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Cited by 524Metabolism, Diabetes, and CancerMitochondrial Function and PathologyDiabetes Treatment and Management

The DOI matches its Crossref record; 39 of the 39 references it cites were found in a registry or an index.

Thiazolidinediones, Like Metformin, Inhibit Respiratory Complex I

Open access
Brunmair, Barbara, Staniek, Katrin, Gras, Florian, Scharf, Nicole, Althaym, Aleksandra, Clara, Renate, Roden, Michael, Gnaiger, Erich, Nohl, Hans, Waldhäusl, Werner, Fürnsinn, Clemens·2004·Diabetes
DOI 10.2337/diabetes.53.4.1052
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Abstract

Metformin and thiazolidinediones (TZDs) are believed to exert their antidiabetic effects via different mechanisms. As evidence suggests that both impair cell respiration in vitro, this study compared their effects on mitochondrial functions. The activity of complex I of the respiratory chain, which is known to be affected by metformin, was measured in tissue homogenates that contained disrupted mitochondria. In homogenates of skeletal muscle, metformin and TZDs reduced the activity of complex I (30 mmol/l metformin, −15 ± 2%; 100 μmol/l rosiglitazone, −54 ± 7; and 100 μmol/l pioglitazone, −12 ± 4; P < 0.05 each). Inhibition of complex I was confirmed by reduced state 3 respiration of isolated mitochondria consuming glutamate + malate as substrates for complex I (30 mmol/l metformin, −77 ± 1%; 100 μmol/l rosiglitazone, −24 ± 4; and 100 μmol/l pioglitazone, −18 ± 5; P < 0.05 each), whereas respiration with succinate feeding into complex II was unaffected. In line with inhibition of complex I, 24-h exposure of isolated rat soleus muscle to metformin or TZDs reduced cell respiration and increased anaerobic glycolysis (glucose oxidation: 270 μmol/l metformin, −30 ± 9%; 9 μmol/l rosiglitazone, −25 ± 8; and 9 μmol/l pioglitazone, −45 ± 3; lactate release: 270 μmol/l metformin, +84 ± 12; 9 μmol/l rosiglitazone, +38 ± 6; and 9 μmol/l pioglitazone, +64 ± 11; P < 0.05 each). As both metformin and TZDs inhibit complex I activity and cell respiration in vitro, similar mitochondrial actions could contribute to their antidiabetic effects.

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Metadata

Authors
Brunmair, B., Staniek, K., Gras, F., Scharf, N., Althaym, A., Clara, R., Roden, M., Gnaiger, E., Nohl, H., Waldhäusl, W., & Fürnsinn, C.
Affiliations
  • University of Vienna (AT)
  • University of Veterinary Medicine Vienna (AT)
  • Universität Innsbruck (AT)
  • Department of Medicine III, Division of Endocrinology & Metabolism, University of Vienna, Vienna, Austria
ORCID
Venue
Diabetes
Publisher
American Diabetes Association
Published
2004-04-01
Volume
53
Issue
4
Pages
1052-1059
ISSN
  • 0012-1797 (ISSN-L)
  • 1939-327X
DOI
10.2337/diabetes.53.4.1052
OpenAlex
W2403578638
Cited by
521
References
39
Citations by year
2026: 6 · 2025: 9 · 2024: 15 · 2023: 10 · 2022: 14 · 2021: 15 · 2020: 33 · 2019: 25 · 2018: 16 · 2017: 27 · 2016: 37 · 2015: 30 · 2014: 40 · 2013: 33 · 2012: 29
FWCI
7.64
Type
journal article
Language
en
Open access
Locations
  • Diabetes (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Pfizer
  • Austrian Science Fund
  • Universität Wien
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
Keywords
thiazolidinediones, metformin, mitochondrial complex I, mitochondrial respiration, rosiglitazone, pioglitazone, skeletal muscle, anaerobic glycolysis, glucose oxidation, lactate release, antidiabetic mechanism, type 2 diabetes
MeSH terms
Rosiglitazone, Pioglitazone, Animals, Energy Metabolism, Hypoglycemic Agents, Male, Metformin, Mitochondria, Oxygen Consumption, Potassium Chloride, Rotenone, Rats, Sprague-Dawley, Muscle, Skeletal, Electron Transport Complex I, Thiazolidinediones, Rats

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