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Pancreatic beta-cell glucokinase: closing the gap between theoretical concepts and experimental realities.
Abstract
There remains a wide gap between theoretical concepts and experimental realities in the enzyme kinetics and biochemical genetics of the pancreatic beta-cell glucokinase-glucose sensor. It is the goal of present efforts in many laboratories to bridge this gap. This perspective intends to provide a timely review of this crucial aspect of research in glucose homeostasis. It deals briefly with some fundamentals of glucokinase enzyme kinetics, offers some pertinent biochemical genetic considerations, takes stock of the current experimental database of the field by emphasizing human studies and referring to recent mouse studies, and ventures a few extrapolations into the future of this endeavor.
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Cited by
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Evans, J. L., Goldfine, I. D., Maddux, B. A., & Grodsky, G. M. (2002) · Endocrine Reviews · doi:10.1210/er.2001-0039 · Cited by 2,232
Molecular mechanisms and clinical pathophysiology of maturity-onset diabetes of the young
Fajans, S. S., Bell, G. I., & Polonsky, K. S. (2001) · New England Journal of Medicine · doi:10.1056/nejmra002168 · Cited by 1,123
Zhang, C.-Y., Baffy, G., Perret, P., Krauss, S., Peroni, O., Grujic, D., Hagen, T., Vidal-Puig, A. J., Boss, O., Kim, Y.-B., et al. (2001) · Cell · doi:10.1016/s0092-8674(01)00378-6 · Cited by 917
Insulin Production by Human Embryonic Stem Cells
Assady, S., Maor, G., Amit, M., Itskovitz-Eldor, J., Skorecki, K. L., & Tzukerman, M. (2001) · Diabetes · doi:10.2337/diabetes.50.8.1691 · Cited by 905
Sivitz, W. I., & Yorek, M. A. (2010) · Antioxidants & Redox Signaling · doi:10.1089/ars.2009.2531 · Cited by 742
Metadata
- Authors
- Matschinsky, F. M., Glaser, B., & Magnuson, M. A.
- Venue
- Diabetes
- Publisher
- American Diabetes Association
- Published
- 1998-03-01
- Volume
- 47
- Issue
- 3
- Pages
- 307-315
- ISSN
- 0012-1797 (ISSN-L)
- 1939-327X
- OpenAlex
- W2050051162
- Cited by
- 333
- References
- 0
- FWCI
- 19.61
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Pancreatic beta-cell glucokinase: closing the gap between theoretical concepts and experimental realities. https://app.cochat.ai/papers/10.2337/diabetes.47.3.307
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- Matschinsky, F. M., Glaser, B., & Magnuson, M. A. (1998). Pancreatic beta-cell glucokinase: closing the gap between theoretical concepts and experimental realities. Diabetes. https://doi.org/10.2337/diabetes.47.3.307
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
