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Cited by 206Diabetes, Cardiovascular Risks, and LipoproteinsBlood Pressure and Hypertension StudiesDiabetes Treatment and Management

The DOI matches its Crossref record.

Metformin Improves Glucose, Lipid Metabolism, and Reduces Blood Pressure in Hypertensive, Obese Women

Giugliano, Dario, De Rosa, Nicoletta, Di Maro, Giosuè, Marfella, Raffaele, Acampora, Rita, Buoninconti, Raffaello, D'Onofrio, Felice·1993·Diabetes Care
DOI 10.2337/diacare.16.10.1387
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Abstract

OBJECTIVE: To determine the effects of metformin on blood pressure, left ventricular mass, and some metabolic and endocrine parameters in nondiabetic, obese, hypertensive women. RESEARCH DESIGN AND METHODS: Twelve obese, nondiabetic, hypertensive women received 850 mg metformin 2 times/day for 12 wk and placebo for another 12 wk, according to a double-blind, cross-over, randomized design. All patients were hospitalized 4 times, i.e., before randomization and after each treatment (metformin or placebo), to conduct metabolic and cardiovascular investigations (oral glucose tolerance test, euglycemic clamp associated with indirect calorimetry, and echocardiography). RESULTS: Fasting glucose, HbA1c, fasting and glucose-stimulated insulin, blood pressure and left ventricular mass, cholesterol, triglycerides, and fibrinogen decreased significantly after metformin treatment, whereas high-density lipoprotein cholesterol increased. The improvement in glucose metabolism resulted from increased sensitivity to insulin. CONCLUSIONS: These findings suggest that metformin treatment in obese, nondiabetic, hypertensive women produces a more favorable cardiovascular risk profile.

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Crossref · 10.2337/diacare.16.10.1387

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Metadata

Authors
Giugliano, D., De Rosa, N., Di Maro, G., Marfella, R., Acampora, R., Buoninconti, R., & D'Onofrio, F.
Affiliations
  • University of Campania "Luigi Vanvitelli" (IT)
  • Department of Gerontology and Metabolic Diseases, Second University of Naples Naples, Italy
ORCID
Venue
Diabetes Care
Publisher
American Diabetes Association
Published
1993-10-01
Volume
16
Issue
10
Pages
1387-1390
ISSN
  • 0149-5992 (ISSN-L)
  • 1935-5548
DOI
10.2337/diacare.16.10.1387
OpenAlex
W2039851346
Cited by
206
References
0
Citations by year
2026: 1 · 2022: 2 · 2021: 5 · 2020: 2 · 2019: 9 · 2018: 9 · 2017: 10 · 2016: 8 · 2015: 8 · 2014: 6 · 2013: 10 · 2012: 3
FWCI
5.86
Type
journal article
Language
en
Open access
closed
Locations
  • Diabetes Care (publishedVersion)
  • PubMed (publishedVersion)
  • Archivio Istituzionale della Ricerca - Università degli Studi della Campania "Luigi Vanvitelli" (submittedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
Keywords
metformin, hypertension, obesity, women, glucose metabolism, insulin sensitivity, blood pressure, left ventricular mass, lipid metabolism, cardiovascular risk, non-diabetic patients, fibrinogen, HDL cholesterol
MeSH terms
Blood Glucose, Blood Pressure, Calorimetry, Cholesterol, Double-Blind Method, Echocardiography, Female, Fibrinogen, Glucose Tolerance Test, Glycated Hemoglobin, Humans, Hypertension, Insulin, Metformin, Middle Aged, Obesity, Triglycerides, Glucose Clamp Technique

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