The DOI matches its Crossref record; 37 of the 37 references it cites were found in a registry or an index.
Metabolically Healthy Obesity and Risk of Mortality
Open accessAbstract
OBJECTIVE: To assess the association of a “metabolically healthy obese” phenotype with mortality using five definitions of metabolic health. RESEARCH DESIGN AND METHODS: Adults (n = 5,269; 71.7% men) aged 39–62 years in 1991 through 1993 provided data on BMI and metabolic health, defined using data from the Adult Treatment Panel-III (ATP-III); criteria from two studies; and the Matsuda and homeostasis model assessment (HOMA) indices. Cross-classification of BMI categories and metabolic status (healthy/unhealthy) created six groups. Cox proportional hazards regression models were used to analyze associations with all-cause and cardiovascular disease (CVD) mortality during a median follow-up of 17.7 years. RESULTS: A total of 638 individuals (12.1% of the cohort) were obese, of whom 9–41% were metabolically healthy, depending on the definition. Regardless of the definition, compared with metabolically healthy, normal-weight individuals, both the metabolically healthy obese (hazard ratios [HRs] ranged from 1.81 [95% CI 1.16–2.84] for ATP-III to 2.30 [1.13–4.70] for the Matsuda index) and the metabolically abnormal obese (HRs ranged from 1.57 [1.08–2.28] for the Matsuda index to 2.05 [1.44–2.92] for criteria defined in a separate study) had an increased risk of mortality. The only exception was the lack of excess risk using the HOMA criterion for the metabolically healthy obese (1.08; 0.67–1.74). Among the obese, the risk of mortality did not vary as a function of metabolic health apart from when using the HOMA criterion (1.93; 1.15–3.22). Similar results were obtained for cardiovascular mortality. CONCLUSIONS: For most definitions of metabolic health, both metabolically healthy and unhealthy obese patients carry an elevated risk of mortality.
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Metabolically healthy obesity: Epidemiology, mechanisms, and clinical implications
Stefan, N., Häring, H.-U., Hu, F. B., & Schulze, M. B. (2013) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(13)70062-7 · Cited by 857
Obesity and cardiovascular disease: revisiting an old relationship
Koliaki, C., Liatis, S., & Kokkinos, A. (2019) · Metabolism · doi:10.1016/j.metabol.2018.10.011 · Cited by 719
Epidemiological modifiers of non-alcoholic fatty liver disease: Focus on high-risk groups
Lonardo, A., Bellentani, S., Argo, C. K., Ballestri, S., Byrne, C. D., Caldwell, S. H., Cortez-Pinto, H., Grieco, A., Machado, M. V., Miele, L., et al. (2015) · Digestive and Liver Disease · doi:10.1016/j.dld.2015.08.004 · Cited by 444
Metabolically healthy obesity and cardiovascular events: a systematic review and meta-analysis.
Eckel, N., Meidtner, K., Kalle-Uhlmann, T., Stefan, N., & Schulze, M. B. (2016) · European Journal of Preventive Cardiology · doi:10.1177/2047487315623884 · Cited by 405
Hinnouho, G.-M., Czernichow, S., Dugravot, A., Nabi, H., Brunner, E. J., Kivimaki, M., & Singh-Manoux, A. (2015) · European Heart Journal · doi:10.1093/eurheartj/ehu123 · Cited by 366
Self-citation
Metadata
- Authors
- Hinnouho, G.-M., Czernichow, S., Dugravot, A., Batty, G. D., Kivimaki, M., & Singh-Manoux, A.
- Venue
- Diabetes Care
- Publisher
- American Diabetes Association
- Published
- 2013-07-11
- Volume
- 36
- Issue
- 8
- Pages
- 2294-2300
- ISSN
- 0149-5992 (ISSN-L)
- 1935-5548
- OpenAlex
- W2170088180
- Cited by
- 317
- References
- 37
- FWCI
- 23.82
- Type
- journal article
- Language
- en
- Open access
- hybrid
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