Cited by 268Hormonal and reproductive studiesDiabetes, Cardiovascular Risks, and LipoproteinsOvarian function and disorders

The DOI matches its Crossref record.

Testosterone Concentrations in Women and Men With NIDDM

Andersson, Björn, Märin, Per, Lissner, Lauren, Vermeulen, Alex, Björntorp, Per·1994·Diabetes Care

DOI 10.2337/diacare.17.5.405

Open this paper in CoChat — free account

Abstract

UNLABELLED: OBJECTIVE--To evaluate androgen concentrations in relation to insulin resistance in men and women with and without NIDDM. Recent studies have indicated the potential importance of the regulation of insulin sensitivity by androgens in both women and men. Low sex hormone binding globulin (SHBG) concentration is an independent risk factor for the development of non-insulin-dependent diabetes mellitus (NIDDM) in women and is strongly associated statistically with signs of insulin resistance. RESEARCH DESIGN AND METHODS--We compared measurements of anthropometric variables and SHBG, steroid hormone, and insulin concentrations of women and men who have NIDDM with those of control subjects. RESULTS--Women with NIDDM had somewhat higher plasma insulin concentrations, lower SHBG, and higher free testosterone values than did control subjects with similar body mass index (BMI). Women with NIDDM had marginally higher waist-to-hip ratios (WHR). Plasma insulin concentrations correlated positively with BMI, WHR, and free testosterone and negatively with SHBG. In multivariate analyses, insulin concentrations remained positively associated with BMI and free testosterone. Men with NIDDM had higher fasting plasma insulin concentrations than did the nondiabetic control subjects. Testosterone and SHBG were lower in the diabetic men than in both control groups. The derived value of free testosterone was not different between groups. Univariate correlation analyses revealed tight statistical couplings between plasma insulin on the one hand and SHBG and testosterone concentrations (negative) on the other. In multivariate analyses, only the insulin-testosterone association remained. CONCLUSIONS: Women with NIDDM have high levels of free testosterone and low levels of SHBG. Insulin resistance is closely correlated with these signs of hyperandrogenicity as well as with obesity. Men with NIDDM also have low levels of SHBG and, in contrast to women, low testosterone values. Insulin values correlate negatively with these hormonal factors. Based on the results of experimental work and intervention studies, we suggest that these androgen abnormalities might be causally related to insulin resistance in NIDDM.

Integrity signals

Registry

Crossref · 10.2337/diacare.17.5.405

Cites

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Sorted by citations

Items 101–200 of 268

Relationships between dehydroepiandrosterone‐sulphate and anthropometric, metabolic and hormonal variables in a large cohort of obese women
Maccario, M., Mazza, E., Ramunni, J., Oleandri, S. E., Savio, P., Grottoli, S., Rossetto, R., Massimo, P., Gauna, C., & Ghigo, E. (1999) · Clinical Endocrinology · doi:10.1046/j.1365-2265.1999.00692.x · Cited by 49
“, 1991) and reduced in obese women with type 2 diabetes mellitus (Andersson et al., 1994).”
Background
Mechanisms of obesity-induced male infertility
Phillips, K. P., & Tanphaichitr, N. (2010) · Expert Review of Endocrinology & Metabolism · doi:10.1586/eem.09.65 · Cited by 51
Negative Impact of Testosterone Deficiency and 5α-Reductase Inhibitors Therapy on Metabolic and Sexual Function in Men
Traish, A. M. (2017) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-70178-3_22 · Cited by 50
The Endocrine System in Diabetes Mellitus
Alrefai, H., Allababidi, H., Levy, S., & Levy, J. (2002) · Endocrine · doi:10.1385/endo:18:2:105 · Cited by 52
Understanding the new and evolving profile of adverse drug effects in schizophrenia
Wirshing, D. A., Pierre, J. M., Erhart, S. M., & Boyd, J. (2003) · Psychiatric Clinics of North America · doi:10.1016/s0193-953x(02)00035-7 · Cited by 44
Abnormal Cytokine and Adrenocortical Hormone Regulation in Myotonic Dystrophy
Johansson, Å., Carlström, K., Åhrén, B., Cederquist, K., Krylborg, E., Forsberg, H., & Olsson, T. (2000) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.85.9.6794 · Cited by 48
“Testosterone and SHBG levels are decreased in male individuals with the metabolic syndrome, obesity, and/or type II diabetes ( 50 , 51).”
Background
Benefits and Health Implications of Testosterone Therapy in Men With Testosterone Deficiency
Traish, A. M. (2017) · Sexual Medicine Reviews · doi:10.1016/j.sxmr.2017.10.001 · Cited by 46
Effects of bovine prostate powder on zinc, glucose, and insulin metabolism in old patients with non—insulin-dependent diabetes mellitus
Song, M., Rosenthal, M. J., Naliboff, B. D., Phanumas, L., & Kang, K.-W. (1998) · Metabolism · doi:10.1016/s0026-0495(98)90190-1 · Cited by 42
Sex Differences in Diabetes- and TGF-β1-Induced Renal Damage
Ziller, N., Kotolloshi, R., Esmaeili, M., Liebisch, M., Mrowka, R., Baniahmad, A., Liehr, T., Wolf, G., & Loeffler, I. (2020) · Cells · doi:10.3390/cells9102236 · Cited by 39
“This is consistent with several studies reporting that testosterone deficiency is common in men with diabetes [44–50].”
Result
Impact of Glyphosate on the Development of Insulin Resistance in Experimental Diabetic Rats: Role of NFκB Signalling Pathways
Prasad, M., Gatasheh, M. K., Alshuniaber, M. A., Krishnamoorthy, R., Rajagopal, P., Krishnamoorthy, K., Vijayalakshmi, P., Veeraraghavan, V. P., & Jayaraman, S. (2022) · Antioxidants · doi:10.3390/antiox11122436 · Cited by 40
“Additionally, insulin resistance is linked to the castration of male rats, and the condition is corrected with subsequent testosterone replacement, demonstrating the connection between testosterone insufficiency and diabetes [17].”
Background
Hypogonadotrophic hypogonadism in type 2 diabetes
Dandona, P., Dhindsa, S., Chaudhuri, A., Bhatia, V., & Topiwala, S. (2008) · The Aging Male · doi:10.1080/13685530802317934 · Cited by 38
“also found low T and SHBG concentrations in male T2D [10].”
Background
Neuroendocrine mechanisms in insulin resistance
Sjöstrand, M., & Eriksson, J. G. (2008) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2008.05.010 · Cited by 37
Incidence and risk of anemia in type-2 diabetic patients in the absence of renal impairment
Adejumo, B. I. G., Dimkpa, U., Ewenighi, C. O., et al. (2012) · Health · doi:10.4236/health.2012.46050 · Cited by 38
“Our findings indicated that patients who have poorly controlled diabetes were at greater risk of anemia than those with controlled diabetes.”
Background
Does androgen excess contribute to the cardiovascular risk profile in postmenopausal women with type 2 diabetes?
Korytkowski, M. T., Krug, E. I., Daly, M. A., DeRiso, L., Wilson, J. W., & Winters, S. J. (2005) · Metabolism · doi:10.1016/j.metabol.2005.06.011 · Cited by 38
Male hypogonadism: More than just a low testosterone
Pantalone, K. M., & Faiman, C. (2012) · Cleveland Clinic Journal of Medicine · doi:10.3949/ccjm.79a.11174 · Cited by 38
Testosterone is associated with self-employment among Australian men
Greene, F. J., Han, L., Martin, S., Zhang, S., & Wittert, G. (2014) · Economics & Human Biology · doi:10.1016/j.ehb.2013.02.003 · Cited by 36
Androgen deficiency and mitochondrial dysfunction: implications for fatigue, muscle dysfunction, insulin resistance, diabetes, and cardiovascular disease
Traish, A. M., Abdallah, B., & Yu, G. W. (2011) · Hormone Molecular Biology and Clinical Investigation · doi:10.1515/hmbci.2011.132 · Cited by 37
Testosterone Levels in Males with Type 2 Diabetes and Their Relationship with Cardiovascular Risk Factors and Cardiovascular Disease
Hernández‐Mijares, A., García-Malpartida, K., Solá-Izquierdo, E., Bañuls, C., Rocha, M., Gómez-Martínez, M. J., Mármol, R., & Víctor, V. M. (2010) · The Journal of Sexual Medicine · doi:10.1111/j.1743-6109.2010.01705.x · Cited by 36
Exercise training-induced triglyceride lowering negatively correlates with DHEA levels in men with type 2 diabetes
Boudou, P., de Kerviler, É., Erlich, D., Vexiau, P., & Gautier, J. (2001) · International Journal of Obesity · doi:10.1038/sj.ijo.0801637 · Cited by 37
Modelling female physiology from head to Toe: impact of sex hormones, menstrual cycle, and pregnancy
Abo, S., Smith, D., Stadt, M., & Layton, A. (2022) · Journal of Theoretical Biology · doi:10.1016/j.jtbi.2022.111074 · Cited by 35
Hypogonadotropic Hypogonadism in Erectile Dysfunction Associated with Type 2 Diabetes Mellitus: A Common Defect?
Tripathy, D., Dhindsa, S., Garg, R., Khaishagi, A., Syed, T., & Dandona, P. (2003) · Metabolic Syndrome and Related Disorders · doi:10.1089/154041903321648270 · Cited by 34
“Two of the studies do not mention gonadotropin concentrations 16,17 ; one reports increased gonadotropin, 7 while the fourth reports normal LH and FSH. 6 The study showing elevated LH and FSH (hypogonadotropic hypogonadism) was from Pakistan and may represent some distinct underlying pathological…”
Role of Endogenous Androgen Against Insulin Resistance and Athero-sclerosis in Men with Type 2 Diabetes
Fukui, M., Kitagawa, Y., Ose, H., Hasegawa, G., Yoshikawa, T., & Nakamura, N. (2007) · Current Diabetes Reviews · doi:10.2174/157339907779802094 · Cited by 33
“Because men with type 2 diabetes have relative hypogonadism [8,9], supplementation with androgen might reduce both insulin resistance and atherosclerosis.”
Background
Factors predictive of Cutibacterium periprosthetic shoulder infections: a retrospective study of 342 prosthetic revisions
Matsen, F. A., Whitson, A. J., Neradilek, M. B., Pottinger, P. S., Bertelsen, A. L., & Hsu, J. E. (2019) · Journal of Shoulder and Elbow Surgery · doi:10.1016/j.jse.2019.08.008 · Cited by 33
Association Between Serum Bioavailable Testosterone Concentration and the Ratio of Glycated Albumin to Glycated Hemoglobin in Men With Type 2 Diabetes
Fukui, M., Tanaka, M., Hasegawa, G., Yoshikawa, T., & Nakamura, N. (2008) · Diabetes Care · doi:10.2337/dc07-1898 · Cited by 33
Interrelation Between Sex Hormones and Plasma Sex Hormone-Binding Globulin and Hemoglobin A1c in Healthy Postmenopausal Women
Page‐Wilson, G., Goulart, A. C., & Rexrode, K. M. (2009) · Metabolic Syndrome and Related Disorders · doi:10.1089/met.2008.0081 · Cited by 32
“19,20 23 Whereas several studies have examined the relationship between androgenicity and both insulin resistance and diabetes, the infl uence of androgenicity on glycosylated hemoglobin (HbA1c) values has not been analyzed previously in postmenopausal women.”
Testosterone deficiency impairs glucose oxidation through defective insulin and its receptor gene expression in target tissues of adult male rats
Thiruppathi, M., Dhevika, S., Palaniappan, M., & Balasubramanian, K. (2007) · Life Sciences · doi:10.1016/j.lfs.2007.06.009 · Cited by 32
Smoking as a determinant for plasma levels of testosterone, androstenedione, and DHEAs in postmenopausal women
Manjer, J., Johansson, R., & Lenner, P. (2005) · European Journal of Epidemiology · doi:10.1007/s10654-005-0385-4 · Cited by 32
Relationship between low serum endogenous androgen concentrations and arterial stiffness in men with type 2 diabetes mellitus
Fukui, M., Ose, H., Kitagawa, Y., et al. (2007) · Metabolism · doi:10.1016/j.metabol.2007.04.011 · Cited by 31
“Menwith diabetes have significantly lower serum concentrations of endogenous androgens than nondiabetic men [3,4].”
Background
Androgen Deficiency and Phosphodiesterase Type 5 Expression Changes in Aging Male: Therapeutic Implications
Aversa, A., Duca, Y., Condorelli, R. A., Calogero, A. E., & Vignera, S. L. (2019) · Frontiers in Endocrinology · doi:10.3389/fendo.2019.00225 · Cited by 31
The Association of Metabolic Syndrome and Its Components with Serum Prostate-Specific Antigen Levels in a Korean-Screened Population
Jeong, I. G., Hwang, S.-S., Kim, H. K., Ahn, H., & Kim, C. (2010) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-09-0760 · Cited by 30
“Previous studies have shown that men with diabetes have significantly lower serum testosterone concentrations than nondiabetic men (45-48).”
Association of dietary factors and selected plasma variables with sex hormone-binding globulin in rural Chinese women
Gates, J., Parpia, B., Campbell, T. C., & Junshi, C. (1996) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/63.1.22 · Cited by 30
“ciated with a group of chronic degenerative diseases known as Reaven’s syndrome ( 44-46 ).”
Background
Persistence of androgenic effects on the production of proinflammatory cytokines by circulating antigen-presenting cells after withdrawal of testosterone treatment in aging type 2 diabetic men with partial androgen deficiency
Hernández, J. J. C., Almeida, M. D. G., Miralles, J. M., & Órfão, A. (2008) · Fertility and Sterility · doi:10.1016/j.fertnstert.2008.05.040 · Cited by 29
“In addition to monocytes, the following subsets of DC and lymphocytes were identified: [1] myeloid DC (CD33), [2] CD16þ DC (CD33þ, CD14-/dimþ), [3] plasmacytoid DC (CD33-/dimþ) (32, 33), [4] CD4þ/CD8- T cells, [5] CD8þ/ CD4- T lymphocytes, [6] CD4-/CD8- T cells, [7] CD4þ/ CD8þ T lymphocytes, [8] CD4-/CD8þ T cells, [9]…”
Association of increased C-peptide serum levels and testosterone in type 2 diabetes.
Zietz, B., Cuk, A., Hügl, S., Büttner, R., Straub, R., Bauer, B., Daffner, P., Schölmerich, J., & Palitzsch, K. (2000) · European journal of internal medicine · doi:10.1016/s0953-6205(00)00122-9 · Cited by 27
Sex Steroid Hormones in Diabetes-Induced Sexual Dysfunction: Focus on the Female Gender
Kim, N. N. (2009) · The Journal of Sexual Medicine · doi:10.1111/j.1743-6109.2008.01182.x · Cited by 26
Endocrine abnormalities in healthy first‐degree relatives of type 2 diabetes patients – potential role of steroid hormones and leptin in the development of insulin resistance
Jansson, P.-A., Eliasson, B., Lindmark, S., & Eriksson, J. W. (2002) · European Journal of Clinical Investigation · doi:10.1046/j.1365-2362.2002.00963.x · Cited by 26
Relationship between Insulin Resistance, Sex Hormones and Sex Hormone-Binding Globulin in the Serum Lipid and Lipoprotein Profiles of Japanese Postmenopausal Women
Kumagai, S., Kai, Y., & Sasaki, H. (2001) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat1994.8.14 · Cited by 25
Androgen receptor-reduced sensitivity is associated with increased mortality and poorer glycaemia in men with type 2 diabetes mellitus: a prospective cohort study
Heald, A. H., far, G. Y., Livingston, M. A., et al. (2020) · Cardiovascular Endocrinology & Metabolism · doi:10.1097/xce.0000000000000230 · Cited by 24
Sex-Related Aspects in Diabetic Kidney Disease—An Update
Loeffler, I., & Ziller, N. (2023) · Journal of Clinical Medicine · doi:10.3390/jcm12082834 · Cited by 24
Relationship between hepcidin and GDF15 in anemic patients with type 2 diabetes without overt renal impairment
Hong, J. H., Choi, Y., Min, B.-K., Park, K. S., Seong, K., Lee, I. K., & Kim, J. G. (2015) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2015.05.001 · Cited by 24
“[19] Andersson B, Marin P, Lissner L, Vermeulen A, Bjorntorp P.”
Background
Arginase Alteration in the Reproductive System of Alloxan-Diabetic Dogs
Jelodar, G., Razmi, N., & GHOLAMPOUR, V. (2007) · Journal of Reproduction and Development · doi:10.1262/jrd.18049 · Cited by 24
“insulin diabetic patients has been reported to have disordered androgen synthesis [37].”
Background
Association of obesity and diabetes with serum prostate-specific antigen levels in Japanese males.
Naito, M., Asai, Y., Mori, A., et al. (2012) · PubMed · doi:10.18999/nagjms.74.3-4.285 · Cited by 22
Establishing Reference Intervals for DPC’s Free Testosterone Radioimmunoassay
Ooi, D. S., Innanen, V. T., Wang, D., Chong, G., Donnelly, J. G., Arseneault, J., Pronovost, C., & Wells, G. A. (1998) · Clinical Biochemistry · doi:10.1016/s0009-9120(97)00143-4 · Cited by 22
The Evaluation of Serum Levels of Testosterone in Type 2 Diabetic Men and Its Relation with Lipid Profile
Mattack, N. (2015) · JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH · doi:10.7860/jcdr/2015/11049.5381 · Cited by 21
Role of first trimester total testosterone in prediction of subsequent gestational diabetes mellitus
Gözükara, Y., Aytan, H., Ertunç, D., Tok, E. C., Demirtürk, F., Şahin, Ş., & Aytan, P. (2014) · Journal of obstetrics and gynaecology research · doi:10.1111/jog.12525 · Cited by 21
Caffeine Optimizes HIIT Benefits on Obesity-associated Metabolic Adversity in Women
AlKhatib, A. H., Hsieh, M.-J., Kuo, C., & Hou, C. (2020) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0000000000002311 · Cited by 21
“Reported associations in women with diabetes have also documented higher levels of free testosterone and low levels of sex hormone–binding globulin (SHBG), which contrasts those found in diabetic men who demonstrate low levels in both testosterone and SHBG (36).”
BackgroundResult
Andropausa: insuficiência androgênica parcial do homem idoso. Uma revisão
Bonaccorsi, A. C. (2001) · Arquivos Brasileiros de Endocrinologia & Metabologia · doi:10.1590/s0004-27302001000200003 · Cited by 20
Age‐related changes in plasma androgen levels and their association with cardiovascular risk factors in male Japanese office workers
Fukai, S., Akishita, M., Miyao, M., Ishida, K., Toba, K., & Ouchi, Y. (2009) · Geriatrics and gerontology international/Geriatrics & gerontology international · doi:10.1111/j.1447-0594.2009.00552.x · Cited by 20
Do Postmenopausal Women With NIDDM Have a Reduced Capacity to Deposit and Conserve Lower-Body Fat?
Stoney, R. M., Walker, K. Z., Best, J. D., Ireland, P. D., Giles, G. G., & O’Dea, K. (1998) · Diabetes Care · doi:10.2337/diacare.21.5.828 · Cited by 19
“The women with NIDDM were clearly shown to have an androgenic hormone profile, a finding in agreement with previous studies (5,12).”
BackgroundResult
Associations of postmenopausal hormone therapy with metabolic syndrome among diabetic and non-diabetic women
Kim, J.-E., Choi, J., Park, J., Lee, J., Shin, A., Park, S. M., Kang, D., & Choi, J. (2018) · Maturitas · doi:10.1016/j.maturitas.2018.12.012 · Cited by 21
Association between serum prostate-specific antigen level and diabetes, obesity, hypertension, and the laboratory parameters related to glucose tolerance, hepatic function, and lipid profile: implications for modification of prostate-specific antigen threshold
Kobayashi, M., Mizuno, T., Yuki, H., Kambara, T., Betsunoh, H., Nukui, A., Abe, H., Fukabori, Y., Yashi, M., & Kamai, T. (2019) · International Journal of Clinical Oncology · doi:10.1007/s10147-019-01527-6 · Cited by 18
Testosterone therapy in men
Theodoraki, A., & Bouloux, P.-M. G. (2009) · Menopause international · doi:10.1258/mi.2009.009025 · Cited by 17
Male hypogonadism: 14‐year prospective outcome in 550 men with type 2 diabetes
Malipatil, N. S., Yadegarfar, G., Lunt, M., Keevil, B. G., Siddals, K. W., Livingston, M. A., Roberts, S., Narayanan, R. P., Rutter, M. K., Gibson, M., et al. (2019) · Endocrinology Diabetes & Metabolism · doi:10.1002/edm2.64 · Cited by 17
Obesity does not aggravate osteoporosis or osteoblastic insulin resistance in orchiectomized rats
Potikanond, S., Rattanachote, P., Pintana, H., Suntornsaratoon, P., Charoenphandhu, N., Chattipakorn, N., & Chattipakorn, S. C. (2015) · Journal of Endocrinology · doi:10.1530/joe-15-0333 · Cited by 18
Effects of Chronic Exposure to Low Doses of Trichloroethylene on Steroid Hormone and Insulin Levels in Normal Men
Goh, V. H. H., Chia, S. E., & Ong, C. N. (1998) · Environmental Health Perspectives · doi:10.1289/ehp.9810641 · Cited by 20
Revisiting the metabolic syndrome
Chew, G. T., Gan, S. K., & Watts, G. F. (2007) · The Medical Journal of Australia · doi:10.5694/j.1326-5377.2007.tb01132.x · Cited by 16
Glyco-metabolic profile among type 2 diabetic patients with erectile dysfunction
Derosa, G., Tinelli, C., D’Angelo, A., Ferrara, G., Bonaventura, A., Bianchi, L., Romano, D., Fogari, E., & Maffioli, P. (2012) · Endocrine Journal · doi:10.1507/endocrj.ej12-0117 · Cited by 15
“There are also a lot of observational studies that showed a significant inverse relationship between total testosterone and insulin resistance in men [8-11], with a stronger correlation with free testosterone than with total testosterone [12-14].”
Background
Sex-related differences in endothelium-dependent vasodilation of human gingiva
Vág, J., Nagy, T. L., & Mikecs, B. (2022) · BMC Oral Health · doi:10.1186/s12903-022-02186-2 · Cited by 14
Neuronal basis of reproductive dysfunctions associated with diet and alcohol: From the womb to adulthood
Gawałek, M., & Sliwowska, J. H. (2015) · Reproductive Biology · doi:10.1016/j.repbio.2015.04.001 · Cited by 15
Hypogonadism in men with type 2 diabetes
Jones, T. H. (2007) · Practical Diabetes · doi:10.1002/pdi.1117 · Cited by 15
Comparison of serum free testosterone, luteinizing hormone and follicle stimulating hormone levels in diabetics and non-diabetics men- a case-control study.
Rezvani, M. R., Saadatjou, S. A. R., Sorouri, S., & Fard, M. H. (2012) · PubMed · Cited by 15
The effect of continuous combined HRT on glucose homeostasis and plasma lipids
Louise, T., Andersson, B., Glassell, M., & Mattsson, L. (2005) · Maturitas · doi:10.1016/j.maturitas.2005.07.008 · Cited by 13
Self-citation
Testosterone, obesity, diabetes and the metabolic syndrome
Jones, T. H., & Channer, K. S. (2012) · Cambridge University Press eBooks · doi:10.1017/cbo9781139003353.012 · Cited by 13
Maternal Testosterone Levels are Associated with C-Peptide Levels in the Mexican American Subset of the Hyperglycemia and Adverse Pregnancy Outcome (HAPO) Study Cohort
Ackerman, C. M., Lowe, L., Dyer, A. R., Hayes, M. G., Metzger, B. E., Lowe, W. L., Urbanek, M., & for the HAPO Study Cooperative Research Group (2013) · Hormone and Metabolic Research · doi:10.1055/s-0033-1347262 · Cited by 13
Serum Concentrations of .DELTA.5-3.BETA.-Hydroxysteroids in Type 2 Diabetes Mellitus.
Tagawa, N., Ohta, M., Nakamura, N., et al. (2002) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.25.1634 · Cited by 13
Current controversies in testosterone testing: aging and obesity
Elin, R. J., & Winters, S. J. (2004) · Clinics in Laboratory Medicine · doi:10.1016/j.cll.2004.01.010 · Cited by 13
The Use of Hormone Replacement Therapy in Postmenopausal Women with Type 2 Diabetes
Cefalu, W. T. (2001) · Journal of Women s Health & Gender-Based Medicine · doi:10.1089/152460901300139998 · Cited by 13
Effect of Testosterone Replacement Treatment in Testosterone Deficiency Syndrome Patients with Metabolic Syndrome
Jeong, S. M., Ham, B. K., Park, M. G., Oh, M. M., Yoon, D. K., Kim, J. J., & Moon, D. G. (2011) · Korean journal of urology · doi:10.4111/kju.2011.52.8.566 · Cited by 12
“Also, in reverse, many researchers have reported that compared to patients without diabetes mellitus, diabetes mellitus patients have lower testosterone values [15,16].”
Background
Hypersecretion of ovarian androgens may be gonadotrophin dependent many years after menopause
Lindgren, R., Gunnarsson, C., Jakobsson, A., et al. (2000) · Maturitas · doi:10.1016/s0378-5122(99)00092-4 · Cited by 12
“Insulin may not only stimulate ovarian androgen production, but hyperandrogenism may in turn decrease insulin sensitivity [15,16].”
Background
Gaps in the management of diabetes in Asia: A need for improved awareness and strategies in men's sexual health
Wh, K., Sithik, M. N. B. M., Khoo, J. K., Ooi, Y., Lim, Q., & Lim, L. (2022) · Journal of Diabetes Investigation · doi:10.1111/jdi.13903 · Cited by 11
Sex Hormone-Binding Globulin and the Metabolic Syndrome
Hammond, G. L. (2017) · Springer eBooks · doi:10.1007/978-3-319-53298-1_15 · Cited by 13
Sexual Dysfunctions as Self-Reported by Diabetic- Type-2 Men: An Andrology Clinic-Based Study in Alexandria, Egypt
Salama, N. (2013) · American journal of medical and biological research · doi:10.12691/ajmbr-1-3-1 · Cited by 11
“Examples of these may be again related to potential side effects of several medications used by those diabetic men, the change in lifestyle pattern of these men once they were diagnosed with diabetes, the psychological alterations associated with diabetes which have its impact on the patients’ moods together with the…”
Background
Sex-associated differences in clinical outcomes after coronary stenting in patients with diabetes mellitus
Ndrepepa, G., Mehilli, J., Bollwein, H., Pache, J., Schömig, A., & Kastrati, A. (2004) · The American Journal of Medicine · doi:10.1016/j.amjmed.2004.02.036 · Cited by 10
Hyperandrogenemia in Early Adulthood Is an Independent Risk Factor for Abnormal Glucose Metabolism in Middle Age
Tuorila, K., Ollila, M., Järvelin, M., Tapanainen, J. S., Franks, S., Puukka, K. S., Piltonen, T., & Morin-Papunen, L. C. (2021) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgab456 · Cited by 11
“So far, previous studies have explored the relationship between sex steroid hormone levels and T2DM with conflicting results (4, 9, 21-27).”
BackgroundResult
Gender-specific effect of metabolic syndrome on rate adjusted QT interval in middle-aged participants of an atherosclerosis prevention program
Strohmer, B., Schernthaner, C., Iglseder, B., et al. (2007) · Wiener klinische Wochenschrift · doi:10.1007/s00508-007-0840-1 · Cited by 10
“In women, however, insulin resistance has been correlated closely with signs of hyperandrogenicity [28, 29].”
Background
Diabetes Type 2 and Kisspeptin: Central and Peripheral Sex-Specific Actions
Dudek, M., Ziarniak, K., Cateau, M.-L., Dufourny, L., & Sliwowska, J. H. (2019) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2019.07.002 · Cited by 9
The genetics of testosterone contributes to “femaleness/maleness” of cardiometabolic traits and type 2 diabetes
Vosberg, D. E., Parker, N., Shin, J., Pausová, Z., & Paus, T. (2021) · International Journal of Obesity · doi:10.1038/s41366-021-00960-w · Cited by 8
“In females, T2D is associated with higher free testosterone as well as lower SHBG [15].”
BackgroundInfluential
Hormone Replacement Therapy in Postmenopausal Women With Diabetes Mellitus
Andersson, B. R. (2000) · Drugs & Aging · doi:10.2165/00002512-200017050-00006 · Cited by 9
“Interestingly, these women with diabetes mellitus were characterised by relative hyperandrogenicity with low concentrations of SHBG, which is in accordance with a previous report,[35] and improvement of glucose tolerance was most pronounced in those women with most marked hyperandrogenicity.”
ResultSelf-citation
Effect of green coffee supplementation on androgens level in women with polycystic ovary syndrome: A Randomized Clinical Trial
Mousavi, A., Saedisomeolia, A., Yekaninejad, M. S., Ildarabadi, A., Meshkani, M., & Dastjerdi, M. V. (2020) · Obesity Medicine · doi:10.1016/j.obmed.2020.100298 · Cited by 8
The prevalence of hypogonadism in diabetic men in Isfahan Endocrine and Metabolism Research Center, Isfahan, Iran.
Mirzaei, M. R., Amini, M., & Aminorroaya, A. (2012) · Europe PMC (PubMed Central) · Cited by 8
Metabolic syndrome is not associated with markers of subclinical atherosclerosis, serum adiponectin and endogenous androgen concentrations in Japanese men with Type 2 diabetes
Fukui, M., Ose, H., Kitagawa, Y., et al. (2007) · Diabetic Medicine · doi:10.1111/j.1464-5491.2007.02213.x · Cited by 8
Bone stiffness in men with type 2 diabetes mellitus
Asano, M., Fukui, M., Hosoda, H., Shiraishi, E., Harusato, I., Kadono, M., Tanaka, M., Hasegawa, G., Yoshikawa, T., & Nakamura, N. (2008) · Metabolism · doi:10.1016/j.metabol.2008.07.025 · Cited by 9
The loss of alpha-adrenergic effect during the erectile response in the long-term diabetic rat.
MILLS, T. M., Lewis, R. W., Stopper, V. S., et al. (1998) · PubMed · Cited by 8
Gender-Related Behavior during Childhood and Associations with Adult Abdominal Obesity: A Nested Case-Control Study in Women
Rosmond, R., Baghei, F., Holm, G., & Björntorp, P. A. (2000) · Journal of Women s Health & Gender-Based Medicine · doi:10.1089/15246090050020736 · Cited by 8
“2 It has been known for some time that increased circulating levels of androgens are associated with abdominal obesity in women 3–6 and that this relative hyperandro-genicity (HA) is also a risk factor for the development of CVD, 7 DM, 8,9 and premature mortality.”
Self-citation
The Loss of α‐Adrenergic Effect during the Erectile Response in the Long‐Term Diabetic Rat
MILLS, T. M., LEWIS, R. W., Stopper, V. S., et al. (1998) · Journal of Andrology · doi:10.1002/j.1939-4640.1998.tb02041.x · Cited by 8
Management Approaches to Congenital Adrenal Hyperplasia in Adolescents and Adults; Latest Therapeutic Developments
Bahtiyar, G., & Sacerdote, A. S. (2011) · InTech eBooks · doi:10.5772/26350 · Cited by 7
“Both Andersson’s study (Andersson et al., 1994) and ours noted an association between hyperandrogenism and Type 2 DM-an insulin-resistant state.”
Background
Association of Male Infertility to Metabolic Syndrome and Other Related Disorders
Kumar, S., Agrawal, D., Sharma, K. M., & Swain, T. (2015) · Journal of integrative nephrology and andrology · doi:10.4103/2225-1243.168524 · Cited by 7
Testosterone Therapy and Glucose Homeostasis in Men with Testosterone Deficiency (Hypogonadism)
Saad, F. (2017) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-70178-3_23 · Cited by 6
“In men with TD, a marked increase in insulin and glucose levels and reduction in SHBG were recorded (Andersson et al. 1994).”
Background
Human sex hormone-binding globulin does not provide metabolic protection against diet-induced obesity and dysglycemia in mice
Sofer, Y., Nevo, N., Vechoropoulos, M., Shefer, G., Osher, E., Landis, N., Tordjman, K., Hammond, G. L., & Stern, N. (2018) · Endocrine Connections · doi:10.1530/ec-17-0240 · Cited by 6
The occurrence of hypogonadotropic hypogonadism in Chinese men with type 2 diabetes
Zhou, Y., Tian, R., Wang, X., Sun, J., Zhu, L., & An, X. (2022) · Clinical Endocrinology · doi:10.1111/cen.14680 · Cited by 6
Sex Differences in Glucose Homeostasis
Arioglu‐Inan, E., & Kayki‐Mutlu, G. (2023) · Handbook of experimental pharmacology · doi:10.1007/164_2023_664 · Cited by 7
Prevalence of Hypogonadotropic Hypogonadism in Type 2 Diabetes Male Patients
Afkhamizadeh, M., Ghaderian, S. B., Rajabian, R., & Aleali, A. M. (2015) · Open Journal of Endocrine and Metabolic Diseases · doi:10.4236/ojemd.2015.53004 · Cited by 6
Hemoglobin concentration in men with type 2 diabetes mellitus
Harusato, I., Fukui, M., Tanaka, M., et al. (2009) · Metabolism · doi:10.1016/j.metabol.2009.09.028 · Cited by 6
“Men with diabetes have significantly lower serum concentrations of endogenous androgens than nondiabetic men [24,25], which might be one of the factors for the high prevalence of anemia in patients with diabetes [26].”
Background
Relation Between Dietary Calcium and Vitamin D and Risk of Diabetes and Cancer: A Review and Perspective
Noda, M., & Mizoue, T. (2010) · Cited by 6
Düzenli pilates egzersizi yapan kadınlar ile sedanter kadınlarda Y denge testi performansının karşılaştırılması
Ateş, B., & Öztürk, M. A. (2019) · Ege Tıp Bilimleri Dergisi · doi:10.33713/egetbd.510183 · Cited by 6
Early Effect of Metabolic Surgery on Erectile Function and Ejaculation: a Pilot Study of Obese Men with Type 2 Diabetes Mellitus
Karaca, F. C., & Taş, T. (2020) · Obesity Surgery · doi:10.1007/s11695-020-04879-5 · Cited by 6
Correlation of Aging and Body Mass Index with the Hypothalamic-Pituitary-Gonadal Axis Hormones in Men, with Diabetes Mellitus~!2009-11-19~!2010-01-28~!2010-05-05~!
Stanciu, I., Abboud, A., Kellman, W., Williams, D. D., & Azad, N. (2010) · The Open Andrology Journal · doi:10.2174/1876827x01002010006 · Cited by 6
“In addition to aging, diabetes mellitus has also been associated with hypothalamic-pituitary-gonadal (HPG) axis suppression [11-15].”
Background
Serum testosterone and insulin resistance in type 2 male diabetics attending University of Calabar teaching hospital, Nigeria
Agbecha, A., & Usoro, C. (2017) · Journal of Medical Society · doi:10.4103/jms.jms_84_16 · Cited by 6
Endogenous Sex Steroid Hormones, Sex Hormone-Binding Globulin, and Risk of All-Cause and Cause-Specific Mortality: A Systematic Review and Dose-Response Meta-Analysis of Prospective Cohort Studies
Raeisi‐Dehkordi, H., Amiri, M., Beigrezaei, S., Quezada‐Pinedo, H. G., Khatami, F., Alijla, F., Steur, M., Minder, B., Chatelan, A., Voortman, T., et al. (2025) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgaf262 · Cited by 7
Association between serum testosterone concentration and collagen degradation fragments in men with type 2 diabetes mellitus
Fukui, M., Ose, H., Nakayama, I., et al. (2007) · Metabolism · doi:10.1016/j.metabol.2007.04.020 · Cited by 5
“Diabetes is an important consideration here, as men with diabetes have significantly lower plasma concentrations of free and total testosterone than nondiabetic men [28,29].”
Background
Association between Relative Hypogonadism and Metabolic Syndrome in Newly Diagnosed Adult Male Patients with Impaired Glucose Tolerance or Type 2 Diabetes Mellitus
Zou, B., Sasaki, H., & Kumagai, S. (2004) · Metabolic Syndrome and Related Disorders · doi:10.1089/met.2004.2.39 · Cited by 4

Authors: Andersson, B., Märin, P., Lissner, L., Vermeulen, A., & Björntorp, P.
Affiliations: Ghent University Hospital (BE)
Department of Medicine, University Hospital Ghent, Belgium
Sahlgrenska University Hospital (SE)
ORCID: Andersson, Björn
Lissner, Lauren
Vermeulen, Alex
Venue: Diabetes Care
Publisher: American Diabetes Association
Published: 1994-05-01
Volume: 17
Issue: 5
Pages: 405-411
ISSN: 0149-5992 (ISSN-L)
1935-5548
DOI: 10.2337/diacare.17.5.405
OpenAlex: W2087471461
Cited by: 268
References: 0
Citations by year: 2026: 3 · 2025: 5 · 2024: 1 · 2023: 4 · 2022: 8 · 2021: 5 · 2020: 8 · 2019: 11 · 2018: 7 · 2017: 11 · 2016: 8 · 2015: 15 · 2014: 7 · 2013: 6 · 2012: 10
FWCI: 4.10
Type: journal article
Language: en
Open access: closed
Locations: Diabetes Care (publishedVersion)
PubMed (publishedVersion)
Ghent University Academic Bibliography (Ghent University) (submittedVersion)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
Keywords: type 2 diabetes, insulin resistance, free testosterone, sex hormone-binding globulin, androgens, plasma insulin, obesity, waist-to-hip ratio, sex differences
MeSH terms: Androgens, Blood Pressure, Body Weight, Diabetes Mellitus, Type 2, Estradiol, Estrone, Female, Humans, Insulin, Male, Middle Aged, Reference Values, Sex Characteristics, Sex Factors, Sex Hormone-Binding Globulin, Testosterone, Body Mass Index, Multivariate Analysis

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Testosterone Concentrations in Women and Men With NIDDM

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cited by

Related

Metadata

Record

About these checks