Allergic Interstitial Pancreatitis in Rats Injected with Guinea Pig Anti-insulin Serum
Abstract
The diabetic syndrome induced in rats by guinea-pig anti-insulin serum is complicated by interstitial pancreatitis similar in several respects to that seen in some infants born of diabetic mothers. It is characterized by lesions in the exocrine portion of the gland which include eosinophilic infiltration (73 per cent), edema (54 per cent), and focal areas of necrosis (15 per cent) or hemorrhage (14 per cent). Its appearance is not related to the severity of the induced diabetes and its nature suggests that it is allergic in origin. Other histological findings are consistent with previous observations and similar to those encountered in human and other forms of experimental diabetes.
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In animals, injections of anti-insulin serum or homogenized pancreatic or islet tissues resulted in development of islet immune lesions, supporting the idea that islets could generate an immune response.
“In animals, injections of anti-insulin serum, or homogenized pancreatic or islet tissues, resulted in development of islet immune lesions, supporting the idea that islets could generate an immune response34–36.”
From 100 years of insulin: celebrating the past, present and future of diabetes therapy (2021) · cites this paper as [35]
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100 years of insulin: celebrating the past, present and future of diabetes therapy
Sims, E. K., Carr, A. L. J., Oram, R. A., DiMeglio, L. A., & Evans-Molina, C. (2021) · Nature Medicine · doi:10.1038/s41591-021-01418-2 · Cited by 270 · see citing works
- Authors
- Lacy, P. E., & Wright, P. H.
- Affiliations
- Guy's Hospital (GB)
- Venue
- Diabetes
- Publisher
- American Diabetes Association
- Published
- 1965-10-01
- Volume
- 14
- Issue
- 10
- Pages
- 634-642
- ISSN
- 0012-1797 (ISSN-L)
- 1939-327X
- OpenAlex
- W2322195386
- Cited by
- 57
- References
- 0
- Citations by year
- 2021: 1 · 2014: 1
- FWCI
- 4.70
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Diabetes (publishedVersion)
- PubMed (publishedVersion)
- Funders
- U.S. Public Health Service
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Diabetes and associated disorders
- Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
- Health Sciences › Medicine › Surgery › Pancreatitis Pathology and Treatment
- Keywords
- anti-insulin serum, experimental diabetes, eosinophil infiltration, pancreatic necrosis, maternal diabetes, neonatal diabetes, rat model
- MeSH terms
- Animals, Guinea Pigs, Hypersensitivity, Immune Sera, Insulin Antibodies, Kidney, Liver, Pancreatitis, Rats
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