The DOI matches its Crossref record.
GHb Is a Better Predictor of Cardiovascular Disease Than Fasting or Postchallenge Plasma Glucose in Women Without Diabetes: The Rancho Bernardo Study
Abstract
OBJECTIVE: To examine the relation between GHb, fasting plasma glucose (FPG), postchallenge plasma glucose (PCPG), and mortality from cardiovascular disease (CVD) and ischemic heart disease (IHD) in older adults. RESEARCH DESIGN AND METHODS: A community-based study of 1,239 nondiabetic older adults followed for an average of 8 years, from baseline (1984–1987) to 1993. RESULTS: GHb, but not FPG or PCPG, was significantly related to CVD and IHD mortality in women but not men. The age-adjusted relative hazard for those in the highest quintile of GHb (≥ 6.7%) compared with women with lower levels was 2.37 for fatal CVD (95% CI = 1.30−4.31, P = 0.005) and 2.43 for IHD (95% CI = 1.12−5.25, P = 0.024). This association persisted after adjustment for all covariates (age, systolic blood pressure, BMI, LDL, HDL, triglycerides, cigarette smoking, antihypertensive medication use, and estrogen use). GHb was significantly associated with LDL and HDL levels in women, but the association between GHb and CVD or IHD persisted after adjustment for these lipoproteins. CONCLUSIONS: We concluded that GHb is a better predictor of CVD and IHD mortality than FPG or PCPG in women without diabetes; no single measure of glycemia was predictive in men. The reason for the sex difference is unexplained.
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“It is important to note that even modest elevations in these biomarkers are associated with adverse outcomes, even when they do not meet accepted thresholds for clinical intervention.21,22”
From Socio‐economic differentials in peripheral biology: Cumulative allostatic load (2010) · cites this paper as [21]
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“Thirteen studies reported postchallenge glucose levels with a variety of glucose loads and sampling times(17-26); 18 reported fasting glucose levels(19,22,24-35); 5 reported casual glucose levels(36-39); and 3 reported glycosylated hemoglobin levels (Table 1).(19,40) The midpoint of the upper blood glucose level categ…”
BackgroundTranslating the Diabetes Prevention Program into the Community
Ackermann, R. T., Finch, E. A., Brizendine, E., Zhou, H., & Marrero, D. G. (2008) · American Journal of Preventive Medicine · doi:10.1016/j.amepre.2008.06.035 · Cited by 622
Metadata
- Authors
- Park, S., Barrett-Connor, E., Wingard, D. L., Shan, J., & Edelstein, S.
- Affiliations
- University of California San Diego (US)
- Venue
- Diabetes Care
- Publisher
- American Diabetes Association
- Published
- 1996-05-01
- Volume
- 19
- Issue
- 5
- Pages
- 450-456
- ISSN
- 0149-5992 (ISSN-L)
- 1935-5548
- OpenAlex
- W2006867892
- Cited by
- 161
- References
- 0
- Citations by year
- 2023: 3 · 2022: 6 · 2020: 5 · 2019: 8 · 2018: 3 · 2017: 2 · 2016: 4 · 2015: 7 · 2014: 7 · 2013: 9 · 2012: 9
- FWCI
- 1.88
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Diabetes Care (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Heart, Lung, and Blood Institute (HL 07491, T35HL007491)
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK031801, DK-31801)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
- Keywords
- HbA1c, cardiovascular mortality, ischemic heart disease mortality, fasting blood glucose, glycemic markers, sex differences, older women, cardiovascular risk prediction
- MeSH terms
- Adult, Age Factors, Blood Glucose, Blood Pressure, California, Cardiovascular Diseases, Fasting, Female, Glucose Tolerance Test, Heart Diseases, Glycated Hemoglobin, Humans, Cholesterol, HDL, Cholesterol, LDL, Male, Middle Aged, Predictive Value of Tests, Reference Values, Risk Factors, Sex Characteristics, Triglycerides, Biomarkers, Body Mass Index, Myocardial Ischemia, Risk Assessment
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