The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Protection of Cardiac Mitochondria by Overexpression of MnSOD Reduces Diabetic Cardiomyopathy
Open accessAbstract
We previously reported damage and elevated biogenesis in cardiac mitochondria of a type 1 diabetic mouse model and proposed that mitochondria are one of the major targets of oxidative stress. In this study, we targeted overexpression of the mitochondrial antioxidant protein manganese superoxide dismutase (MnSOD) to the heart to protect cardiac mitochondria from oxidative damage. Transgenic hearts had a 10- to 20-fold increase in superoxide dismutase (SOD) activity, and the transgenic SOD was located in mitochondria. The transgene caused a twofold increase in cardiac catalase activity. MnSOD transgenic mice demonstrated normal cardiac morphology, contractility, and mitochondria, and their cardiomyocytes were protected from exogenous oxidants. Crossing MnSOD transgenic mice with our type 1 model tested the benefit of eliminating mitochondrial reactive oxygen species. Overexpression of MnSOD improved respiration and normalized mass in diabetic mitochondria. MnSOD also protected the morphology of diabetic hearts and completely normalized contractility in diabetic cardiomyocytes. These results showed that elevating MnSOD provided extensive protection to diabetic mitochondria and provided overall protection to the diabetic heart.
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Cites
Normalizing mitochondrial superoxide production blocks three pathways of hyperglycaemic damage
Nishikawa, T., Edelstein, D., Du, X. L., Yamagishi, S.-I., Matsumura, T., Kaneda, Y., Yorek, M. A., Beebe, D., Oates, P. J., Hammes, H.-P., et al. (2000) · Nature · doi:10.1038/35008121 · Cited by 4,277
Cardiac mitochondrial damage and biogenesis in a chronic model of type 1 diabetes
Shen, X., Zheng, S., Thongboonkerd, V., Xu, M., Pierce, W. M., Klein, J. B., & Epstein, P. N. (2004) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00047.2004 · Cited by 258
Self-citationOverexpression of Metallothionein Reduces Diabetic Cardiomyopathy
Liang, Q., Carlson, E. C., Donthi, R. V., Kralik, P. M., Shen, X., & Epstein, P. N. (2002) · Diabetes · doi:10.2337/diabetes.51.1.174 · Cited by 182
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Cited by
Oxidative stress and diabetic complications
Giacco, F., & Brownlee, M. (2010) · Circulation Research · doi:10.1161/circresaha.110.223545 · Cited by 5,461
Diabetic Cardiomyopathy Revisited
Boudina, S., & Abel, E. D. (2007) · Circulation · doi:10.1161/circulationaha.106.679597 · Cited by 1,543
Mitochondrial dysfunction and oxidative stress in heart disease
Peoples, J. N., Saraf, A., Ghazal, N., Pham, T. T., & Kwong, J. Q. (2019) · Experimental & Molecular Medicine · doi:10.1038/s12276-019-0355-7 · Cited by 950
Molecular mechanisms of diabetic cardiomyopathy
Bugger, H., & Abel, E. D. (2014) · Diabetologia · doi:10.1007/s00125-014-3171-6 · Cited by 903
Tan, Y., Zhang, Z., Zheng, C., Wintergerst, K. A., Keller, B. B., & Cai, L. (2020) · Nature Reviews Cardiology · doi:10.1038/s41569-020-0339-2 · Cited by 835
Metadata
- Authors
- Shen, X., Zheng, S., Metreveli, N. S., & Epstein, P. N.
- Venue
- Diabetes
- Publisher
- American Diabetes Association
- Published
- 2006-03-01
- Volume
- 55
- Issue
- 3
- Pages
- 798-805
- ISSN
- 0012-1797 (ISSN-L)
- 1939-327X
- OpenAlex
- W2146302436
- Cited by
- 378
- References
- 3
- FWCI
- 6.51
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Shen, X., Zheng, S., Metreveli, N. S., & Epstein, P. N. (2006). Protection of Cardiac Mitochondria by Overexpression of MnSOD Reduces Diabetic Cardiomyopathy. Diabetes. https://doi.org/10.2337/diabetes.55.03.06.db05-1039
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