The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
Recovery of cognitive function and mood after severe hypoglycemia in adults with insulin-treated diabetes
Open accessAbstract
OBJECTIVE: Acute hypoglycemia in humans impairs cognitive functions and alters mood states. The time required for cognitive functions and moods to return to normal after an acute episode of severe hypoglycemia is unknown. RESEARCH DESIGN AND METHODS: Cognitive functions and moods were studied prospectively in 20 subjects with insulin-treated diabetes who had recently experienced a spontaneous episode of severe hypoglycemia ("hypo" subjects) and 20 matched control subjects with insulin-treated diabetes who had not experienced severe hypoglycemia during the preceding year. The hypo subjects had a history of a greater number of episodes of severe hypoglycemia (P = 0.000). Cognitive function tests and mood scales were administered at 1.5, 9, and 30 days after the severe hypoglycemia and at similar intervals for the control subjects. RESULTS: For most of the cognitive tests, no evidence of a "hangover" effect of the acute hypoglycemia on cognitive function was observed (P > 0.05). A trend was noted for levels of hedonic tone (P = 0.082) and energetic arousal (P = 0.053) to improve with time in the hypo subjects but not in the control subjects. However, the hypo subjects had chronically elevated levels of depression (P = 0.011) and anxiety (P = 0.049) and persistently performed more poorly in several cognitive tests, such as the Digit Symbol Test (P = 0.009) and the Stroop Task (P = 0.007). CONCLUSIONS: These results suggest that, in general, recovery from any acute cognitive decrement after severe hypoglycemia was complete by 1.5 days. The cognitive decrements and altered mood states noted in the hypo subjects may be persistent and may be a consequence of previous exposure to recurrent episodes of severe hypoglycemia.
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“Patients with recurrent hypoglycemia have been found to have chronic mood disorders including depression and anxiety (85,86), although it is hard to establish cause and effect between hypoglycemia and mood changes.”
From Hypoglycemia and Diabetes: A Report of a Workgroup of the American Diabetes Association and The Endocrine Society (2013) · cites this paper as [86]
In the citing paper
“Patients with recurrent hypoglycemia have been found to have chronic mood disorders including depression and anxiety (85,86), although it is hard to establish cause and effect between hypoglycemia and mood changes.”
From Hypoglycemia and Diabetes: A Report of a Workgroup of the American Diabetes Association and The Endocrine Society (2013) · cites this paper as [86]
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Effects of differing antecedent hypoglycemia on subsequent counterregulation in normal humans
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Changes in mood during acute hypoglycemia in healthy participants.
Gold, A. E., MacLeod, K. M., Frier, B. M., & Deary, I. J. (1995) · Journal of Personality and Social Psychology · doi:10.1037/0022-3514.68.3.498 · Cited by 96
Self-citationVariable Deterioration in Cortical Function During Insulin-induced Hypoglycemia
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Bendtson, I., Gade, J., Theilgaard, A., & Binder, C. (1992) · Diabetologia · doi:10.1007/bf00399939 · Cited by 32
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Roth, J. (2000) · Diabetes/Metabolism Research and Reviews · doi:10.1002/1520-7560(200007/08)16:4
(2015) · Elsevier eBooks · doi:10.1016/b978-0-444-53717-1.00894-5
Mesotten, D., & den Berghe, G. V. (2011) · Elsevier eBooks · doi:10.1016/b978-1-4377-1367-1.00018-5
INSULINS AND OTHER HYPOGLYCEMIC DRUGS
(2009) · Elsevier eBooks · doi:10.1016/b978-0-444-53271-8.50008-9
Insulin, glucagon, and hypoglycemic drugs
Krans, H. M. J. (2001) · Side effects of drugs annual · doi:10.1016/s0378-6080(01)80047-7
ASSESSMENT OF GLYCEMIC CONTROL IN PATIENTS WITH DIABETES MELITUS TYPE I AND DEPRESSION
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Outcome of Acute Injury to the Central Nervous System
Wijdicks, E. F. M. (2023) · doi:10.1093/med/9780197585016.003.0028
The cognitive consequences of hypoglycemia in diabetes
Ancona, N., Rehni, A. K., Mallepalli, S. K. R., & Dave, K. R. (2026) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x261443094
2型糖尿病患者における重低血糖とうつ症状との関連 福岡県糖尿病患者データベース研究
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Roghanizad, M., Choi, E., Mashatan, A., & Turetken, O. (2026) · Behaviour and Information Technology · doi:10.1080/0144929x.2026.2714169
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Findlay, J. A. (2014) · Discovery Research Portal (University of Dundee)
Metadata
- Authors
- Strachan, M. W., Deary, I. J., Ewing, F. M., & Frier, B. M.
- Affiliations
- Edinburgh Royal Infirmary (GB)
- ORCID
- Venue
- Diabetes Care
- Publisher
- American Diabetes Association
- Published
- 2000-03-01
- Volume
- 23
- Issue
- 3
- Pages
- 305-312
- ISSN
- 0149-5992 (ISSN-L)
- 1935-5548
- OpenAlex
- W2107051924
- Cited by
- 113
- References
- 9
- Citations by year
- 2026: 3 · 2025: 1 · 2024: 2 · 2023: 4 · 2022: 2 · 2021: 5 · 2020: 3 · 2019: 3 · 2018: 5 · 2017: 4 · 2016: 8 · 2015: 7 · 2014: 7 · 2013: 6 · 2012: 3
- FWCI
- 2.42
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Diabetes Care (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Education
- Health Sciences › Medicine › Clinical Neurology › Neurological and metabolic disorders
- Keywords
- severe hypoglycemia, cognitive function, mood, insulin-treated diabetes, depression, anxiety, hedonic tone, energetic arousal, recurrent hypoglycemia, Stroop task, digit symbol test
- MeSH terms
- Adult, Affect, Blood Glucose, Cognition, Diabetes Mellitus, Type 1, Female, Humans, Hypoglycemia, Insulin, Intelligence, Male, Memory, Neuropsychological Tests, Time Factors, Wechsler Scales
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