Islet Cell Changes in the Rat Following Injection of Homogenized Islets
Abstract
The effect of repeated subcutaneous injections of homogenized rat islets on the morphology of the pancreas of the injected animals was determined. Male Wistar rats were injected with fifty homogenized islets every two weeks and were killed in groups of two to three over a twelve-month period beginning two months after the first injection of islets. The chronic injection of islet homogenates produced fibrosis of the islets in the injected animals with marked distortion of the architecture of the islets and the deposition of hemosiderin in the peri-insular tissue. In a few instances, lymphocytic infiltration was observed in the peri-insular area. The cause of this unusual islet lesion was presumably due to an antigen-antibody reaction in the islets. None of the injected animals developed either hyperglycemia or glycosuria.
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In animals, injections of anti-insulin serum or homogenized pancreatic or islet tissues resulted in development of islet immune lesions, supporting the idea that islets could generate an immune response.
“In animals, injections of anti-insulin serum, or homogenized pancreatic or islet tissues, resulted in development of islet immune lesions, supporting the idea that islets could generate an immune response34–36.”
From 100 years of insulin: celebrating the past, present and future of diabetes therapy (2021) · cites this paper as [36]
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100 years of insulin: celebrating the past, present and future of diabetes therapy
Sims, E. K., Carr, A. L. J., Oram, R. A., DiMeglio, L. A., & Evans-Molina, C. (2021) · Nature Medicine · doi:10.1038/s41591-021-01418-2 · Cited by 270 · see citing works
- Authors
- Heydinger, D. K., & Lacy, P. E.
- Affiliations
- Riverside Methodist Hospital (US)
- Washington University in St. Louis (US)
- Venue
- Diabetes
- Publisher
- American Diabetes Association
- Published
- 1974-07-01
- Volume
- 23
- Issue
- 7
- Pages
- 579-582
- ISSN
- 0012-1797 (ISSN-L)
- 1939-327X
- OpenAlex
- W2322232430
- Cited by
- 18
- References
- 0
- Citations by year
- 2021: 1 · 2020: 2
- FWCI
- 2.33
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Diabetes (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Diabetes and associated disorders
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
- Keywords
- islet fibrosis, islet morphology, hemosiderin deposition, antigen-antibody reaction, hyperglycemia, glycosuria, rat pancreas
- MeSH terms
- Animals, Antigen-Antibody Reactions, Blood Glucose, Connective Tissue, Glycosuria, Hemosiderin, Injections, Subcutaneous, Islets of Langerhans, Lymphocytes, Male, Rats
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