Giugliano, F., Ciotola, M., Quagliaro, L., Ceriello, A., & Giugliano, D. (2002) · Circulation · doi:10.1161/01.cir.0000034509.14906.ae · Cited by 1,961
Dose-Dependent Effects of Recombinant Human Interleukin-6 on Glucose Regulation
Tsigos, C., Papanicolaou, D. A., Kyrou, I., Defensor, R., Mitsiadis, C. S., & Chrousos, G. P. (1997) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.82.12.4422 · Cited by 324
Research works printed but not linked: 5
- Wasmuth HE, Kunz D, Graf J, Stanzel S, Purucker EA, Koch A, Gartung C, Heintz B, Gressner AM, Matern S, Lammert F: Hyperglycemia at admission to the intensive care unit is associated with elevated serum concentrations of interleukin-6 and reduced ex vivo secretion of tumor necrosis factor-α. Crit Care Med 32:1109–1114, 2004 · DOI
- Vanhorebeek I, Langouche L, Van den Berghe G: Tight blood glucose control with insulin in the ICU: facts and controversies. Chest 132:268–278, 2007 · DOI
- Krogh-Madsen R, Møller K, Dela F, Kronborg G, Jauffred S, Pedersen BK: Effect of hyperglycemia and hyperinsulinemia on the response of IL-6, TNF-α, and FFAs to low-dose endotoxemia in humans. Am J Physiol Endocrinol Metab 286:E766–E772, 2004 · DOI
- de Galan BE, Netea MG, Smits P, van der Meer JWM: Hypoglycaemia downregulates endotoxin-induced production of tumour necrosis factor-α, but does not affect IL-1β, IL-6, or IL-10. Cytokine 22:71–76, 2003 · DOI
- Kristiansen OP, Mandrup-Poulsen T: Interleukin-6 and diabetes: the good, the bad, or the indifferent? Diabetes 54 (Suppl. 2):S114–S124, 2005 · DOI
Cited by
Hypoglycemia and outcome in critically ill patients
Egi, M., Bellomo, R., Stachowski, E., French, C. J., Hart, G. K., Taori, G., Hegarty, C., & Bailey, M. (2010) · Mayo Clinic Proceedings · doi:10.4065/mcp.2009.0394 · Cited by 432
Gogitidze Joy, N., Hedrington, M. S., Briscoe, V. J., Tate, D. B., Ertl, A. C., & Davis, S. N. (2010) · Diabetes Care · doi:10.2337/dc09-0354 · Cited by 239
Treatment-induced diabetic neuropathy: A reversible painful autonomic neuropathy
Gibbons, C. H., & Freeman, R. (2010) · Annals of Neurology · doi:10.1002/ana.21952 · Cited by 213
Self-citationEffects of Acute Insulin-Induced Hypoglycemia on Indices of Inflammation
Wright, R. J., Newby, D. E., Stirling, D., Ludlam, C. A., Macdonald, I. A., & Frier, B. M. (2010) · Diabetes Care · doi:10.2337/dc10-0013 · Cited by 208
Proinflammatory effects of hypoglycemia in humans with or without diabetes
Ratter, J. M., Rooijackers, H. M. M., Tack, C. J., Hijmans, A. G. M., Netea, M. G., de Galan, B. E., & Stienstra, R. (2017) · Diabetes · doi:10.2337/db16-1091 · Cited by 94
Metadata
- Authors
- Dotson, S., Freeman, R., Failing, H. J., & Adler, G. K.
- Affiliations
- Division of Endocrinology, Diabetes, and Hypertension, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts
- Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts
- Venue
- Diabetes Care
- Publisher
- American Diabetes Association
- Published
- 2008-06-01
- Volume
- 31
- Issue
- 6
- Pages
- 1222-1223
- ISSN
- 0149-5992
- 1935-5548
- Cited by
- 70
- References
- 2
- Language
- en
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