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Food Order Has a Significant Impact on Postprandial Glucose and Insulin Levels

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Shukla, Alpana P., Iliescu, Radu G., Thomas, Catherine E., Aronne, Louis J.·2015·Diabetes Care

DOI 10.2337/dc15-0429PMC PMC4876745

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Abstract

Postprandial hyperglycemia is an important therapeutic target for optimizing glycemic control and for mitigating the proatherogenic vascular environment characteristic of type 2 diabetes. Existing evidence indicates that the quantity and type of carbohydrate consumed influence blood glucose levels and that the total amount of carbohydrate consumed is the primary predictor of glycemic response (1). Previous studies have shown that premeal ingestion of whey protein, as well as altering the macronutrient composition of a meal, reduces postmeal glucose levels (2–4). There are limited data, however, regarding the effect of food order on postprandial glycemia in patients with type 2 diabetes (5). In this pilot study, we sought to examine the effect of food order, using a typical Western meal, incorporating vegetables, protein, and carbohydrate, on postprandial glucose and insulin excursions in overweight/obese adults with type 2 diabetes. A total of 11 subjects (6 female, 5 male) with metformin-treated type 2 diabetes were studied …

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Authors: Shukla, A. P., Iliescu, R. G., Thomas, C. E., & Aronne, L. J.
Affiliations: Weill Cornell Medicine (US)
Corresponding author: Shukla, Alpana P.
ORCID: Shukla, Alpana P.
Aronne, Louis J.
Venue: Diabetes Care
Publisher: American Diabetes Association
Published: 2015-06-11
Volume: 38
Issue: 7
Pages: e98-e99
ISSN: 0149-5992 (ISSN-L)
1935-5548
DOI: 10.2337/dc15-0429
PMC: PMC4876745
OpenAlex: W2098825026
Cited by: 104
References: 6
Citations by year: 2026: 15 · 2025: 11 · 2024: 11 · 2023: 7 · 2022: 15 · 2021: 7 · 2020: 8 · 2019: 6 · 2018: 9 · 2017: 6 · 2016: 6 · 2015: 3
FWCI: 6.95
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Diabetes Care (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (UL1TR000457)
Weill Cornell Medical College (UL1 TR000457)
National Center for Advancing Translational Sciences
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Keywords: postprandial blood glucose, postprandial insulin, type 2 diabetes, postprandial hyperglycemia, meal composition, overweight and obesity, glycemic control

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Food Order Has a Significant Impact on Postprandial Glucose and Insulin Levels

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