Exposure to Gestational Diabetes Mellitus: Impact on the Development of Early-Onset Type 2 Diabetes in Canadian First Nations and Non-First Nations Offspring
Abstract
OBJECTIVE: Type 2 diabetes is increasing in children worldwide, with Canadian First Nations (FN) children disproportionally affected. The prevalence of gestational diabetes mellitus (GDM) also is increasing. The objective of this study was to evaluate the impact of GDM exposure in utero and FN status on the subsequent risk of type 2 diabetes in offspring in the first 30 years of life. RESEARCH DESIGN AND METHODS: In this population-based historical prospective cohort study, we used administrative databases linked to a clinical database to explore the independent association and interaction between GDM and FN status on the subsequent development of type 2 diabetes in offspring. RESULTS: Among 321,008 births with a median follow-up of 15.1 years, both maternal GDM and FN status were independently associated with subsequent risk of type 2 diabetes in offspring in the first 30 years of life (hazard ratio 3.03 [95% CI 2.44–3.76; P < 0.0001] vs. 4.86 [95% CI 4.08–5.79; P < 0.0001], respectively). No interaction between GDM and FN status on type 2 diabetes risk was observed. FN status had a stronger impact on the development of type 2 diabetes in offspring than GDM. CONCLUSIONS: GDM is an important modifiable risk factor for type 2 diabetes, and its prevention may reduce the prevalence of subsequent type 2 diabetes in offspring. This study adds unique and rigorous evidence to the global public health debate about the impact of GDM on the long-term health of offspring.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Diabetes during pregnancy predisposes offspring for the development of obesity, type 2 diabetes and cardiometabolic disease risk factors.
“Diabetes during pregnancy also predisposes offspring for the development of obesity, T2D and cardiometabolic disease risk factors [33,70,71,72,73,74,75,76,77] (Figure 1).”
From Recent Experimental Studies of Maternal Obesity, Diabetes during Pregnancy and the Developmental Origins of Cardiovascular Disease (2022) · cites this paper as [72]
Cites
Dabelea, D., Hanson, R. L., Lindsay, R. S., Pettitt, D. J., Imperatore, G., Gabir, M. M., Roumain, J., Bennett, P. H., & Knowler, W. C. (2000) · Diabetes · doi:10.2337/diabetes.49.12.2208 · Cited by 1,277 · see citing works
Lawrence, J. M., Contreras, R., Chen, W., & Sacks, D. A. (2008) · Diabetes Care · doi:10.2337/dc07-2345 · Cited by 658 · see citing works
Association of Intrauterine Exposure to Maternal Diabetes and Obesity With Type 2 Diabetes in Youth
Dabelea, D., Mayer-Davis, E. J., Lamichhane, A. P., D'Agostino, R. B., Liese, A. D., Vehik, K. S., Narayan, K. M. V., Zeitler, P., & Hamman, R. F. (2008) · Diabetes Care · doi:10.2337/dc07-2417 · Cited by 415 · see citing works
Dyck, R., Klomp, H., Tan, L. K., Turnell, R. W., & Boctor, M. A. (2002) · Diabetes Care · doi:10.2337/diacare.25.3.487 · Cited by 176 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Ethnic disparities in gestational diabetes
Yuen, L., Wong, V. W., & Simmons, D. (2018) · Current Diabetes Reports · doi:10.1007/s11892-018-1040-2 · Cited by 88 · see citing works
Wicklow, B. A., Sellers, E. A. C., Sharma, A. K., Kroeker, K., Nickel, N. C., Philips-Beck, W., & Shen, G. X. (2018) · JAMA Pediatrics · doi:10.1001/jamapediatrics.2018.1201 · Cited by 88 · see citing works
Self-citationKereliuk, S. M., & Dolinsky, V. W. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23084467 · Cited by 34 · see citing works
Chen, L., Wang, W.-J., Auger, N., Xiao, L., Torrie, J., McHugh, N. G.-L., & Luo, Z.-C. (2019) · BMJ Open · doi:10.1136/bmjopen-2018-025084 · Cited by 30 · see citing works
Physical activity throughout pregnancy is key to preventing chronic disease
S Nagpal, T., & F Mottola, M. (2020) · Reproduction · doi:10.1530/rep-20-0337 · Cited by 29 · see citing works
- Authors
- Sellers, E. A. C., Dean, H. J., Shafer, L. A., Martens, P. J., Phillips-Beck, W., Heaman, M., Prior, H. J., Dart, A. B., McGavock, J., Morris, M., Torshizi, A. A., Ludwig, S., & Shen, G. X.
- Affiliations
- Children's Hospital Research Institute of Manitoba (CA)
- University of Manitoba (CA)
- Assembly of Manitoba Chiefs (CA)
- Corresponding author
- Sellers, Elizabeth A.C.
- ORCID
- Venue
- Diabetes Care
- Publisher
- American Diabetes Association
- Published
- 2016-10-04
- Volume
- 39
- Issue
- 12
- Pages
- 2240-2246
- ISSN
- 0149-5992 (ISSN-L)
- 1935-5548
- OpenAlex
- W2529650538
- Cited by
- 71
- References
- 4
- Citations by year
- 2026: 7 · 2025: 8 · 2024: 8 · 2023: 6 · 2022: 7 · 2021: 4 · 2020: 11 · 2019: 6 · 2018: 9 · 2017: 4 · 2016: 1
- FWCI
- 8.61
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Diabetes Care (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Canadian Institutes for Health Research (CIHR, SEC117115)
- Topics
- Health Sciences › Medicine › Obstetrics and Gynecology › Gestational Diabetes Research and Management
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Keywords
- gestational diabetes mellitus, type 2 diabetes, early-onset type 2 diabetes, First Nations, Indigenous health, offspring diabetes risk, diabetes prevention, modifiable risk factors
- MeSH terms
- Adolescent, Adult, Canada, Child, Diabetes Mellitus, Type 2, Female, Humans, Indians, North American, Infant, Newborn, Male, Pregnancy, Prenatal Exposure Delayed Effects, Prospective Studies, Risk Factors, Cohort Studies, Prevalence, Diabetes, Gestational, Age of Onset, Young Adult
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
