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Cited by 243Diabetes, Cardiovascular Risks, and LipoproteinsObesity, Physical Activity, DietAdipokines, Inflammation, and Metabolic Diseases

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Phenotypic characteristics associated with insulin resistance in metabolically obese but normal-weight young women.

Dvorak, R V, DeNino, W F, Ades, P A, Poehlman, E T·1999·Diabetes
DOI 10.2337/diabetes.48.11.2210
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Abstract

Metabolically obese, normal-weight (MONW) individuals are a hypothesized subgroup of the general population. These normal-weight individuals potentially display a cluster of obesity-related features, although this has not been systematically tested in young women. We hypothesized that MONW young women would display higher levels of total and visceral fat and lower levels of physical activity than normal women. In a cohort of 71 healthy nonobese women (21-35 years old), we identified MONW women based on cut points for insulin sensitivity (normal = glucose disposal >8 mg x min(-1) x kg(-1) of fat-free mass [FFM], n = 58; impaired = glucose disposal <8 ml x min(-1) x kg(-1) of FFM, n = 13). Thereafter, we measured body composition (dual energy X-ray absorptiometry) and body fat distribution (computed tomography), cardiorespiratory fitness (VO2max on a treadmill), physical activity energy expenditure (doubly labeled water and indirect calorimetry), glucose tolerance (oral glucose tolerance test), serum lipid profile, and dietary intake. We found a higher body fat percentage (32 +/- 6 vs. 27 +/- 6%, P = 0.01) and higher subcutaneous (213 +/- 61 vs. 160 +/- 78 cm2, P = 0.03) and visceral (44 +/- 16 vs. 35 +/- 14 cm2, P < 0.05) abdominal adiposity in the MONW group versus the normal group. The MONW group showed a lower physical activity energy expenditure (2.66 +/- 0.92 vs. 4.39 +/- 1.50 MJ/day, P = 0.01), but no difference in cardiorespiratory fitness was noted between groups. In conclusion, despite a normal body weight, a subset of young, apparently healthy women displayed a cluster of risky phenotypic characteristics that, if left untreated, may eventually predispose them to type 2 diabetes and cardiovascular disease.

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Metadata

Authors
Dvorak, R. V., DeNino, W. F., Ades, P. A., & Poehlman, E. T.
Affiliations
  • Department of Medicine, College of Medicine, University of Vermont, Burlington 05405, USA.
  • University of Vermont (US)
Venue
Diabetes
Publisher
American Diabetes Association
Published
1999-11-01
Volume
48
Issue
11
Pages
2210-2214
ISSN
  • 0012-1797 (ISSN-L)
  • 1939-327X
DOI
10.2337/diabetes.48.11.2210
OpenAlex
W2155025864
Cited by
243
References
0
Citations by year
2026: 2 · 2025: 1 · 2024: 4 · 2023: 6 · 2022: 9 · 2021: 7 · 2020: 4 · 2019: 10 · 2018: 15 · 2017: 8 · 2016: 16 · 2015: 11 · 2014: 12 · 2013: 12 · 2012: 17
FWCI
3.86
Type
journal article
Language
en
Open access
closed
Locations
  • Diabetes (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (5r01ag015114-03)
  • National Institute on Aging (R01-AG15114)
  • National Institute of Dental and Craniofacial Research (DE 950226)
  • National Center for Research Resources (RR-00109)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Obesity, Physical Activity, Diet
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Keywords
insulin resistance, visceral fat, subcutaneous abdominal fat, physical activity energy expenditure, cardiorespiratory fitness, body composition, glucose tolerance, type 2 diabetes risk, cardiovascular risk, young women
MeSH terms
Adipose Tissue, Adult, Blood Glucose, Blood Pressure, Body Constitution, Body Weight, Contraceptives, Oral, Diabetes Mellitus, Female, Glucose, Humans, Obesity, Phenotype, Reference Values, Body Mass Index

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