Histocompatibility (HL-A) Antigens, Lymphocytotoxic Antibodies and Tissue Antibodies in Patients with Diabetes Mellitus
Abstract
Diabetes mellitus is a genetically determined disorder of metabolism in which inherited susceptibility plays an important part. We studied the distribution of HL-A antigens, and theincidence of lymphocytotoxic and tissue antibodies in seventy-one adult diabetic patients—fifty insulin-dependent and twenty-one insulin-independent. Specificity W15 was present in significantlyhigher frequency in the insulin-dependent diabetic patients than either in the control group (P = 0.0005) or in the insulin-independent diabetic patient group (P < 0.0005). The incidence of lymphocytotoxic and tissue antibodies in the two patient groups was not different from that in the control population.
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A small number of HLA class 2 alleles explain a large proportion of disease heritability in many autoimmune diseases including type 1 diabetes.
“To this day, a standout feature of many autoimmune diseases including type 1 diabetes is that a small number of HLA class 2 alleles, critical for antigen presentation by the immune system, explain a large proportion of disease heritability.”
From 100 years of insulin: celebrating the past, present and future of diabetes therapy (2021) · cites this paper as [6]
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Cited by 412
- Authors
- Singal, D. P., & Blajchman, M. A.
- Affiliations
- McMaster University (CA)
- Venue
- Diabetes
- Publisher
- American Diabetes Association
- Published
- 1973-06-01
- Volume
- 22
- Issue
- 6
- Pages
- 429-432
- ISSN
- 0012-1797 (ISSN-L)
- 1939-327X
- OpenAlex
- W2116599892
- Cited by
- 412
- References
- 0
- Citations by year
- 2026: 2 · 2025: 8 · 2024: 12 · 2023: 5 · 2022: 9 · 2021: 9 · 2020: 10 · 2019: 5 · 2018: 7 · 2017: 8 · 2016: 8 · 2015: 9 · 2014: 10 · 2013: 10 · 2012: 9
- FWCI
- 10.60
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Diabetes (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Diabetes and associated disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
- Keywords
- histocompatibility antigens, HLA antigens, lymphocytotoxic antibodies, tissue antibodies, diabetes mellitus, type 1 diabetes, insulin-independent diabetes, genetic susceptibility to diabetes
- MeSH terms
- Antibodies, Antibody Formation, Antilymphocyte Serum, Antibodies, Antinuclear, Cytotoxicity Tests, Immunologic, Diabetes Mellitus, Erythrocytes, Female, Genetics, Medical, Hemagglutination Tests, Histocompatibility Antigens, Humans, Insulin, Lymphocytes, Male, Metabolic Diseases, Tannins
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