The DOI matches its Crossref record; 36 of the 36 references it cites were found in a registry or an index.
Hypoglycemia Prevalence in Prepubertal Children With Type 1 Diabetes on Standard Insulin Regimen: Use of Continuous Glucose Monitoring System
Open accessAbstract
OBJECTIVE: To determine hypoglycemia prevalence in prepubertal children on thrice (TID) and twice (BID) daily insulin regimens, using the Medtronic Minimed Continuous Glucose Monitoring System. RESEARCH DESIGN AND METHODS: Twenty-eight children aged <12 years (median 9.8, range 6.9-11.8) wore the sensor for three consecutive days and nights. Hypoglycemia was defined as glucose <60 mg/dl for >15 min. Data are expressed as the percentage of time period spent hypoglycemic. RESULTS: Hypoglycemia prevalence was 10.1% (mean 2.6 h. subject(-1) x day(-1)). Hypoglycemia was more common at night compared with daytime (18.81 vs. 4.4%, P < 0.001); 78 and 43% of subjects showed hypoglycemia on at least one night and two or more nights, respectively. Nocturnal episodes were prolonged (median 3.3 h) and asymptomatic (91% of episodes). Prevalence was greater between 0400 and 0730 h than between 2200 and 0400 h (25.5 vs. 15.4%, P < 0.001). On a TID compared with a BID regimen, nocturnal hypoglycemia prevalence was reduced, particularly between 0400-0730 h (22.9 vs. 27.4%, P = 0.005), whereas hypoglycemia the following morning (0730-1200 h) was greater (7.8 vs. 2.8%, P < 0.001). Nocturnal hypoglycemia risk was associated with decreasing age (by a factor of 0.6 for a year less in age), increased insulin dose (by 1.6 for an increase of 0.1 units. kg(-1) x day(-1)), insulin regimen (by 0.2 on a BID compared with a TID regimen), and increased weight standard deviation score (SDS) (by 2.7 for a one SDS rise). CONCLUSIONS: Use of standard insulin regimens results in high prevalence and large intraindividual variation in hypoglycemia, particularly at night. Independent risk factors for nocturnal hypoglycemia were younger age, greater daily insulin dose, insulin regimen, and increasing weight.
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“Around 60–70% of nocturnal hypoglycemic episodes in patients with diabetes occur during late sleep, i.e., between 03:00 and 07:00 h [ 35 , 36 ].”
From Hypoglycemia Unawareness—A Review on Pathophysiology and Clinical Implications (2024) · cites this paper as [36]
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Martin Bland, J., & Altman, D. (1986) · The Lancet · doi:10.1016/s0140-6736(86)90837-8 · Cited by 47,965
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Predictors of Acute Complications in Children With Type 1 Diabetes
Rewers, A. (2002) · JAMA · doi:10.1001/jama.287.19.2511 · Cited by 493
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Limitations of Conventional Methods of Self-Monitoring of Blood Glucose
Boland, E. A., Monsod, T. P., DeLucia, M. C., Brandt, C., Fernando, S. K., & Tamborlane, W. V. (2001) · Diabetes Care · doi:10.2337/diacare.24.11.1858 · Cited by 424
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NORTHAM, E. A., Anderson, P. J., Jacobs, R. K., Hughes, M., Warne, G. L., & Werther, G. A. (2001) · Diabetes Care · doi:10.2337/diacare.24.9.1541 · Cited by 335
Performance Evaluation of the MiniMed® Continuous Glucose Monitoring System During Patient Home Use
Gross, T. M., Bode, B. W., EINHORN, D. F., Kayne, D. M., Reed, J. H. C., White, N. H., & Mastrototaro, J. J. (2000) · Diabetes Technology & Therapeutics · doi:10.1089/152091500316737 · Cited by 304
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Williams, R. M., & Dunger, D. B. (2006) · CRC Press eBooks · doi:10.1201/b14101-73
Qamar, T., Awasthi, S., & Bhriguvanshi, A. (2024) · Journal of the Scientific Society · doi:10.4103/jss.jss_337_23
Analysis of Child Safety Monitoring System using the SPSS Method
(2024) · Journal on Innovations in Teaching and Learning · doi:10.46632/jitl/3/1/3
Fear of Nighttime Hypoglycemia: Perspectives of Diabetes Providers and Caregivers
Monzon, A. D., McDonough, R., Cushing, C. C., Clements, M. A., & Patton, S. R. (2026) · Journal of Clinical Psychology in Medical Settings · doi:10.1007/s10880-026-10158-9
Clinical evaluation of a noninvasive alarm system for nocturnal hypoglycemia
Skladnev, V. N., Ghevondian, N., Tarnavskii, S., Paramalingam, N., & Jones, T. (2010) · UWA Profiles and Research Repository (University of Western Australia)
Metadata
- Authors
- Amin, R., Ross, K., Acerini, C. L., Edge, J. A., Warner, J., & Dunger, D. B.
- Affiliations
- Addenbrooke's Hospital (GB)
- John Radcliffe Hospital (GB)
- Venue
- Diabetes Care
- Publisher
- American Diabetes Association
- Published
- 2003-03-01
- Volume
- 26
- Issue
- 3
- Pages
- 662-667
- ISSN
- 0149-5992 (ISSN-L)
- 1935-5548
- OpenAlex
- W2171347197
- Cited by
- 106
- References
- 36
- Citations by year
- 2026: 1 · 2024: 6 · 2023: 1 · 2021: 2 · 2020: 3 · 2019: 3 · 2018: 1 · 2017: 1 · 2016: 2 · 2015: 4 · 2014: 9 · 2013: 5 · 2012: 7
- FWCI
- 6.51
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Diabetes Care (publishedVersion)
- PubMed (publishedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Funders
- American Diabetes Association
- Novo Nordisk
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Diabetes and associated disorders
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Education
- Keywords
- type 1 diabetes, prepubertal children, nocturnal hypoglycemia, continuous glucose monitoring, insulin regimens, twice-daily insulin, insulin dose, body weight, age, asymptomatic hypoglycemia, hypoglycemia risk factors, time in hypoglycemia, within-person variability
- MeSH terms
- Child, Diabetes Mellitus, Type 1, Female, Glycated Hemoglobin, Humans, Hypoglycemia, Hypoglycemic Agents, Insulin, Male, Risk Factors, Blood Glucose Self-Monitoring, Cohort Studies, Prevalence, Logistic Models
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