Cannabis Use Is Associated With Increased Risk for Diabetic Ketoacidosis in Adults With Type 1 Diabetes: Findings From the T1D Exchange Clinic Registry
Abstract
Objective We examined the frequency of diabetic ketoacidosis (DKA) in cannabis users compared with nonusers in the T1D Exchange clinic registry (T1DX). Research design and methods The association between cannabis use by total substance score for cannabis (TSC) and DKA in the past 12 months was examined using a logistic regression model adjusted for potential confounders among adults in the T1DX. Results Of 932 adults with type 1 diabetes, 61 had a TSC >4, which classified them as moderate cannabis users. Adjusting for sex, age at study visit, and HbA 1c , cannabis use was associated with a twofold increase in risk for DKA among adults with type 1 diabetes (odds ratio 2.5 [95% CI 1.0-5.9]). Conclusions Cannabis use was associated with an increased risk for DKA among adults in the T1DX. Providers should inform their patients of the potential risk of DKA with cannabis use.
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Factors associated with increased risk of DKA that are potentially modifiable include having had one previous episode of DKA, high HbA1c, low self-management skills, psychiatric disorders, infections, somatic comorbidity, alcohol and drug abuse, and less interaction with the health care team.
“These include having had one previous episode of DKA, high HbA 1c , low self-management skills (including omission of insulin therapy), psychiatric disorders, infections, somatic comorbidity, alcohol and drug abuse and less interaction with the health care team (211-213).”
Cites
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- Authors
- Kinney, G. L., Akturk, H. K., Taylor, D. D., Foster, N. C., & Shah, V. N.
- Affiliations
- Colorado School of Public Health (US)
- Barbara Davis Center for Diabetes, University of Colorado Anschutz Medical Campus, Aurora, CO
- Jaeb Center for Health Research (US)
- University of Colorado Anschutz (US)
- Corresponding author
- Kinney, Gregory L.
- Venue
- Diabetes Care
- Publisher
- American Diabetes Association
- Published
- 2019-10-18
- Volume
- 43
- Issue
- 1
- Pages
- 247-249
- ISSN
- 0149-5992 (ISSN-L)
- 1935-5548
- OpenAlex
- W2980449939
- Cited by
- 51
- References
- 1
- Citations by year
- 2026: 4 · 2025: 7 · 2024: 10 · 2023: 5 · 2022: 5 · 2021: 11 · 2020: 9
- FWCI
- 5.09
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Diabetes Care (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
- Health Sciences › Medicine › Pharmacology › Cannabis and Cannabinoid Research
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Education
- Keywords
- cannabis use, diabetic ketoacidosis, type 1 diabetes, adults with type 1 diabetes, substance use, risk factors, HbA1c
- MeSH terms
- Adolescent, Adult, Cannabis, Marijuana Abuse, Diabetes Mellitus, Type 1, Female, Humans, Male, Marijuana Smoking, Registries, Risk Factors, Diabetic Ketoacidosis, Young Adult
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