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A Role for Advanced Glycation End Products in Diminished Bone Healing in Type 1 Diabetes
Open accessAbstract
The effect of type 1 diabetes on bone healing and bone formation in standardized craniotomy defects created in BALB/cByJ mice was determined. The hypothesis that advanced glycation end products (AGEs) contribute to diminished bone healing in diabetes was evaluated by assessing for the presence of the receptor for advanced glycation end products (RAGE) by immunohistochemistry in healing craniotomy defects in diabetic animals. The effect of local application of a known RAGE protein ligand, Nε-(carboxymethyl)lysine (CML)−mouse serum albumin (MSA), on craniotomy defect healing in normal animals was then assessed and compared to the effects of control MSA. Finally, evidence in support of the expression of RAGE mRNA and protein in osteoblastic cells was obtained. The results indicated that craniotomy defects in diabetic animals healed ∼40% of the degree to which they healed in nondiabetic animals (P < 0.05). RAGE was expressed at higher levels in healing bone tissues in diabetic compared to control animals. Further studies in nondiabetic animals indicated that bone healing was reduced by 63 and 42% in lesions treated with 900 and 90 μg CML-MSA, respectively, compared to in animals treated with MSA alone (P < 0.05). Evidence for the expression of RAGE was obtained in mouse and rat osteoblastic cultures. These results support the contribution of AGEs to diminished bone healing in type 1 diabetes, possibly mediated by RAGE.
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Cited by
Advanced glycation endproducts—role in pathology of diabetic complications
Ahmed, N. (2005) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2004.09.004 · Cited by 1,455
Diabetes mellitus and periodontitis: a tale of two common interrelated diseases
Lalla, E., & Papapanou, P. N. (2011) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2011.106 · Cited by 1,048
Diabetes Mellitus and Periodontal Diseases
Mealey, B. L., & Oates, T. W. (2006) · Journal of Periodontology · doi:10.1902/jop.2006.050459 · Cited by 934
Receptor for AGE (RAGE): Signaling mechanisms in the pathogenesis of diabetes and its complications
Ramasamy, R., Yan, S. F., & Schmidt, A. M. (2011) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2011.06320.x · Cited by 521
Diabetes mellitus related bone metabolism and periodontal disease
Wu, Y.-Y., Xiao, E., & Graves, D. T. (2015) · International Journal of Oral Science · doi:10.1038/ijos.2015.2 · Cited by 310
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Metadata
- Authors
- Santana, R. B., Xu, L., Chase, H. B., Amar, S., Graves, D. T., & Trackman, P. C.
- Venue
- Diabetes
- Publisher
- American Diabetes Association
- Published
- 2003-06-01
- Volume
- 52
- Issue
- 6
- Pages
- 1502-1510
- ISSN
- 0012-1797 (ISSN-L)
- 1939-327X
- OpenAlex
- W2114764486
- Cited by
- 251
- References
- 0
- FWCI
- 3.79
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Santana, R. B., Xu, L., Chase, H. B., Amar, S., Graves, D. T., & Trackman, P. C. (2003). A Role for Advanced Glycation End Products in Diminished Bone Healing in Type 1 Diabetes. Diabetes. https://doi.org/10.2337/diabetes.52.6.1502
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