Effects of Identical Weight Loss on Body Composition and Features of Insulin Resistance in Obese Women With High and Low Liver Fat Content
Open accessAbstract
Our objective was to determine how 8% weight loss influences subcutaneous, intra-abdominal, and liver fat (LFAT), as well as features of insulin resistance, in obese women with high versus low LFAT. A total of 23 women with previous gestational diabetes were divided into groups of high (9.4 ± 1.4%) and low (3.3 ± 0.4%) LFAT based on their median LFAT (5%) measured with proton spectroscopy. Both groups were similar with respect to age, BMI, and intra-abdominal and subcutaneous fat. Before weight loss, women with high LFAT had higher fasting serum insulin and triglyceride concentrations than women with low LFAT. At baseline, LFAT correlated with the percent of fat (r = 0.44, P < 0.05) and saturated fat (r = 0.45, P < 0.05) of total caloric intake but not intra-abdominal or subcutaneous fat or fasting serum free fatty acids. Weight loss was similar between the groups (high LFAT −7.4 ± 0.2 vs. low LFAT −7.7 ± 0.3 kg). LFAT decreased from 9.4 ± 1.4 to 4.8 ± 0.7% (P < 0.001) in women with high LFAT and from 3.3 ± 0.4 to 2.0 ± 0.2% (P < 0.001) in women with low LFAT. The absolute decrease in LFAT was significantly higher in women with high than low LFAT (−4.6 ± 1.0 vs. −1.3 ± 0.3%, P < 0.005). The decrease in LFAT was closely correlated with baseline LFAT (r = −0.85, P < 0.001) but not with changes in the volumes of intra-abdominal or subcutaneous fat depots, which decreased similarly in both groups. LFAT appears to be related to the amount of fat in the diet rather than the size of endogenous fat depots in obese women. Women with initially high LFAT lost more LFAT by similar weight loss than those with low LFAT, although both groups lost similar amounts of subcutaneous and intra-abdominal fat. These data suggest that LFAT is regulated by factors other than intra-abdominal and subcutaneous fat. Therefore, LFAT does not appear to simply reflect the size of endogenous fat stores.
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Weight loss decreases intrahepatic fat.
“Weight loss decreases visceral fat mass, 26 intramyocellular fat, 27 intrahepatic fat, 28 fat-cell size, 29 and the rate of release of fatty acids from adipose tissue.30”
From Absence of an Effect of Liposuction on Insulin Action and Risk Factors for Coronary Heart Disease (2004) · cites this paper as [28]
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References 57 · Cited by 271
Research works printed but not linked: 1
- [11]11. Sutinen J, Ha ¨kkinen AM, Westerbacka J, Seppa ¨la ¨-Lindroos A, Vehkavaara S, Halavaara J, Ja ¨rvinen A, Ristola M, Yki-Ja ¨rvinen H: Rosiglitatzone in the treatment of HAART-associated lipodystrophy: a randomized placebo- controlled study. Antivir Ther. In press
- Authors
- Tiikkainen, M., Bergholm, R., Vehkavaara, S., Rissanen, A., Häkkinen, A.-M., Tamminen, M., Teramo, K., & Yki-Järvinen, H.
- Affiliations
- University of Helsinki (FI)
- Department of Oncology, University of Helsinki, Helsinki, Finland
- Department of Medicine, Division of Diabetes, University of Helsinki, Helsinki, Finland
- ORCID
- Teramo, Kari
- Venue
- Diabetes
- Publisher
- American Diabetes Association
- Published
- 2003-03-01
- Volume
- 52
- Issue
- 3
- Pages
- 701-707
- ISSN
- 0012-1797 (ISSN-L)
- 1939-327X
- OpenAlex
- W2136587235
- Cited by
- 271
- References
- 57
- Citations by year
- 2026: 3 · 2024: 2 · 2023: 4 · 2022: 4 · 2021: 3 · 2020: 5 · 2019: 6 · 2018: 12 · 2017: 10 · 2016: 9 · 2015: 10 · 2014: 19 · 2013: 10 · 2012: 15
- FWCI
- 11.93
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Diabetes (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Academy of Finland
- Topics
- Health Sciences › Medicine › Epidemiology › Liver Disease Diagnosis and Treatment
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diet, Metabolism, and Disease
- Keywords
- liver fat, hepatic steatosis, weight loss, insulin resistance, obesity, women, gestational diabetes mellitus, subcutaneous adipose tissue, intra-abdominal fat, dietary fat intake, saturated fat, fasting insulin, triglycerides, free fatty acids, 1H NMR, body composition, fat deposition, fat oxidation, fat utilization
- MeSH terms
- Adipose Tissue, Adult, Alanine Transaminase, Blood Pressure, Body Composition, Body Constitution, Female, gamma-Glutamyltransferase, Glycated Hemoglobin, Humans, Insulin, Insulin Resistance, Cholesterol, HDL, Cholesterol, LDL, Liver, Middle Aged, Obesity, Weight Loss, Body Mass Index
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