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Cited by 315Gestational Diabetes Research and ManagementDiabetes Management and ResearchBirth, Development, and Health

The DOI matches its Crossref record; 24 of the 24 references it cites were found in a registry or an index.

Relationship of Fetal Macrosomia to Maternal Postprandial Glucose Control During Pregnancy

Combs, C Andrew, Gunderson, Erica, Kitzmiller, John L, Gavin, Laurence A, Main, Elliot K·1992·Diabetes Care
DOI 10.2337/diacare.15.10.1251
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Abstract

OBJECTIVE: To determine the gestational ages at which maternal hyperglycemia is most closely related to fetal macrosomia; to determine whether macrosomia is related to elevations of fasting glucose, postprandial glucose, or both; and to assess the relationship of macrosomia to maternal insulin dose and caloric intake. RESEARCH DESIGN AND METHODS: One hundred eleven consecutive pregnant women with Class B through RF diabetes were studied longitudinally from 13 to 36 wk gestation. Macrosomia was defined by birthweight greater than 90th percentile for gestational age based on California norms. Women who delivered macrosomic infants were compared with those without macrosomic infants on pre- and postprandial blood glucose, GHb, insulin dose, macronutrient intake, and several other maternal variables. RESULTS: Macrosomia occurred in 32 (29%) cases, although several measures indicated reasonable glycemic control throughout pregnancy. Women delivering macrosomic infants did not differ from those without macrosomic infants in maternal age, prepregnant weight, duration of diabetes, White class, macronutrient intake, GHb, or fasting glucose. Macrosomia was associated with higher postprandial glucose levels up to 32 wk gestation and lower insulin doses from 29 to 36 wk gestation. In multiple logistic regression, macrosomia was significantly associated with postprandial glucose only between 29 and 32 wk gestation. Postprandial glucose values less than 7.3 mM (less than 130 mg/dl) were associated with a higher risk of small-for-gestational-age infants (18%) compared with values above this level (1%). CONCLUSIONS: Because macrosomia was related to postprandial glucose but not fasting glucose, we conclude that postprandial glucose measurement should be a part of routine care for diabetes in pregnancy. A target 1-h postprandial glucose value of 7.3 mM (130 mg/dl) may be the level that optimally reduces the incidence of macrosomia without increasing the incidence of small-for-gestational-age infants.

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Crossref · 10.2337/diacare.15.10.1251

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Metadata

Authors
Combs, C. A., Gunderson, E., Kitzmiller, J. L., Gavin, L. A., & Main, E. K.
Affiliations
University of California, San Francisco (US)
ORCID
Venue
Diabetes Care
Publisher
American Diabetes Association
Published
1992-10-01
Volume
15
Issue
10
Pages
1251-1257
ISSN
  • 0149-5992 (ISSN-L)
  • 1935-5548
DOI
10.2337/diacare.15.10.1251
OpenAlex
W2027920062
Cited by
315
References
24
Citations by year
2026: 1 · 2025: 12 · 2024: 6 · 2023: 4 · 2022: 13 · 2021: 15 · 2020: 10 · 2019: 10 · 2018: 17 · 2017: 5 · 2016: 9 · 2015: 9 · 2014: 9 · 2013: 12 · 2012: 7
FWCI
7.34
Type
journal article
Language
en
Open access
closed
Locations
  • Diabetes Care (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Obstetrics and Gynecology › Gestational Diabetes Research and Management
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
Keywords
macrosomia, maternal hyperglycemia, postprandial blood glucose, fasting blood glucose, gestational diabetes mellitus, insulin dose, energy intake, glycemic control, HbA1c, small for gestational age, birth weight, gestational age
MeSH terms
Adult, Analysis of Variance, Birth Weight, Blood Glucose, Energy Intake, Diet, Diabetic, Eating, Female, Fetal Macrosomia, Gestational Age, Humans, Infant, Newborn, Insulin, Maternal Age, Pregnancy, Pregnancy in Diabetics, Incidence

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