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Reduced Sulfation of Liver Heparan Sulfate in Experimentally Diabetic Rats
Abstract
Analyses by anion exchange chromatography indicate that heparan sulfate proteoglycans isolated from the livers of experimentally diabetic rats have a reduced net negative charge as compared with heparan sulfate proteoglycans from control rats. In contrast, the size of the normal and diabetic proteoglycans are indistinguishable as are the size of individual polysaccharide chains when compared by gel chromatography. The reduced net negative charge of heparin sulfate from diabetic rats is shown to be caused by a reduced number of sulfate groups present in the diabetic heparan sulfate. Results are presented suggesting that one of the biosynthetic enzymes; the N-deacelylase, which tentatively has been identified as a regulatory enzyme affecting the sulfate content of the polysaccharide chains, may be inhibited in the diabetic rat.
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“Interestingly, livers from insulin-deficient rodents show reduced HS production (66, 67), reduced sulfation of the chains (68), and decreased expression of Ndst1 (69,70).”
From Liver heparan sulfate proteoglycans mediate clearance of triglyceride-rich lipoproteins independently of LDL receptor family members (2007) · cites this paper as [68]
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Deckert, T., Feldt-Rasmussen, B., Borch-Johnsen, K., Jensen, T., & Kofoed-Enevoldsen, A. (1989) · Diabetologia · doi:10.1007/bf00285287 · Cited by 1,400
MacArthur, J. M., Bishop, J. R., Stanford, K. I., Wang, L., Bensadoun, A., Witztum, J. L., & Esko, J. D. (2007) · Journal of Clinical Investigation · doi:10.1172/jci29154 · Cited by 216
New Insights into the Heparan Sulfate Proteoglycan-binding Activity of Apolipoprotein E
Libeu, C. P., Lund-Katz, S., Phillips, M. C., Wehrli, S., Hernáiz, M. J., Capila, I., Linhardt, R. J., Raffaı̈, R. L., Newhouse, Y. M., Zhou, F., et al. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m104746200 · Cited by 113
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Williams, K. J., & Chen, K. (2010) · Current Opinion in Lipidology · doi:10.1097/mol.0b013e328338cabc · Cited by 91
Metadata
- Authors
- Kjellén, L., Bielefeld, D., & Hook, M.
- Venue
- Diabetes
- Publisher
- American Diabetes Association
- Published
- 1983-04-01
- Volume
- 32
- Issue
- 4
- Pages
- 337-342
- ISSN
- 0012-1797
- 1939-327X
- Cited by
- 67
- References
- 0
- Language
- en
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