The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.
beta-cell turnover: its assessment and implications.
Open accessAbstract
The pancreatic beta-cells are responsible for the maintenance of the body's glucose levels within a very narrow range; their population is dynamic and undergoes compensatory changes to maintain euglycemia. The structural parameters that allow mass changes (replication, neogenesis, cell volume changes, and cell death) can now be assessed and have proved to be powerful tools. Changes in one parameter can dramatically affect the beta-cell mass. Unfortunately, conclusions are often drawn on measurements that do not assess beta-cell mass but only relative volumes. Throughout the lifetime of a mammal, low levels of beta-cell replication and apoptosis are balanced and result in a slowly increasing mass. The balance allows gradual replacement of the beta-cell population; thus, beta-cells should be considered a slowly renewed tissue. Two major implications of beta-cell turnover are that 1) at any time, the beta-cells would be at different ages and 2) any limitation on replacement could have dire consequences for glucose homeostasis.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“β-Cell mass can slowly expand in adult rodents in response to increased insulin requirements (3) or during pregnancy (4).”
From Adaptive β-Cell Proliferation Is Severely Restricted With Advanced Age (2009) · cites this paper as [3]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Induction of apoptosis in fibroblasts by c-myc protein
Evan, G. I., Wyllie, A. H., Gilbert, C. S., Littlewood, T. D., Land, H., Brooks, M. W., Waters, C. M., Penn, L. Z., & Hancock, D. C. (1992) · Cell · doi:10.1016/0092-8674(92)90123-t · Cited by 2,941
Disruption of IRS-2 causes type 2 diabetes in mice
Withers, D. J., Gutierrez, J. S., Towery, H. H., Burks, D. J., Ren, J., Previs, S. F., Zhang, Y., Bernal, D., Pons, S., Shulman, G. I., et al. (1998) · Nature · doi:10.1038/36116 · Cited by 1,775
Self-citationBonner‐Weir, S., Baxter, L. A., Schuppin, G. T., & Smith, F. E. (1993) · Diabetes · doi:10.2337/diab.42.12.1715 · Cited by 675
Self-citationIslet pathology and the pathogenesis of type 1 and type 2 diabetes mellitus revisited.
Klöppel, G., Löhr, M., Habich, K., Oberholzer, M., & Heitz, P. (1985) · Survey and Synthesis of Pathology Research · doi:10.1159/000156969 · Cited by 645
Development of a Novel Polygenic Model of NIDDM in Mice Heterozygous for IR and IRS-1 Null Alleles
Brüning, J. C., Winnay, J. N., Bonner‐Weir, S., Taylor, S. I., Accili, D., & Kahn, C. R. (1997) · Cell · doi:10.1016/s0092-8674(00)81896-6 · Cited by 539
Self-citationApoptosis Participates in the Remodeling of the Endocrine Pancreas in the Neonatal Rat
Scaglia, L., Cahill, C. J., Finegood, D. T., & Bonner‐Weir, S. (1997) · Endocrinology · doi:10.1210/endo.138.4.5069 · Cited by 418
Self-citationIslet growth and development in the adult
Bonner‐Weir, S. (2000) · Journal of Molecular Endocrinology · doi:10.1677/jme.0.0240297 · Cited by 332
Self-citationSharma, A., Zangen, D., Reitz, P., Taneja, M., Lissauer, M. E., Miller, C. P., Weir, G. C., Habener, J. F., & Bonner‐Weir, S. (1999) · Diabetes · doi:10.2337/diabetes.48.3.507 · Cited by 331
Self-citationMonoclonal Antibody to Single-Stranded DNA Is a Specific and Sensitive Cellular Marker of Apoptosis
Frankfurt, O. S., Robb, J. A., Sugarbaker, E. V., & Villa, L. (1996) · Experimental Cell Research · doi:10.1006/excr.1996.0240 · Cited by 244
Extra-insular beta cells associated with ductules are frequent in adult human pancreas
Bouwens, L., & PIPELEERS, D. G. (1998) · Diabetologia · doi:10.1007/s001250050960 · Cited by 229
Petrik, J., Arany, E. J., McDonald, T. J., & Hill, D. J. (1998) · Endocrinology · doi:10.1210/endo.139.6.6042 · Cited by 211
Bonner-Weir, S., Baxter, L. A., Schuppin, G. T., et al. (1993) · Diabetes · doi:10.2337/diabetes.42.12.1715 · Cited by 195
Self-citationProliferation and differentiation in the human fetal endocrine pancreas
Bouwens, L., Lu, W., & de Krijger, R. R. (1997) · Diabetologia · doi:10.1007/s001250050693 · Cited by 183
Parsons, J. A., Bartke, A., & Sorenson, R. L. (1995) · Endocrinology · doi:10.1210/en.136.5.2013 · Cited by 152
Wang, R. N., Bouwens, L., & Kl�ppel, G. (1994) · Diabetologia · doi:10.1007/bf00418372 · Cited by 150
Effects of Aging on the Regenerative Capacity of the Pancreatic B-Cell of the Rat
Swenne, I. (1983) · Diabetes · doi:10.2337/diab.32.1.14 · Cited by 147
Parsons, J. A., Bartke, A., & Sorenson, R. L. (1995) · Endocrinology · doi:10.1210/endo.136.5.7720649 · Cited by 142
Hill, D. J., Strutt, B. J., Arany, E. J., Zaina, S., Coukell, S., & Graham, C. F. (2000) · Endocrinology · doi:10.1210/endo.141.3.7354 · Cited by 77
Blume, N., Skouv, J., Larsson, L., Holst, J. J., & Madsen, O. D. (1995) · Journal of Clinical Investigation · doi:10.1172/jci118278 · Cited by 75
Islet Cell Replication and Diabetes
Hellerström, C., Swenne, I., & Andersson, A. (1988) · Springer eBooks · doi:10.1007/978-3-642-72691-0_9 · Cited by 68
The Pathology of the Endocrine Pancreas in Diabetes
Lefèbvre, P. J., & PIPELEERS, D. G. (1988) · Springer eBooks · doi:10.1007/978-3-642-72691-0 · Cited by 68
Walker, N. I., Winterford, C. M., & Kerr, J. F. R. (1992) · Pancreas · doi:10.1097/00006676-199207000-00002 · Cited by 68
The endocrine pancreas during pregnancy and lactation in the rat.
Marynissen, G., Aerts, L., & Assche, F. A. V. (1983) · PubMed · Cited by 61
Effects of aging on the regenerative capacity of the pancreatic B-cell of the rat
Swenne, I. (1983) · Diabetes · doi:10.2337/diabetes.32.1.14 · Cited by 61
Mundle, S. D., Gao, X. Z., Khan, S., Gregory, S. A., Preisler, H. D., & Raza, A. (1995) · PubMed · Cited by 59
Hogg, J., Hill, D. J., & Han, V. K. M. (1994) · Journal of Molecular Endocrinology · doi:10.1677/jme.0.0130049 · Cited by 53
Molecular mechanisms of renal hypertrophy: Role of p27Kip1
Wolf, G. (1999) · Kidney International · doi:10.1046/j.1523-1755.1999.00695.x · Cited by 40
Gross, D. J., Leibowitz, G., Cerasi, E., & Kaiser, Ν. (1996) · Endocrinology · doi:10.1210/endo.137.12.8940391 · Cited by 35
Wang, R. N., Bouwens, L., & Kl�ppel, G. (1994) · Diabetologia · doi:10.1007/s001250050221 · Cited by 27
Pancreatic Growth and Regeneration
Sarvetnick, N. (1998) · KARGER eBooks · doi:10.1159/isbn.978-3-8055-6618-6 · Cited by 23
Cited by
Sorted by citations
The Physiology of Glucagon-like Peptide 1
Holst, J. J. (2007) · Physiological Reviews · doi:10.1152/physrev.00034.2006 · Cited by 3,371
Glucagon-like peptide 1 (GLP-1)
Müller, T. D., Finan, B., Bloom, S. R., D'Alessio, D., Drucker, D. J., Flatt, P. R., Fritsche, A., Gribble, F., Grill, H. J., Habener, J. F., et al. (2019) · Molecular Metabolism · doi:10.1016/j.molmet.2019.09.010 · Cited by 1,868
Pathogenesis of type 2 diabetes mellitus
DeFronzo, R. A. (2004) · Medical Clinics of North America · doi:10.1016/j.mcna.2004.04.013 · Cited by 1,342
Ianus, A., Holz, G. G., Theise, N. D., & Hussain, M. A. (2003) · Journal of Clinical Investigation · doi:10.1172/jci16502 · Cited by 773
Regulation of Insulin Synthesis and Secretion and Pancreatic Beta-Cell Dysfunction in Diabetes
Fu, Z., Gilbert, E. R., & Liu, D. (2012) · Current Diabetes Reviews · doi:10.2174/157339913804143225 · Cited by 925
Metadata
- Authors
- Bonner-Weir, S.
- Affiliations
- Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts 02215, USA. susan.bonner-weir@joslin.harvard.edu
- Venue
- Diabetes
- Publisher
- American Diabetes Association
- Published
- 2001-02-01
- Volume
- 50
- Issue
- suppl_1
- Pages
- S20
- ISSN
- 0012-1797 (ISSN-L)
- 1939-327X
- OpenAlex
- W2132667679
- Cited by
- 230
- References
- 26
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 1 · 2023: 1 · 2022: 4 · 2020: 7 · 2019: 5 · 2018: 5 · 2017: 2 · 2016: 6 · 2015: 7 · 2014: 11 · 2013: 7 · 2012: 14
- Type
- conference abstract
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Diabetes (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pancreatic function and diabetes
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Diabetes and associated disorders
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
- Keywords
- beta-cell turnover, beta-cell mass, beta-cell proliferation, beta-cell neogenesis, beta-cell apoptosis, glucose homeostasis, pancreatic islets
- MeSH terms
- Animals, Cell Count, Cell Division, Female, Humans, Insulin Resistance, Islets of Langerhans, Male, Rats, Zucker, Cell Death, Apoptosis, In Situ Nick-End Labeling, Models, Animal, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
