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Cited by 296Diabetes, Cardiovascular Risks, and LipoproteinsCardiovascular Disease and AdiposityCardiovascular Function and Risk Factors

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Visceral adiposity and incident coronary heart disease in Japanese-American men. The 10-year follow-up results of the Seattle Japanese-American Community Diabetes Study.

Fujimoto, W Y, Bergstrom, R W, Boyko, E J, Chen, K W, Leonetti, D L, Newell-Morris, L, Shofer, J B, Wahl, P W·1999·Diabetes Care
DOI 10.2337/diacare.22.11.1808
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Abstract

OBJECTIVE: To identify risk factors for incident coronary heart disease (CHD). RESEARCH DESIGN AND METHODS: A total of 175 Japanese-American men without CHD were followed for up to 10 years. Baseline variables were blood pressure, weight, BMI, fat areas by computed tomography, skinfold thicknesses, abdominal circumference, plasma insulin, C-peptide, cholesterol, LDL cholesterol, HDL cholesterol, HDL2 cholesterol, and HDL3 cholesterol, triglycerides, apoproteins A1 and B, and diagnosis of diabetes and hypertension. CHD was diagnosed by electrocardiogram and clinical events. Logistic regression was used to estimate odds ratio. RESULTS: There were 50 incident cases of CHD. Using univariate logistic regression analysis, significant risk factors were intra-abdominal fat (P = 0.0090), fasting glucose (P = 0.0002), 2-h glucose (P = 0.0008), fasting HDL cholesterol (P = 0.0086), fasting HDL2 cholesterol (P = 0.030), fasting HDL3 cholesterol (P = 0.018), fasting triglycerides (P = 0.013), systolic (P = 0.0007) and diastolic blood pressure (P = 0.0002), and presence of diabetes (P = 0.0023). Multiple logistic regression models adjusted for BMI and age showed that intra-abdominal fat accounted for the effects of HDL cholesterol or triglycerides. In a multiple logistic regression model that included intra-abdominal fat, all systolic blood pressure and fasting glucose were significant. Substituting diastolic blood pressure for systolic blood pressure and 2-h glucose or diabetes status for fasting glucose produced similar results. CONCLUSIONS: Visceral adiposity, blood pressure, and plasma glucose are important independent risk factors for incident CHD in this population of diabetic and nondiabetic Japanese-American men.

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Metadata

Authors
Fujimoto, W. Y., Bergstrom, R. W., Boyko, E. J., Chen, K. W., Leonetti, D. L., Newell-Morris, L., Shofer, J. B., & Wahl, P. W.
Affiliations
  • University of Washington (US)
  • Department of Medicine, University of Washington, Seattle 98195, USA. wilfuji@u.washington.edu
ORCID
Venue
Diabetes Care
Publisher
American Diabetes Association
Published
1999-11-01
Volume
22
Issue
11
Pages
1808-1812
ISSN
  • 0149-5992 (ISSN-L)
  • 1935-5548
DOI
10.2337/diacare.22.11.1808
OpenAlex
W2105023507
Cited by
296
References
0
Citations by year
2025: 2 · 2024: 8 · 2023: 5 · 2022: 6 · 2021: 7 · 2020: 7 · 2019: 11 · 2018: 16 · 2017: 12 · 2016: 17 · 2015: 8 · 2014: 11 · 2013: 14 · 2012: 17
FWCI
3.00
Type
journal article
Language
en
Open access
closed
Locations
  • Diabetes Care (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Heart, Lung, and Blood Institute (HL 49293, R01HL049293)
  • National Institute of Diabetes and Digestive and Kidney Diseases (DK 31170)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
Keywords
visceral fat, coronary artery disease, Japanese-American men, intra-abdominal fat, HDL cholesterol, HDL2, HDL3 cholesterol, triglycerides, fasting blood glucose, blood pressure, diabetes mellitus, cardiovascular risk factors
MeSH terms
Adipose Tissue, Coronary Disease, Follow-Up Studies, Humans, Japan, Male, Middle Aged, Viscera, Washington, Odds Ratio, Asian People

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