Glycemic Variability: Both Sides of the Story
Open accessAbstract
Case for a relationship between postprandial hyperglycemic variability and complication risk In both type 1 and type 2 diabetes, large prospective clinical studies have shown a strong relationship between time-averaged mean levels of glycemia as measured by HbA1c and diabetes complications (1). However, as reviewed elsewhere, in recent years several pieces of evidence have raised the possibility that glycemic instability may also contribute to the development of diabetes complications (2). Also reviewed elsewhere, in individ-uals with impaired glucose tolerance the
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Fluctuations in blood glucose levels may contribute more to outcomes than constant high blood glucose concentrations.
“Other studies have demonstrated that fluctuations in blood glucose levels may contribute more to outcomes than constant high blood glucose concentrations.31–35”
From Increased Time in Range and Fewer Missed Bolus Injections After Introduction of a Smart Connected Insulin Pen (2020) · cites this paper as [34]
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References 33 · Cited by 111
- Authors
- Ceriello, A., & Kilpatrick, E. S.
- Affiliations
- Centro de Investigación Biomédica en Red Diabetes y Enfermedades Metabólicas Asociadas (ES)
- Hull Royal Infirmary (GB)
- Corresponding author
- Ceriello, Antonio
- Kilpatrick, Eric S.
- Venue
- Diabetes Care
- Publisher
- American Diabetes Association
- Published
- 2013-07-17
- Volume
- 36
- Issue
- Supplement_2
- Pages
- S272-S275
- ISSN
- 0149-5992 (ISSN-L)
- 1935-5548
- PMC
- PMC3920802
- OpenAlex
- W2110660701
- Cited by
- 111
- References
- 33
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 9 · 2023: 8 · 2022: 9 · 2021: 8 · 2020: 14 · 2019: 12 · 2018: 5 · 2017: 13 · 2016: 13 · 2015: 7 · 2014: 7
- FWCI
- 7.08
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Diabetes Care (publishedVersion)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Keywords
- glycemic variability, postprandial hyperglycemia, diabetes complications, HbA1c, type 1 diabetes, type 2 diabetes, impaired glucose tolerance, glycemic control
- MeSH terms
- Blood Glucose, Cardiovascular Diseases, Humans, Hyperglycemia, Prognosis, Risk Factors, Diabetes Complications
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