The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Regulation of Dietary Fatty Acid Entrapment in Subcutaneous Adipose Tissue and Skeletal Muscle
Open accessAbstract
Using stable isotopic labeling of dietary fatty acids in conjunction with arteriovenous difference measurements, we have assessed the regulation of lipoprotein lipase-derived fatty acid entrapment in subcutaneous adipose tissue and forearm muscle in healthy subjects in the postprandial state. Eight volunteers fasted overnight and were then given a mixed meal containing [ 1-13C]palmitic acid and [1-13C]oleic acid. At baseline and for 6 h after the meal, blood samples were obtained from an arterialized hand vein and veins draining subcutaneous abdominal adipose tissue and forearm muscle, and arteriovenous differences were calculated. Entrapment of labeled fatty acids released by circulating triacylglycerol hydrolysis was close to 100% at 60 min, decreasing to 10–30% by 360 min. Entrapment of labeled fatty acids in forearm muscle was >100% and did not change with time. This study shows that entrapment of dietary fatty acids in adipose tissue in the postprandial period is a highly regulated process (varying with time) and that this can be studied in humans using stable isotope- labeled fatty acids in combination with measurement of appropriate arteriovenous differences. Also, fatty acid trapping in skeletal muscle is fundamentally different from that in adipose tissue, in that all the fatty acids released by lipoprotein lipase in skeletal muscle are taken up by the tissue.
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Frayn, K. N., Shadid, S., Hamlani, R., Humphreys, S. M., Clark, M. L., Fielding, B. A., Boland, O., & Coppack, S. W. (1994) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1994.266.3.e308 · Cited by 188
Self-citationFrayn, K. N., Coppack, S. W., Fielding, B. A., & Humphreys, S. M. (1995) · Advances in Enzyme Regulation · doi:10.1016/0065-2571(94)00011-q · Cited by 175
Self-citationPeripheral triacylglycerol extraction in the fasting and post-prandial states
Potts, J. L., Fisher, R. M., Humphreys, S. M., Coppack, S. W., Gibbons, G. F., & Frayn, K. N. (1991) · Clinical Science · doi:10.1042/cs0810621 · Cited by 84
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Research works printed but not linked: 29
- Sniderman AD: Postprandial hypertriglyceridaemia(s): time to enlarge our pathophysiologic perspective. Eur J Clin Invest 30:935–937,2000 · DOI
- Binnert C, Pachiaudi C, Beylot M, Croset M, Crohen R, Riou J, Laville M: Metabolic fate of an oral long-chain triglyceride load in humans. Am J Physiol 270:E445–E450,1996 · DOI
- Griffiths JA, Humphreys SM, Clark ML, Fielding BA, Frayn KN: Immediate metabolic availability of dietary fat in combination with carbohydrate. Am J Clin Nutr 59:53–59,1994 · DOI
- Fielding BA, Callow J, Owen RM, Samra JS, Matthews DR, Frayn KN: Postprandial lipemia: the origin of an early peak studied by specific dietary fatty acid intake during sequential meals. Am J Clin Nutr 63:36–41,1996 · DOI · Paper page
- Coppack SW, Fisher RM, Gibbons GF, Humphreys SM, McDonough MJ, Potts JL, Frayn KN: Postprandial substrate deposition in human forearm and adipose tissues in vivo. Clin Sci 79:339–348,1990 · DOI · Paper page
- Evans K, Clark ML, Frayn KN: Effects of an oral and intravenous fat load on adipose tissue and forearm lipid metabolism. Am J Physiol 276:E241–E248,1999 · DOI
- Sniderman AD, Cianflone K, Arner P, Summers LKM, Frayn KN: The adipocyte, fatty acid trapping and atherogenesis. Arterioscler Thromb Vasc Biol 18:147–151,1998 · DOI
- Riemens SC, Sluiter WJ, Dullaart RPF: Enhanced escape of non-esterified fatty acids from tissue uptake: its role in impaired insulin-induced lowering of total rate of appearance in obesity and type II diabetes mellitus. Diabetologia 43:416–426,2000 · DOI
- Oakes ND, Thalén PG, Jacinto SM, Ljung B: Thiazolidinediones increase plasma-adipose tissue FFA exchange capacity and enhance insulin-mediated control of systemic FFA availability. Diabetes 50:1158–1165,2001 · DOI · Paper page
- Larsen OA, Lassen NA, Quaade F: Blood flow through human adipose tissue determined with radioactive xenon. Acta Physiol Scand 66:337–345,1966 · DOI · Paper page
- Greenfield ADM, Whitney RJ, Mowbray JF: Methods for the investigation of peripheral blood flow. Br Med Bull 19:101–109,1963 · DOI · Paper page
- Folch J, Lees M, Sloane Stanley G: A simple method for the isolation and purification of total lipids from animal tissues. J Biol Chem 226:497–509,1957 · DOI · Paper page
- Burdge GC, Wright P, Jones AE, Wootton SA: A method for separation of phosphatidylcholine, triacylglycerol, non-esterified fatty acids and cholesterol esters from plasma by solid-phase extraction. Br J Nutr 84:781–787,2000 · DOI · Paper page
- Holland BA, Welch AA, Unwin ID, Buss DH, Paul AA, Southgate DAT: McCance and Widdowson’s The Composition of Foods. 5th ed. Cambridge, U.K., Royal Society of Chemistry and Ministry of Agriculture, Fisheries and Food,1991
- Elia M, Khan K, Calder G, Kurpad A: Glycerol exchange across the forearm assessed by a combination of tracer and arteriovenous exchange techniques. Clin Sci 84:99–104,1993 · DOI
- Frayn KN, Coppack SW, Humphreys SM: Glycerol and lactate uptake in human forearm. Metabolism 40:1317–1319,1991 · DOI
- Halliwell KJ, Fielding BA, Samra JS, Humphreys SM, Frayn KN: Release of individual fatty acids from human adipose tissue in vivo after an overnight fast. J Lipid Res 37:1842–1848,1996 · DOI
- Summers LKM, Barnes SC, Fielding BA, Beysen C, Ilic V, Humphreys SM, Frayn KN: Uptake of individual fatty acids into adipose tissue in relation to their presence in the diet. Am J Clin Nutr 71:1470–1477,2000 · DOI
- Coppack SW, Evans RD, Fisher RM, Frayn KN, Gibbons GF, Humphreys SM, Kirk MJ, Potts JL, Hockaday TDR: Adipose tissue metabolism in obesity: lipase action in vivo before and after a mixed meal. Metabolism 41:264–272,1992 · DOI · Paper page
- Kalant D, Phélis S, Fielding BA, Frayn KN, Cianflone K, Sniderman AD: Increased postprandial fatty acid trapping in subcutaneous adipose tissue in obese women. J Lipid Res 41:1963–1968,2000 · DOI
- Karpe F, Hultin M: Endogenous triglyceride-rich lipoproteins accumulate in rat plasma when competing with a chylomicron-like triglyceride emulsion for a common lipolytic pathway. J Lipid Res 36:1557–1566,1995 · DOI
- van Beek AP, van Barlingen HHJJ, de Ruijter-Heijstek FC, Jansen H, Erkelens DW, Dallinga-Thie GM, de Bruin TWA: Preferential clearance of apoB-48-containing lipoproteins after heparin-induced lipolysis is modulated by lipoprotein lipase activity. J Lipid Res 39:322–332,1998 · DOI
- van der Vusse GJ, Reneman RS: Lipid metabolism in muscle. In: Handbook of Physiology. Section 12. Rowell LB, Shepherd JT, Eds. New York, American Physiological Society,1996, p.952–994 · DOI
- Summers LKM, Fielding BA, Herd SL, Ilic V, Clark ML, Quinlan PT, Frayn KN: Use of structured triacylglycerols containing predominantly stearic and oleic acids to probe early events in metabolic processing of dietary fat. J Lipid Res 40:1890–1898,1999 · DOI
- Lin ECC: Glycerol utilisation and its regulation in mammals. Annu Rev Biochem 46:765–795,1977 · DOI · Paper page
- Kurpad A, Khan K, Calder AG, Coppack S, Frayn K, Macdonald I, Elia M: Effect of noradrenaline on glycerol turnover and lipolysis in the whole body and subcutaneous adipose tissue in humans in vivo. Clin Sci 86:177–184,1994 · DOI
- Coppack SW, Persson M, Judd RL, Miles JM: Glycerol and nonesterified fatty acid metabolism in human muscle and adipose tissue in vivo. Am J Physiol 276:E233–E240,1999 · DOI
- Wolfe RR, Peters EJ: Lipolytic response to glucose infusion in human subjects. Am J Physiol 252:E218–E223,1987 · DOI
- Campbell PJ, Carlson MG, Hill JO, Nurjhan N: Regulation of free fatty acid metabolism by insulin in humans: role of lipolysis and reesterification. Am J Physiol 263:E1063–E1069,1992 · doi:10.1152/ajpendo.1992.263.6.e1063 · Paper page
Cited by
Dyslipidemia in obesity: Mechanisms and potential targets
Klop, B., Elte, J., & Cabezas, M. (2013) · Nutrients · doi:10.3390/nu5041218 · Cited by 1,665
“Despite the uptake of FFA by adipocytes and myocytes, a proportion of FFA remains in the plasma compartment (“spill over”) where the FFA are bound by albumin and transported to the liver [24].”
BackgroundConversion of α -linolenic acid to longer-chain polyunsaturated fatty acids in human adults
Burdge, G. C., & Calder, P. C. (2005) · Reproduction Nutrition Development · doi:10.1051/rnd:2005047 · Cited by 939
Self-citationFatty acids, obesity, and insulin resistance: Time for a reevaluation
Karpe, F., Dickmann, J. R., & Frayn, K. N. (2011) · Diabetes · doi:10.2337/db11-0425 · Cited by 896
Self-citationMetabolism of α-linolenic acid in humans
Burdge, G. C. (2006) · Prostaglandins, Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2006.05.013 · Cited by 388
Self-citationMechanisms for the acute effect of fructose on postprandial lipemia
Chong, M. F.-F., Fielding, B. A., & Frayn, K. N. (2007) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/85.6.1511 · Cited by 368
Self-citation
Metadata
- Authors
- Evans, K., Burdge, G. C., Wootton, S. A., Clark, M. L., & Frayn, K. N.
- Venue
- Diabetes
- Publisher
- American Diabetes Association
- Published
- 2002-09-01
- Volume
- 51
- Issue
- 9
- Pages
- 2684-2690
- ISSN
- 0012-1797 (ISSN-L)
- 1939-327X
- OpenAlex
- W2100003568
- Cited by
- 161
- References
- 3
- FWCI
- 5.19
- Type
- journal article
- Language
- en
- Open access
- bronze
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