Safety of Real-life Usage of Advanced Hybrid Closed-Loop System MiniMed 780G in Children With Type 1 Diabetes Younger Than 7 Years Old
Open accessAbstract
Table 1-Sensor-specific measures of glycemic control, adherence to advanced hybrid closed loop (a-HCL) use, insulin dose and basal-to-bolus ratio
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This finding supports previous studies demonstrating a correlation of percent time in range with more aggressive correction targets.
“This finding supports previous studies demonstrating a correlation of %TIR with more aggressive correction targets.19 20”
From Clinical utility of the twiist Automated Insulin Delivery System: first study with twiist (2026) · cites this paper as [20]
The results passage (page not provided) reports increased %TIR after Auto Mode began and says that most children later used lower glucose targets. Table 1 tracks both measures over time, but the paper does not demonstrate a correlation between %TIR and more aggressive targets; the initial TIR increase occurred before the reported shift to lower targets. (LLM, conf=0.82)
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Research works printed but not linked: 5
- [1]Pulkkinen MA, Varimo TJ, Hakonen ET,. MiniMed 780G in 2- to 6-year-old children: safety and clinical outcomes after the first 12 weeks. Diabetes Technol Ther 2023; 25: 100– 107 36511831
- [2]Tekielak A, Seget S, Rusak E, Jarosz-Chobot P. Can the AHCL system be used in T1D patients with borderline TDDI? A case report. Sensors (Basel) 2021; 21: 7195 34770502 PMC8587306
- [3]Ferguson SC, Blane A, Wardlaw J,. Influence of an early-onset age of type 1 diabetes on cerebral structure and cognitive function. Diabetes Care 2005; 28: 1431– 1437 15920064
- [4]Mauras N, Buckingham B, White NH,.; Diabetes Research in Children Network (DirecNet). Impact of type 1 diabetes in the developing brain in children: a longitudinal study. Diabetes Care 2021; 44: 983– 992 33568403 PMC7985430
- [5]Samuelsson U, Anderzen J, Åkesson K, Hanberger L. The importance of low HbA1c during childhood on glycaemic control in adulthood and the risk of late complications. Acta Paediatr 2021; 110: 1264– 1272 32978990
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Real-world evidence of automated insulin delivery system use
Considine, E. G., & Sherr, J. L. (2024) · Diabetes Technology & Therapeutics · doi:10.1089/dia.2023.0442 · Cited by 59 · see citing works
Clinical utility of the twiist Automated Insulin Delivery System: first study with twiist
Ruiz, A., Mcdonough, A., Snow, K., Bode, B., & Mitri, J. (2026) · BMJ Open Diabetes Research & Care · doi:10.1136/bmjdrc-2026-006307
- Authors
- Tornese, G., Carletti, C., Lanzetta, M. A., Tamaro, G., Barbi, E., & Faleschini, E.
- Affiliations
- IRCCS Materno Infantile Burlo Garofolo (IT)
- University of Trieste (IT)
- Corresponding author
- Tornese, Gianluca
- Venue
- Diabetes Care
- Publisher
- American Diabetes Association
- Published
- 2023-04-17
- Volume
- 46
- Issue
- 6
- Pages
- e123-e125
- ISSN
- 0149-5992 (ISSN-L)
- 1935-5548
- PMC
- PMC10234753
- OpenAlex
- W4366200501
- Cited by
- 29
- References
- 0
- Citations by year
- 2026: 8 · 2025: 7 · 2024: 10 · 2023: 4
- FWCI
- 5.95
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Diabetes Care (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- ArTS Archivio della ricerca di Trieste (University of Trieste https://www.units.it/) (submittedVersion)
- Funders
- Italian Ministry of Health (RC 14/16)
- ISPAD-JDRF (JDRF-ISPAD Fellowship 2017)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Education
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Diabetes and associated disorders
- Keywords
- type 1 diabetes, children, MiniMed 780G, advanced hybrid closed-loop system, insulin pump therapy, real-world safety, glycemic control, insulin dose, carbohydrate intake, device adherence
- MeSH terms
- Blood Glucose, Child, Diabetes Mellitus, Type 1, Humans, Hypoglycemic Agents, Insulin, Insulin Infusion Systems, Blood Glucose Self-Monitoring
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