Evaluation of Urinary 8-Hydroxydeoxy-Guanosine as a Novel Biomarker of Macrovascular Complications in Type 2 Diabetes
Open accessAbstract
OBJECTIVE—To evaluate urinary 8-hydroxydeoxyguanosine (8-OHdG) as a marker for the progression of diabetic macroangiopathic complications. RESEARCH DESIGN AND METHODS—The content of urinary 8-OHdG, common carotid intima-media thickness (IMT), the coronary heart disease (CHD) risk score, the severity of diabetic retinopathy, and urinary albumin excretion were examined in 96 patients with type 2 diabetes, including 32 patients who had been nominated for the Kumamoto Study [Shichiri M, et al. Diabetes Care 23 (Suppl 2):B21–B29, 2000]. In addition, the patients from the Kumamoto Study were further evaluated regarding the effect of intensive insulin therapy on urinary 8-OHdG excretion. RESULTS—The urinary 8-OHdG:creatinine ratio (U8-OHdG) was 2.5-fold higher in patients with increased HbA1c than in those with normal HbA1c (P < 0.05). In addition, U8-OHdG was 2.3-fold higher in patients with increased IMT (P < 0.005). A similar result was observed between U8-OHdG and CHD risk score (P < 0.01). U8-OHdG was significantly higher in patients with simple retinopathy (P < 0.05) and those with advanced retinopathy (P < 0.01) than in patients without retinopathy. Similarly, U8-OHdG was significantly higher in patients with albuminuria (P < 0.01). Furthermore, in the Kumamoto Study, U8-OHdG was significantly lower in the multiple insulin injection therapy group compared with the conventional insulin injection therapy group (P < 0.01). CONCLUSIONS—Hyperglycemia independently increases 8-OHdG in patients with type 2 diabetes. 8-OHdG is a useful biomarker of not only microvascular but also macrovascular complications in patients with type 2 diabetes.
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Concentrations of 8-iso-PGF2α, MDA, and 8-OHdG are elevated in patients with T2DM compared to healthy controls in both serum and urine.
“Similarly, concentrations of 8-isoprostaglandin F2 α (8-iso-PGF2 α ), malondialdehyde (MDA), and 8-hydroxy-2 0 -deoxyguanosine (8-OHdG) biomarkers have been found to be elevated in patients with T2DM compared to healthy controls in both serum 10 -12 and urine. 13 -15”
From <scp>Glucagon‐like peptide‐1 receptor agonists</scp> improve biomarkers of inflammation and oxidative stress: A systematic review and meta‐analysis of randomised controlled trials (2021) · cites this paper as [15]
The Results (p. 1509–1510) report higher urinary 8-OHdG in subgroups of patients with type 2 diabetes, and the discussion says 8-OHdG increases in patients with diabetes. The paper does not establish the claimed comparison with healthy controls; it measures urinary 8-OHdG, not all three biomarkers in both serum and urine. (LLM, conf=0.85)
Experimental — accuracy not yet measuredWithin T2DM cohorts, higher levels of oxidative stress biomarkers are associated with increased cardiovascular and renal disease risk.
“Furthermore, within T2DM cohorts, higher levels of oxidative stress biomarkers are associated with increased cardiovascular 15 and renal disease risk. 16”
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References 26 · Cited by 190
- Authors
- Nishikawa, T., Sasahara, T., Kiritoshi, S., Sonoda, K., Senokuchi, T., Matsuo, T., Kukidome, D., Wake, N., Matsumura, T., Miyamura, N., Sakakida, M., Kishikawa, H., & Araki, E.
- Affiliations
- Kumamoto University (JP)
- Omuta Tenryo Hospital (JP)
- Kumamoto University Hospital (JP)
- Venue
- Diabetes Care
- Publisher
- American Diabetes Association
- Published
- 2003-05-01
- Volume
- 26
- Issue
- 5
- Pages
- 1507-1512
- ISSN
- 0149-5992 (ISSN-L)
- 1935-5548
- OpenAlex
- W1977164764
- Cited by
- 190
- References
- 26
- Citations by year
- 2026: 3 · 2025: 5 · 2024: 7 · 2023: 4 · 2022: 5 · 2021: 8 · 2020: 9 · 2019: 11 · 2018: 3 · 2017: 13 · 2016: 8 · 2015: 7 · 2014: 8 · 2013: 9 · 2012: 14
- FWCI
- 4.54
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Diabetes Care (publishedVersion)
- PubMed (publishedVersion)
- Funders
- American Diabetes Association
- Uehara Memorial Foundation
- Kanae Foundation for the Promotion of Medical Science
- Japan Diabetes Foundation
- Japan Society for the Promotion of Science (22-26)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Advanced Glycation End Products research
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Nephrology › Chronic Kidney Disease and Diabetes
- Keywords
- 8-hydroxy-2'-deoxyguanosine, urinary biomarkers, type 2 diabetes, macrovascular complications, diabetic macroangiopathy, carotid intima-media thickness, coronary heart disease risk, diabetic retinopathy, albuminuria, intensive insulin therapy, hyperglycemia, oxidative DNA damage
- MeSH terms
- 8-Hydroxy-2'-Deoxyguanosine, Aged, Albuminuria, Creatinine, Deoxyguanosine, Diabetes Mellitus, Type 2, Diabetic Angiopathies, Diabetic Retinopathy, Drug Administration Schedule, Female, Humans, Insulin, Male, Middle Aged, Risk Factors, Biomarkers, Carotid Artery, Common, Tunica Intima, Tunica Media
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