Maintenance of Basal Plasma Glucose and Insulin Concentrations in Maturity-Onset Diabetes
Abstract
Normal and mildly diabetic subjects each have their own "set" of basal plasma glucose and insulin concentrations. Diabetic patients have raised basal plasma glucose, with low-normal basal plasma C-peptide concentrations. Restoring normal glucose levels in mild diabetes by an insulin infusion further reduces the C-peptide concentration, but both the plasma glucose and the C-peptide return to their "set" level when the insulin is withdrawn. These results accord with the action of beta cells and liver in a negative feedback loop that maintains basal plasma glucose and insulin concentrations.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Fasting plasma glucose and insulin concentrations in each normal subject or Type 2 diabetic patient are set at a level characteristic for that individual for a given state of nutrition.
“The fasting plasma glucose and insulin concentrations in each normal subject or Type 2 (non-insulin-dependent) diabetic patient are set at a level characteristic for that individual for a given state of nutrition [1,2].”
From Homeostasis model assessment: insulin resistance and ?-cell function from fasting plasma glucose and insulin concentrations in man (1985) · cites this paper as [1]
Basal hyperglycaemia in diabetes arises from the feedback loop between the liver and beta-cells, maintaining effective insulin action in the liver and periphery.
“the basal hyperglycaemia in diabetes appears to arise from the feedback loop between the liver and/3-cells, thereby maintaining an effective insulin action in the liver and at the periphery [1,4].”
From Homeostasis model assessment: insulin resistance and ?-cell function from fasting plasma glucose and insulin concentrations in man (1985) · cites this paper as [1]
The citation lists haven’t been fetched yet
Cited by 62
- Authors
- Holman, R. R., & Turner, R. C.
- Affiliations
- John Radcliffe Hospital (GB)
- ORCID
- Holman, R R
- Venue
- Diabetes
- Publisher
- American Diabetes Association
- Published
- 1979-03-01
- Volume
- 28
- Issue
- 3
- Pages
- 227-230
- ISSN
- 0012-1797 (ISSN-L)
- 1939-327X
- OpenAlex
- W2148654989
- Cited by
- 62
- References
- 0
- Citations by year
- 2025: 2 · 2024: 1 · 2019: 1 · 2018: 1 · 2015: 2 · 2014: 2
- FWCI
- 6.64
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Diabetes (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
- Keywords
- maturity-onset diabetes, basal insulin, C-peptide, insulin infusion, negative feedback loop, pancreatic beta cells, glucose homeostasis, insulin withdrawal
- MeSH terms
- Adult, Blood Glucose, C-Peptide, Diabetes Mellitus, Humans, Insulin, Middle Aged
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
