The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Effects of Thyroid Hormone on A1C and Glycated Albumin Levels in Nondiabetic Subjects With Overt Hypothyroidism
Open accessAbstract
OBJECTIVE: We aimed to determine the effects of thyroid hormone on A1C and glycated albumin (GA) in nondiabetic patients with overt hypothyroidism. RESEARCH DESIGN AND METHODS: A1C levels were measured in 45 nondiabetic patients with overt hypothyroidism and 180 euthyroid control subjects. A1C, GA, fasting blood glucose (FBG), 1,5-anhydroglucitol, and erythrocyte indexes were determined in 30 nondiabetic patients with overt hypothyroidism before and after thyroid hormone replacement. RESULTS: A1C levels were higher in patients with hypothyroidism compared with control subjects. A1C levels were decreased by thyroid hormone replacement. Thyroid hormone replacement increased serum erythropoietin, reticulocyte count, and mean corpuscular hemoglobin (MCH). The change in A1C level was significantly correlated with the change in reticulocyte count or MCH. Thyroid hormone replacement decreased serum levels of albumin and GA. However, FBG and 1,5-anhydroglucitol levels were not altered. CONCLUSIONS: Levels of A1C and GA are spuriously high in nondiabetic patients with overt hypothyroidism.
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Hypothyroidism can exacerbate cardiovascular risk factors (such as dyslipidemia) by increasing cholesterol levels, particularly low-density lipoprotein cholesterol.
“Hypothyroidismcanexacerbatecardiovascularriskfactors(such as dyslipidemia) by increasing cholesterol levels, particularly lowdensity lipoprotein cholesterol, and is associated with diastolic hypertension, increasing the likelihood of cardiovascular disease, particularly in patients with diabetes. 45,46”
From Hypothyroidism: A Review (2025) · cites this paper as [46]
The Results (Table 1; page unavailable) show that total cholesterol fell after thyroid hormone replacement in 30 nondiabetic patients with overt hypothyroidism, supporting the cholesterol component. The paper does not report LDL cholesterol or establish that hypothyroidism increased cardiovascular risk; its findings do not extend to patients with diabetes. (LLM, conf=0.86)
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Diagnosis and classification of diabetes mellitus
American Diabetes Association (2010) · Diabetes Care · doi:10.2337/dc10-s062 · Cited by 5,491
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Research works printed but not linked: 11
- Koga, 2009, Effects of thyroid hormone on serum glycated albumin levels: study on non-diabetic subjects, Diabetes Res Clin Pract, 84, 163, 10.1016/j.diabres.2009.01.013 · DOI
- Fitzgibbons, 1976, Red cell age-related changes of hemoglobins A1a+b and A1C in normal and diabetic subjects, J Clin Invest, 58, 820, 10.1172/JCI108534 · DOI
- McGill, 2006, Anemia and the role of erythropoietin in diabetes, J Diabetes Complications, 20, 262, 10.1016/j.jdiacomp.2005.08.001 · DOI
- Gram-Hansen, 1990, Glycosylated hemoglobin (HbA1c) in iron- and vitamin B12 deficiency, J Intern Med, 227, 133, 10.1111/j.1365-2796.1990.tb00131.x · DOI
- Hashimoto, 2008, A1C but not serum glycated albumin is elevated in late pregnancy owing to iron deficiency, Diabetes Care, 31, 1945, 10.2337/dc08-0352 · DOI
- Fein, 1975, Anemia in thyroid diseases, Med Clin North Am, 59, 1133, 10.1016/S0025-7125(16)31963-0 · DOI
- Cinemre, 2009, Hematologic effects of levothyroxine in iron-deficient subclinical hypothyroid patients: a randomized, double-blind, controlled study, J Clin Endocrinol Metab, 94, 151, 10.1210/jc.2008-1440 · DOI
- Larsen, 2002, Hypothyroidism and thyroiditis, 423
- Handisurya, 2008, Effects of T4 replacement therapy on glucose metabolism in subjects with subclinical (SH) and overt hypothyroidism (OH), Clin Endocrinol (Oxf), 69, 963, 10.1111/j.1365-2265.2008.03280.x · DOI
- Maratou, 2009, Studies of insulin resistance in patients with clinical and subclinical hypothyroidism, Eur J Endocrinol, 160, 785, 10.1530/EJE-08-0797 · DOI
- Dungan, 2006, 1,5-anhydroglucitol and postprandial hyperglycemia as measured by continuous glucose monitoring system in moderately controlled patients with diabetes, Diabetes Care, 29, 1214, 10.2337/dc06-1910 · DOI
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Chaker, L., & Papaleontiou, M. (2025) · JAMA · doi:10.1001/jama.2025.13559 · Cited by 63
Metadata
- Authors
- Kim, M. K., Kwon, H. S., Baek, K.-H., Lee, J. H., Park, W. C., Sohn, H. S., Lee, K.-W., & Song, K.-H.
- Affiliations
- Catholic University of Korea (KR)
- Corresponding author
- Song, Ki-Ho
- Venue
- Diabetes Care
- Publisher
- American Diabetes Association
- Published
- 2010-09-07
- Volume
- 33
- Issue
- 12
- Pages
- 2546-2548
- ISSN
- 0149-5992 (ISSN-L)
- 1935-5548
- PMC
- PMC2992186
- OpenAlex
- W2155302843
- Cited by
- 76
- References
- 1
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 8 · 2023: 6 · 2022: 5 · 2021: 3 · 2020: 11 · 2019: 7 · 2018: 4 · 2017: 5 · 2016: 8 · 2015: 3 · 2014: 5 · 2013: 3 · 2012: 1
- FWCI
- 1.45
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Diabetes Care (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Funders
- Korean Diabetes Association
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
- Health Sciences › Health Professions › Medical Laboratory Technology › Clinical Laboratory Practices and Quality Control
- Keywords
- overt hypothyroidism, thyroid hormone replacement, HbA1c, glycated albumin, red blood cell indices, reticulocyte count, mean corpuscular hemoglobin, erythropoietin, 1,5-anhydroglucitol, non-diabetic patients
- MeSH terms
- Adult, Cross-Sectional Studies, Erythrocyte Indices, Erythropoietin, Female, Glycated Hemoglobin, Humans, Hypothyroidism, Iodine Radioisotopes, Male, Middle Aged, Serum Albumin, Thyroid Hormones, Reticulocyte Count
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