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Cation Requirements for Insulin Secretion in the Isolated Perfused Pancreas
Abstract
The effect of cations on insulin release was studied in the isolated pancreas of the rat perfused with a synthetic perfusate consisting of albumin and buffer. The omission of calcium and magnesium ion completely inhibited insulin release stimulated by glucose. The ionic requirement was specific for calcium ion since perfusates containing calcium but no magnesium permitted normal insulin release by glucose, whereas perfusates containing magnesium but no calcium did not. The presence of only 0.2 mEq. per liter calcium was adequate to permit much, though not all, of the insulin response after glucose to occur. Potassium ion, when raised from 4 to 8 mEq. per liter, directly stimulated insulin release in the complete absence of glucose.
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Citations
Cited by
Triggering and amplifying pathways of regulation of insulin secretion by glucose.
Henquin, J. C. (2000) · Diabetes · doi:10.2337/diabetes.49.11.1751 · Cited by 1,201
Henquin, J. C., & Meissner, H. P. (1984) · Experientia · doi:10.1007/bf01971450 · Cited by 324
Glucoreceptor mechanisms and the control of insulin release and biosynthesis
Ashcroft, S. J. H. (1980) · Diabetologia · doi:10.1007/bf01228295 · Cited by 280
CADE, C., & NORMAN, A. W. (1986) · Endocrinology · doi:10.1210/endo-119-1-84 · Cited by 270
Gustavsson, N., & Han, W. (2009) · Bioscience Reports · doi:10.1042/bsr20090031 · Cited by 91
Metadata
- Authors
- Grodsky, G. M., & Bennett, L. L.
- Venue
- Diabetes
- Publisher
- American Diabetes Association
- Published
- 1966-12-01
- Volume
- 15
- Issue
- 12
- Pages
- 910-910
- ISSN
- 0012-1797 (ISSN-L)
- 1939-327X
- OpenAlex
- W1997432043
- Cited by
- 382
- References
- 0
- FWCI
- 21.43
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Cation Requirements for Insulin Secretion in the Isolated Perfused Pancreas. https://app.cochat.ai/papers/10.2337/diab.15.12.910
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- Grodsky, G. M., & Bennett, L. L. (1966). Cation Requirements for Insulin Secretion in the Isolated Perfused Pancreas. Diabetes. https://doi.org/10.2337/diab.15.12.910
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
