Cited by 753Diabetes Management and ResearchDiabetes, Cardiovascular Risks, and LipoproteinsPancreatic function and diabetes

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Measurement of Plasma Glucose, Free Fatty Acid, Lactate, and Insulin for 24 h in Patients With NIDDM

Reaven, Gerald M, Hollenbeck, Clarie, Jeng, Chii-Yang, Wu, Min Shung, Chen, Yii-Der Ida·1988·Diabetes

DOI 10.2337/diab.37.8.1020

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Abstract

Fasting and postprandial plasma glucose, free fatty acid (FFA), lactate, and insulin concentrations were measured at hourly intervals for 24 h in 27 nonobese individuals—9 with normal glucose tolerance, 9 with mild non-insulin-dependent diabetes mellitus (NIDDM, fasting plasma glucose < 175 mg/dl), and 9 with severe NIDDM (fasting plasma glucose > 250 mg/dl). In addition, hepatic glucose production (HGP) was measured from midnight to 0800 in normal individuals and patients with severe NIDDM. Plasma glucose concentration was highest in patients with severe NIDDM, lowest in those with normal glucose tolerance, and intermediate in those with mild NIDDM (two-way ANOVA, P < .001). Variations in plasma FFA and lactate levels of the three groups were qualitatively similar, with lowest concentrations seen in normal individuals, intermediate levels in the group with mild NIDDM, and the highest concentration in those with severe NIDDM (two-way ANOVA, P < .001). Of particular interest was the observation that plasma FFA concentrations were dramatically elevated from midnight to 0800 in patients with severe NIDDM. The 24-h insulin response was significantly increased in patients with mild NIDDM, with comparable values seen in the other two groups. Values for HGP fell progressively throughout the night in normal individuals and patients with severe NIDDM, despite a concomitant decline in plasma glucose and insulin levels. Although the magnitude of the fall in HGP was greater in NIDDM, the absolute value was significantly (P < .001) greater than normal throughout the period of observation. These results demonstrate that there are differences in substrate level between individuals with normal glucose tolerance and patients with NIDDM and differing degrees of glucose intolerance, unrelated to ambient insulin level, and these changes persist over 24 h.

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Self-citation
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Østergård, T., Jessen, N., Schmitz, O., & Mandarino, L. J. (2007) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/h07-031 · Cited by 36
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Py, G., Lambert, K., Pérez‐Martin, A., de Mauverger, É. R., PREFAUT, C. G., & Mercier, J. G. (2001) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.2001.281.6.e1308 · Cited by 36
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Kokorovic, A., Cheung, G. W. C., Rossetti, L., & Lam, T. K. T. (2008) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2008.00596.x · Cited by 36
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Esteves, J. V. D. C., & Stanford, K. I. (2024) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00144.2024 · Cited by 39
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Ishida, T., Naoe, S., Nakakuki, M., Kawano, H., & Imada, K. (2015) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat.28167 · Cited by 33
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Song, H., Wohltmann, M., Tan, M., Ladenson, J. H., & TURK, J. W. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.561910 · Cited by 35
Adiposity in children born small for gestational age
Tappy, L. (2006) · International Journal of Obesity · doi:10.1038/sj.ijo.0803517 · Cited by 33
Relation between insulinemia, body mass index, and lipoprotein composition in healthy, nondiabetic men and women.
Winocour, P. H., Kaluvya, S., Ramaiya, K. L., Brown, L., Millar, J. P., Farrer, M., Neil, H. A. W., Laker, M. F., & Alberti, K. G. M. M. (1992) · Arteriosclerosis and Thrombosis A Journal of Vascular Biology · doi:10.1161/01.atv.12.3.393 · Cited by 33
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Rodrı́guez-Lee, M., Östergren‐Lundén, G., Wallin, B., Moses, J., Bondjers, G., & Camejo, G. (2005) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000191659.94059.62 · Cited by 33
Does Glucagon-like Peptide-1 Ameliorate Oxidative Stress in Diabetes? Evidence Based on Experimental and Clinical Studies
Petersen, K. E., Rakipovski, G., Raun, K., & Lykkesfeldt, J. (2016) · Current Diabetes Reviews · doi:10.2174/1573399812666150918150608 · Cited by 35
Desequilíbrio autonômico e síndrome metabólica: parceiros patológicos em uma pandemia global emergente
Lopes, H. F., & Egan, B. M. (2006) · Arquivos Brasileiros de Cardiologia · doi:10.1590/s0066-782x2006001700022 · Cited by 33
Effect of Progressive Weight Loss on Lactate Metabolism: A Randomized Controlled Trial
Chondronikola, M., Magkos, F., Yoshino, J., Okunade, A. L., Patterson, B. W., Muehlbauer, M. J., Newgard, C. B., & Klein, S. (2018) · Obesity · doi:10.1002/oby.22129 · Cited by 31
Molecular signaling mechanisms of renal gluconeogenesis in nondiabetic and diabetic conditions
Swe, M. T., Pongchaidecha, A., Chatsudthipong, V., Chattipakorn, N., & Lungkaphin, A. (2018) · Journal of Cellular Physiology · doi:10.1002/jcp.27598 · Cited by 31
Palmitate induces apoptosis in Schwann cells via both ceramide-dependent and independent pathways
Suzuki, J., Akahane, K., Nakamura, J., Naruse, K., Kamiya, H., Himeno, T., Nakamura, N., Shibata, T., Kondo, M., Nagasaki, H., et al. (2010) · Neuroscience · doi:10.1016/j.neuroscience.2010.11.035 · Cited by 31
Electroacupuncture and Rosiglitazone Combined Therapy as a Means of Treating Insulin Resistance and Type 2 Diabetes Mellitus: A Randomized Controlled Trial
Lin, R.-T., Pai, H.-C., Lee, Y., Tzeng, C., Chang, C.-H., Hung, P., Chen, Y., Hsu, T., Tsai, C.-C., Lin, J., et al. (2013) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2013/969824 · Cited by 30
Self-citation
Gliclazide modified release: From once-daily administration to 24-hour blood glucose control
Harrower, A. (2000) · Metabolism · doi:10.1053/meta.2000.17823 · Cited by 30
Multifaceted effects of obesity on cancer immunotherapies: Bridging preclinical models and clinical data
Vick, L. V., Canter, R. J., Monjazeb, A. M., & Murphy, W. J. (2023) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2023.07.004 · Cited by 35
Bioinformatics Methodologies to Identify Interactions Between Type 2 Diabetes and Neurological Comorbidities
Rahman, M. H., Peng, S., Hu, X., Chen, C., Uddin, S., Quinn, J. M. W., & Moni, M. A. (2019) · IEEE Access · doi:10.1109/access.2019.2960037 · Cited by 30
Current Views of the Fat Cell as an Endocrine Cell: Lipotoxicity
Tchkonia, T., Corkey, B. E., & Kirkland, J. L. (2007) · Springer eBooks · doi:10.1007/978-0-387-32164-6_6 · Cited by 31

Authors: Reaven, G. M., Hollenbeck, C., Jeng, C.-Y., Wu, M. S., & Chen, Y.-D. I.
Affiliations: VA Palo Alto Health Care System (US)
ORCID: Chen, Yii-Der Ida
Venue: Diabetes
Publisher: American Diabetes Association
Published: 1988-08-01
Volume: 37
Issue: 8
Pages: 1020-1024
ISSN: 0012-1797 (ISSN-L)
1939-327X
DOI: 10.2337/diab.37.8.1020
OpenAlex: W2109820048
Cited by: 753
References: 0
Citations by year: 2026: 3 · 2025: 6 · 2024: 13 · 2023: 13 · 2022: 6 · 2021: 21 · 2020: 27 · 2019: 22 · 2018: 25 · 2017: 32 · 2016: 27 · 2015: 28 · 2014: 37 · 2013: 34 · 2012: 27
FWCI: 4.05
Type: journal article
Language: en
Open access: closed
Locations: Diabetes (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health
National Institute of Diabetes and Digestive and Kidney Diseases (DK30732)
National Center for Research Resources (RR-00070-26)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pancreatic function and diabetes
Keywords: type 2 diabetes, plasma glucose, free fatty acids, lactate, insulin response, hepatic glucose production, circadian variation, fasting blood glucose, postprandial blood glucose, glucose tolerance
MeSH terms: Blood Glucose, Circadian Rhythm, Diabetes Mellitus, Type 2, Fatty Acids, Nonesterified, Humans, Insulin, Lactates, Monitoring, Physiologic, Time Factors

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Measurement of Plasma Glucose, Free Fatty Acid, Lactate, and Insulin for 24 h in Patients With NIDDM

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