Correlation between the nature and amount of carbohydrate in meal intake and insulin delivery by the artificial pancreas in 24 insulin-dependent diabetics
Abstract
We have studied the effects of mixed meals and dextrose intake on blood glucose and insulin delivery by the artificial pancreas in 24 insulin-dependent diabetics. A group of 12 patients had 3 mixed meals containing at random 20, 40, and 60 g of complex carbohydrate along with protein and fat; another group of 12 diabetics, comparable in weight, age, and duration of diabetes, received at random 20, 40, and 60 g of dextrose. Dextrose ingestion led to a higher initial blood glucose increase than did the mixed meal, but the duration of blood glucose increase lasted significantly longer after the mixed meal than after the dextrose load. The areas under the curves of hyperglycemia were not significantly different. There was a high (but not linear) correlation between the total amount of insulin delivered in order to restore initial blood glucose values and the amount of CHO consumed. There was no correlation with age, body weight, duration of diabetes, nor with the nature and order of administration of the CHO load; 5.1 ± 1.6 to 13.7 ± 2.1 units of insulin were needed for a period of 94 ± 11 to 132 ± 11 min. It is suggested that some of the data obtained in this study might be useful in the programming of an open-loop insulin infusion system.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Some but not all studies that used the Biostator controlled for physical activity levels, meal sizes, composition, and calorie content varied from meal to meal in all but one.
“Although some (20,24,27) but not all (21–23,26) studies that used the Biostator controlled for physical activity levels, meal sizes, composition, and calorie content varied from meal to meal in all but one (27).”
From Diurnal Pattern of Insulin Action in Type 1 Diabetes (2013) · cites this paper as [22]
Multiple investigators have reported correlations among total carbohydrate ingested, postprandial glucose excursions, and insulin administered when using the Biostator.
“However, multiple investigators have reported correlations among the total amount of carbohydrate ingested, postprandial glucose excursions, and insulin administered when using the Biostator (21–23).”
From Diurnal Pattern of Insulin Action in Type 1 Diabetes (2013) · cites this paper as [22]
The citation lists haven’t been fetched yet
References 11 · Cited by 66
- Authors
- Slama, G., Klein, J.-C., Delage, A., Ardila, E., Lemaignen, H., Papoz, L., & Tchobroutsky, G.
- Affiliations
- Inserm (FR)
- Centre de Morphologie Mathématique - CMM (FR)
- ORCID
- Ardila, Enrique
- Venue
- Diabetes
- Publisher
- American Diabetes Association
- Published
- 1981-02-01
- Volume
- 30
- Issue
- 2
- Pages
- 101-105
- ISSN
- 0012-1797 (ISSN-L)
- 1939-327X
- OpenAlex
- W1965781453
- Cited by
- 66
- References
- 11
- Citations by year
- 2025: 1 · 2021: 2 · 2020: 1 · 2019: 1 · 2018: 1 · 2017: 1 · 2016: 3 · 2015: 3 · 2013: 2 · 2012: 3
- FWCI
- 2.13
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Diabetes (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
- Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Education
- Keywords
- insulin pump therapy, artificial pancreas, type 1 diabetes, carbohydrate intake, mixed meal, glycemic response, insulin delivery, hyperglycemia
- MeSH terms
- Adult, Artificial Organs, Blood Glucose, Diabetes Mellitus, Dietary Carbohydrates, Female, Glucose, Humans, Insulin, Male, Pancreas
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
