Sex Hormone-Binding Globulin and Glucose Tolerance in Postmenopausal Women: The Rancho Bernardo Study
Abstract
OBJECTIVE: Sex hormone-binding globulin (SHBG) has been shown to be associated with several diabetes risk factors, including total body fat, central obesity, and hyperinsulinemic insulin resistance. We examined the cross-sectional association between SHBG and impaired glucose tolerance (IGT) and NIDDM. RESEARCH DESIGN AND METHODS: We conducted a cross-sectional study including 657 postmenopausal women, aged ≥50 years, who were not using hormone replacement therapy. Blood for SHBG and fasting plasma glucose was obtained concurrently in the morning; all women had a 75-g oral glucose tolerance test and measurement of BMI and waist-to-hip ratio (WHR). RESULTS: SHBG was significantly associated with age, BMI, and WHR but not with smoking, physical activity, or alcohol intake. In these women, SHBG was significantly and independently inversely associated with IGT and with NIDDM. CONCLUSIONS: These data strongly support an association between SHBG, or androgenicity, and diabetes in postmenopausal women. Because of the cross-sectional nature of this study, however, the directionality of the association is uncertain.
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SHBG was found to be negatively associated with plasma glucose, insulin levels and IR.
“In addition, SHBG was also found to be negatively associated with plasma glucose, insulin levels and IR [125–127].”
From Role of sex hormone-binding globulin in the free hormone hypothesis and the relevance of free testosterone in androgen physiology (2022) · cites this paper as [126]
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- Authors
- Goodman-Gruen, D., & Barrett-Connor, E.
- Affiliations
- Department of Family and Preventive Medicine, University of California at San Diego La Jolla, California
- University of California San Diego (US)
- Venue
- Diabetes Care
- Publisher
- American Diabetes Association
- Published
- 1997-04-01
- Volume
- 20
- Issue
- 4
- Pages
- 645-649
- ISSN
- 0149-5992 (ISSN-L)
- 1935-5548
- OpenAlex
- W2064305246
- Cited by
- 87
- References
- 0
- Citations by year
- 2024: 1 · 2023: 2 · 2022: 2 · 2021: 2 · 2020: 1 · 2019: 2 · 2018: 3 · 2016: 2 · 2015: 4 · 2014: 3 · 2013: 3 · 2012: 5
- FWCI
- 1.90
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Diabetes Care (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK031801, DK-31801)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
- Keywords
- sex hormone-binding globulin, impaired glucose tolerance, type 2 diabetes, postmenopausal women, glucose tolerance, androgenic activity, waist-to-hip ratio, body mass index, insulin resistance, diabetes risk factors
- MeSH terms
- Age Factors, Aged, Alcohol Drinking, Anthropometry, Blood Glucose, California, Cross-Sectional Studies, Diabetes Mellitus, Type 2, Fasting, Female, Glucose Tolerance Test, Humans, Middle Aged, Reference Values, Risk Factors, Sex Hormone-Binding Globulin, Smoking, Biomarkers, Exercise, Postmenopause, Glucose Intolerance
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