Cited by 791Cardiac Imaging and DiagnosticsCardiovascular Function and Risk FactorsDiabetes, Cardiovascular Risks, and Lipoproteins

The DOI matches its Crossref record; 41 of the 41 references it cites were found in a registry or an index.

Detection of Silent Myocardial Ischemia in Asymptomatic Diabetic Subjects

Open access

Wackers, Frans J.Th., Young, Lawrence H., Inzucchi, Silvio E., Chyun, Deborah A., Davey, Janice A., Barrett, Eugene J., Taillefer, Raymond, Wittlin, Steven D., Heller, Gary V., Filipchuk, Neil, Engel, Samuel, Ratner, Robert E., Iskandrian, Ami E., for the Detection of Ischemia in Asymptomatic Diabetics (DIAD) Investigators·2004·Diabetes Care

DOI 10.2337/diacare.27.8.1954

Open this paper in CoChat — free account Open PDF

Abstract

OBJECTIVE—To assess the prevalence and clinical predictors of silent myocardial ischemia in asymptomatic patients with type 2 diabetes and to test the effectiveness of current American Diabetes Association screening guidelines. RESEARCH DESIGN AND METHODS—In the Detection of Ischemia in Asymptomatic Diabetics (DIAD) study, 1,123 patients with type 2 diabetes, aged 50–75 years, with no known or suspected coronary artery disease, were randomly assigned to either stress testing and 5-year clinical follow-up or to follow-up only. The prevalence of ischemia in 522 patients randomized to stress testing was assessed by adenosine technetium-99m sestamibi single-photon emission–computed tomography myocardial perfusion imaging. RESULTS—A total of 113 patients (22%) had silent ischemia, including 83 with regional myocardial perfusion abnormalities and 30 with normal perfusion but other abnormalities (i.e., adenosine-induced ST-segment depression, ventricular dilation, or rest ventricular dysfunction). Moderate or large perfusion defects were present in 33 patients. The strongest predictors for abnormal tests were abnormal Valsalva (odds ratio [OR] 5.6), male sex (2.5), and diabetes duration (5.2). Other traditional cardiac risk factors or inflammatory and prothrombotic markers were not predictive. Ischemic adenosine-induced ST-segment depression with normal perfusion (n = 21) was associated with women (OR 3.4). Selecting only patients who met American Diabetes Association guidelines would have failed to identify 41% of patients with silent ischemia. CONCLUSIONS—Silent myocardial ischemia occurs in greater than one in five asymptomatic patients with type 2 diabetes. Traditional and emerging cardiac risk factors were not associated with abnormal stress tests, although cardiac autonomic dysfunction was a strong predictor of ischemia.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.2337/diacare.27.8.1954

Cites

41 of 41 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Diabetic Autonomic Neuropathy
Vinik, A. I., Maser, R. E., Mitchell, B. D., & Freeman, R. (2003) · Diabetes Care · doi:10.2337/diacare.26.5.1553 · Cited by 2,044
The Association Between Cardiovascular Autonomic Neuropathy and Mortality in Individuals With Diabetes
Maser, R. E., Mitchell, B. D., Vinik, A. I., & Freeman, R. L. (2003) · Diabetes Care · doi:10.2337/diacare.26.6.1895 · Cited by 678
Influence of Diabetes on 5-Year Mortality and Morbidity in a Randomized Trial Comparing CABG and PTCA in Patients With Multivessel Disease: The Bypass Angioplasty Revascularization Investigation (BARI)
Investigators, T. B. (1997) · Circulation · doi:10.1161/01.cir.96.6.1761 · Cited by 619
Self-administration of a questionnaire on chest pain and intermittent claudication.
Rose, G., McCartney, P., & Reid, D. D. (1977) · Journal of Epidemiology & Community Health · doi:10.1136/jech.31.1.42 · Cited by 584
Treatment of Hypertension in Adults With Diabetes
American Diabetes Association (2003) · Diabetes Care · doi:10.2337/diacare.26.2007.s80 · Cited by 505
Impaired Autonomic Function Is Associated With Increased Mortality, Especially in Subjects With Diabetes, Hypertension, or a History of Cardiovascular Disease
Gerritsen, J., Dekker, J. M., TenVoorde, B. J., Kostense, P. J., Heine, R. J., Bouter, L. M., Heethaar, R. M., & Stehouwer, C. D. A. (2001) · Diabetes Care · doi:10.2337/diacare.24.10.1793 · Cited by 456
Seven-year outcome in the Bypass Angioplasty Revascularization Investigation (BARI) by treatment and diabetic status
The BARI Investigators (2000) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(00)00533-7 · Cited by 443
Coronary Heart Disease in Patients with Diabetes
Haffner, S. M. (2000) · New England Journal of Medicine · doi:10.1056/nejm200004063421408 · Cited by 410
Risk factors that attenuate the female coronary disease advantage
Kannel, W. B. (1995) · Archives of Internal Medicine · doi:10.1001/archinte.1995.00430010063008 · Cited by 381
Impact of Diabetes on the Risk Stratification Using Stress Single-Photon Emission Computed Tomography Myocardial Perfusion Imaging in Patients With Symptoms Suggestive of Coronary Artery Disease
Giri, S., Shaw, L. J., Murthy, D. R., Travin, M. I., Miller, D. D., Hachamovitch, R., Borges-Neto, S., Berman, D. S., Waters, D. D., & Heller, G. V. (2002) · Circulation · doi:10.1161/hc5001.100528 · Cited by 364
Self-citation

Show all 41 references

Sorted by citations

Items 301–400 of 789

Hyperglycemic Crisis in Adults: Pathophysiology, Presentation, Pitfalls, and Prevention
Fowler, M. J. (2009) · Clinical Diabetes · doi:10.2337/diaclin.27.1.19 · Cited by 18
Myocardial perfusion imaging and cardiac events in a cohort of asymptomatic patients with diabetes living in southern France
Sultan, A., Piot, C. A., Mariano‐Goulart, D., Daurès, J., Comte, F., Renard, É., & Avignon, A. (2006) · Diabetic Medicine · doi:10.1111/j.1464-5491.2006.01818.x · Cited by 16
Prognostic value of CT coronary angiography in diabetic and non-diabetic subjects with suspected CAD: importance of presenting symptoms
Maffei, E., Seitun, S., Martini, C., Guaricci, A. I., Tarantini, G., van Pelt, N., Weustink, A. C., Mollet, N. R., Berti, E., Grilli, R. G., et al. (2010) · Insights into Imaging · doi:10.1007/s13244-010-0053-4 · Cited by 18
Value of Electrocardiographic and Ankle–Brachial Index Abnormalities for Prediction of Coronary Atherosclerosis in Asymptomatic Subjects With Type 2 Diabetes Mellitus
Bagheri, R., Schutta, M. H., Cumaranatunge, R. G., Wolfe, M. L., Terembula, K., Hoffman, B., Schwartz, S. J., Kimmel, S. E., Farouk, S. S., Iqbal, N., et al. (2007) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2006.11.040 · Cited by 18
Lessons learned from the detection of ischemia in asymptomatic diabetics (DIAD) study
Wackers, F. J. T., & Young, L. H. (2009) · Journal of Nuclear Cardiology · doi:10.1007/s12350-009-9138-1 · Cited by 18
Self-citation
Imaging Atherosclerosis in Diabetes: Current State
Rahmani, S., Nakanishi, R., & Budoff, M. J. (2016) · Current Diabetes Reports · doi:10.1007/s11892-016-0799-2 · Cited by 18
Coronary atherosclerosis burden by coronary computed tomography in type II diabetes with preclinical non-obstructive carotid atherosclerosis and without inducible myocardial ischemia
Palmieri, V., Gravino, E., Russo, C. A., Salvati, A., Lombardi, C., Sauro, R., & Rosato, G. F. (2016) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2016.11.024 · Cited by 17
Prevalence and Prognostic Importance of Abnormal Positron Emission Tomography Among Asymptomatic Patients With Diabetes Mellitus
Patel, K., Singh, A., Peri-Okonny, P., Patel, F. S., Kennedy, K. F., Sperry, B. W., Thompson, R. C., McGhie, A. I., Spertus, J. A., Shaw, L. J., et al. (2023) · JACC. Cardiovascular imaging · doi:10.1016/j.jcmg.2023.08.010 · Cited by 17
Early detection and significance of structural cardiovascular abnormalities in patients with Type 2 diabetes mellitus
Somaratne, J., WHALLEY, G. A., Bagg, W., & Doughty, R. N. (2007) · Expert Review of Cardiovascular Therapy · doi:10.1586/14779072.6.1.109 · Cited by 15
Microalbuminuria predicts silent myocardial ischaemia in type 2 diabetes patients
Giovacchini, G., Cappagli, M., Carro, S., Borrini, S., Montepagani, A., Leoncini, R., Mazzotta, G., Sambuceti, G., Mariani, G., Volterrani, D., et al. (2013) · European Journal of Nuclear Medicine and Molecular Imaging · doi:10.1007/s00259-012-2323-5 · Cited by 15
Predictors of Physical Inactivity in Men and Women With Type 2 Diabetes From the Detection of Ischemia in Asymptomatic Diabetics (DIAD) Study
McCarthy, M. M., Davey, J. A., Wackers, F. J. T., & Chyun, D. A. (2014) · The Science of Diabetes Self-Management and Care · doi:10.1177/0145721714540055 · Cited by 17
Self-citation
Dysrhythmia and electrocardiographic changes in diabetes mellitus: pathophysiology and impact on the incidence of sudden cardiac death
El-Menyar, A. A. (2006) · Journal of Cardiovascular Medicine · doi:10.2459/01.jcm.0000237904.95882.c8 · Cited by 17
Clinical imaging for prevention: Directed strategies for improved detection of presymptomatic patients with undetected atherosclerosis—Part I: Clinical imaging for prevention
Shaw, L. J., Berman, D. S., Blumenthal, R. S., Budoff, M. J., Faber, T. L., Goraya, T., Halliburton, S. S., Hecht, H. S., Kiat, H., Köenig, W., et al. (2008) · Journal of Nuclear Cardiology · doi:10.1016/j.nuclcard.2007.11.008 · Cited by 17
Importance of the Ankle-Brachial Pressure Index in the Diagnosis of Coronary Artery Disease in Women With Diabetes Without Anginal Pain
Igarashi, Y., Chikamori, T., Hida, S., Tanaka, H., Shiba, C., Usui, Y., Hatano, T., & Yamashina, A. (2011) · Circulation Journal · doi:10.1253/circj.cj-10-1287 · Cited by 16
Sixth Annual Mario S. Verani, MD Memorial Lecture: Cardiovascular imaging—Added value or added cost?
Bonow, R. O. (2008) · Journal of Nuclear Cardiology · doi:10.1016/j.nuclcard.2008.02.006 · Cited by 16
Value of 99mTc-methoxyisobutylisonitrile (99mTc-MIBI) gated SPECT for the detection of silent myocardial ischemia in hemodialysis patients: clinical variables associated with abnormal test results
Çağlar, M., Mahmoudian, B., Aytemir, K., Kahraman, S., Arc, M., Kabakç, G., & Karabulut, E. (2005) · Nuclear Medicine Communications · doi:10.1097/00006231-200601000-00010 · Cited by 16
Interrelationship between myocardial perfusion imaging, coronary calcium score, and endothelial function in asymptomatic diabetics and controls
Peix, A., Cabrera, L. O., Heres, F., Rodríguez, L., Valdés, A., Valiente, J., García, R., Licea, M., Mendoza-Rodríguez, V., Gárciga, F. F. H., et al. (2011) · Journal of Nuclear Cardiology · doi:10.1007/s12350-011-9355-2 · Cited by 16
Myocardial perfusion scintigraphy in asymptomatic diabetic patients: a critical review
Moralidis, E., Didangelos, T., Arsos, G. A., Athyros, V. G., & Mikhailidis, D. P. (2010) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.1098 · Cited by 16
Myocardial Revascularization by Coronary Arterial Bypass Graft: Past, Present, and Future
Greason, K. L., & Schaff, H. V. (2011) · Current Problems in Cardiology · doi:10.1016/j.cpcardiol.2011.05.006 · Cited by 16
Screening for asymptomatic coronary artery disease in patients with type 2 diabetes mellitus
Tavares, C. A. F., Wajchjenberg, B. L., Rochitte, C. E., & Lerário, A. C. (2016) · Archives of Endocrinology and Metabolism · doi:10.1590/2359-3997000000170 · Cited by 18
Prognostic significance of non-chest pain symptoms in patients with non-ST-segment elevation myocardial infarction
Kim, I., Kim, M. C., Park, K. H., Sim, D. S., Hong, Y. J., Kim, J. H., Jeong, M. H., Cho, J. G., Park, J. C., Cho, M., et al. (2017) · The Korean Journal of Internal Medicine · doi:10.3904/kjim.2017.071 · Cited by 16
Assessment of telomerase activity in leukocytes of typeï¿½2 diabetes mellitus patients having or not foot ulcer: Possible correlation with other clinical parameters
Baltzis, D., Meimeti, E., Grammatikopoulou, M. G., Roustit, M., Mavrogonatou, E., Kletsas, D., Efraimidou, S., Manes, C., Νikolouzakis, Τ. Κ., Tsiaoussis, J., et al. (2018) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2018.5798 · Cited by 17
Prevalence and RIsk factors for Silent Myocardial ischemia (PRISM): A clinico observational study in patients of type 2 diabetes
Prasad, D. S., Kabir, Z., Devi, K. R., Peter, P. S., & Das, B. (2019) · Indian Heart Journal · doi:10.1016/j.ihj.2019.12.002 · Cited by 16
High-sensitivity C-reactive protein and silent myocardial ischemia in Chinese with type 2 diabetes mellitus
Hsieh, M., Tien, K., Chang, S., Perng, D., Hsiao, J., Chen, Y., Chang, Y., Kuo, H.-W., & Lin, P.-C. (2008) · Metabolism · doi:10.1016/j.metabol.2008.06.007 · Cited by 16
Simultaneous Pancreas Kidney Transplantation Improves Cardiovascular Autonomic Neuropathy with Improved Valsalva Ratio as the Most Precocious Test
Argente, M., Pérez-Lázaro, A., Martínez-Millana, A., Olmo-García, M. I. D., Espí-Reig, J., Castelló, I. B., López‐Andújar, R., & Merino-Torres, J. F. (2020) · Journal of Diabetes Research · doi:10.1155/2020/7574628 · Cited by 16
Noninvasive Stress Testing for Coronary Artery Disease
Miller, T. D., Askew, J. W., & Anavekar, N. S. (2014) · Cardiology Clinics · doi:10.1016/j.ccl.2014.04.008 · Cited by 16
A randomized study comparing isotope and echocardiography stress testing in the screening of silent myocardial ischaemia in type 2 diabetic patients
Jacqueminet, S., Barthélémy, O., Rouzet, F., Isnard, R., Halbron, M., Bouzamondo, A., Guludec, D. L., Grimaldi, A., Metzger, J., & Feuvre, C. L. (2010) · Diabetes & Metabolism · doi:10.1016/j.diabet.2010.06.005 · Cited by 16
Diabetic Peripheral and Autonomic Neuropathy
Ziegler, D. (2016) · Wiley eBooks · doi:10.1002/9781118924853.ch40 · Cited by 16
Silent myocardial ischemia detected by single photon emission computed tomography (SPECT) and risk of cardiac events among asymptomatic patients with type 2 diabetes: A meta-analysis of prospective studies
Zhang, L., Li, H., Zhang, S., Jaacks, L. M., Li, Y., & Ji, L. (2013) · Journal of Diabetes and its Complications · doi:10.1016/j.jdiacomp.2013.11.013 · Cited by 15
Resting Left Ventricular Global Longitudinal Strain to Identify Silent Myocardial Ischemia in Asymptomatic Patients with Diabetes Mellitus
Albenque, G., Ruşinaru, D., Bellaiche, M., Lena, C. D., Gabrion, P., Delpierre, Q., Malaquin, D., Tribouilloy, C. M., & Bohbot, Y. (2021) · Journal of the American Society of Echocardiography · doi:10.1016/j.echo.2021.10.013 · Cited by 15
Prevalence of Angiographically Defined Obstructive Coronary Artery Disease in Asymptomatic Patients with Type 2 Diabetes According to the Coronary Calcium Score
Leem, J., Koh, E. H., Jeong, E., Jang, J. E., Lee, S., Kang, J., Lim, T., Lee, W. J., Kim, M., Park, J., et al. (2012) · Internal Medicine · doi:10.2169/internalmedicine.51.8221 · Cited by 15
Coronary Artery Disease
Miller, D. D., & Shaw, L. J. (2006) · The Journal of Cardiovascular Nursing · doi:10.1097/00005082-200611001-00002 · Cited by 15
Relationship between glycemic control and coronary artery disease severity, prevalence and plaque characteristics by computed tomography coronary angiography in asymptomatic type 2 diabetic patients
Tavares, C. A. F., Rassi, C. H. R. E., Fahel, M. G., WAJCHENBERG, B. L., Rochitte, C. E., & Lerário, A. C. (2016) · International journal of cardiac imaging · doi:10.1007/s10554-016-0942-9 · Cited by 15
Myocardial perfusion abnormalities in asymptomatic type 2 diabetic patients
Al-Humaidi, G., Sarikaya, İ., Elgazzar, A. H., & Owunwanne, A. (2017) · Journal of the Saudi Heart Association · doi:10.1016/j.jsha.2017.04.006 · Cited by 15
Volume-time curve of cardiac magnetic resonance assessed left ventricular dysfunction in coronary artery disease patients with type 2 diabetes mellitus
Xu, H., Yang, Z.-G., Guo, Y., Shi, K., Liu, X., Zhang, Q., Li, J., & Xie, L. (2017) · BMC Cardiovascular Disorders · doi:10.1186/s12872-017-0583-5 · Cited by 15
Is silent myocardial infarction more common in women with type 2 diabetes than in men?
Stiles, M. C., Seaquist, E. R., Yale, J. F., Green, J. B., Katz, L. A., Kempainen, S., Light, L. S., Pepper, P. V., Zhang, Z.-M., & Soliman, E. Z. (2012) · Journal of Diabetes and its Complications · doi:10.1016/j.jdiacomp.2012.02.002 · Cited by 15
Asymptomatic patients with diabetes mellitus should be screened for coronary artery disease
Wackers, F. J. T. (2006) · Journal of Nuclear Cardiology · doi:10.1016/j.nuclcard.2006.06.129 · Cited by 15
Self-citation
Prognosis of normal stress-only gated-SPECT myocardial perfusion imaging: a single center study
Ferreira, M. J., Cunha, M. J., Albuquerque, A., Moreira, A. P., Ramos, D., Costa, G., Lima, J. P., & Pêgo, M. (2013) · International journal of cardiac imaging · doi:10.1007/s10554-013-0245-3 · Cited by 14
Diabetes mellitus in anaesthesia
Giquel, J., Rodriguez‐Blanco, Y. F., Matadial, C. M., & Candiotti, K. A. (2012) · The British Journal of Diabetes · doi:10.1177/1474651412441223 · Cited by 14
The effect of radial pulse spectrum on the risk of major adverse cardiovascular events in patients with type 2 diabetes
Chang, C., Liao, K., Chang, Y., Wang, S., Chen, Y.-C., & Wang, G. (2018) · Journal of Diabetes and its Complications · doi:10.1016/j.jdiacomp.2018.10.009 · Cited by 15
Relationship between vascular stiffness and stress myocardial perfusion imaging in asymptomatic patients with diabetes
Roos, C. J., Djaberi, R., Schuijf, J. D., de Koning, E. J. P., Rabelink, T. J., Smit, J. W. A., Pereira, A. M., Younis, I. A., van der Hiel, B., Scholte, A. J. H. A., et al. (2011) · European Journal of Nuclear Medicine and Molecular Imaging · doi:10.1007/s00259-011-1894-x · Cited by 14
Ambulatory 24-h ECG monitoring and cardiovascular autonomic assessment for the screening of silent myocardial ischemia in elderly type 2 diabetic hypertensive patients
Bosone, D., Fogari, R., Ramusino, M. C., Ghiotto, N., Guaschino, E., Zoppi, A., D’Angelo, A., & Costa, A. C. (2016) · Heart and Vessels · doi:10.1007/s00380-016-0898-7 · Cited by 14
The changing costs and benefits of screening for asymptomatic coronary heart disease in patients with diabetes
Rutter, M. K., & Nesto, R. W. (2006) · Nature Clinical Practice Endocrinology & Metabolism · doi:10.1038/ncpendmet0352 · Cited by 14
Radionuclide cardiac stress testing
Badheka, A. O., & Hendel, R. C. (2011) · Current Opinion in Cardiology · doi:10.1097/hco.0b013e328349803b · Cited by 14
No Effect of Statin Therapy on Silent Myocardial Ischemia in Patients With Type 2 Diabetes Without Manifest Cardiovascular Disease
Beishuizen, E. D., Jukema, J. W., Tamsma, J. T., van de Ree, M. A., van der Vijver, J. C. M., Putter, H., Maan, A. C., Meinders, A. E., & Huisman, M. V. (2005) · Diabetes Care · doi:10.2337/diacare.28.7.1675 · Cited by 14
Cateterismo cardíaco, diagnóstico (angiografia) e terapêutico (angioplastia) na doença arterial coronária dos pacientes diabéticos
Lima, V. C. (2007) · Arquivos Brasileiros de Endocrinologia & Metabologia · doi:10.1590/s0004-27302007000200020 · Cited by 13
Cardiovascular risk assessment of the diabetic patient undergoing major noncardiac surgery
Hoeks, S. E., Flu, W., van Kuijk, J., Bax, J. J., & Poldermans, D. (2009) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2009.01.002 · Cited by 13
Exercise Stress Testing in Patients With Type 2 Diabetes: When Are Asymptomatic Patients Screened?
Harris, G. D., & White, R. D. (2007) · Clinical Diabetes · doi:10.2337/diaclin.25.4.126 · Cited by 14
Noninvasive Stress Testing for Coronary Artery Disease
Miller, T. D., Askew, J. W., & Anavekar, N. S. (2015) · Heart Failure Clinics · doi:10.1016/j.hfc.2015.08.006 · Cited by 13
Association of ABO blood groups with the severity of coronary artery disease: a cross-sectional study.
Hong, X., Li, Y., Fu, G., Wu, H., Wang, Y., Gu, C., & Zhang, W.-B. (2019) · Europe PMC (PubMed Central) · doi:10.11909/j.issn.1671-5411.2019.09.005 · Cited by 13
Asymptomatic coronary artery disease in type II diabetes.
Baweja, P. S., Sandesara, P. B., & Ashraf, M. J. (2014) · Europe PMC (PubMed Central) · Cited by 13
Coronary artery disease and nuclear imaging in renal failure
Okwuosa, T. M., & Williams, K. A., Sr. (2006) · Journal of Nuclear Cardiology · doi:10.1007/bf02971236 · Cited by 13
Pharmacologic Stress Myocardial Perfusion Imaging
Patel, R. N., Arteaga, R. B., Mandawat, M. K., Thornton, J. W., & Robinson, V. J. B. (2007) · Southern Medical Journal · doi:10.1097/smj.0b013e318153f9c6 · Cited by 13
Identifying which patients with diabetes should be tested for the presence of coronary artery disease – The importance of baseline electrocardiogram and exercise testing
Poirier, P., Després, J., & Bertrand, O. F. (2006) · Canadian Journal of Cardiology · doi:10.1016/s0828-282x(06)70973-4 · Cited by 13
Screening for coronary artery disease in patients with diabetes: A Bayesian strategy of clinical risk evaluation and exercise echocardiography
Rakhit, D. J., Downey, M., Jeffriess, L., Moir, S., Prins, J. B., & Marwick, T. H. (2005) · American Heart Journal · doi:10.1016/j.ahj.2005.01.029 · Cited by 13
Reducing cardiovascular disease in patients with diabetes mellitus
Mazzone, T. (2005) · Current Opinion in Cardiology · doi:10.1097/01.hco.0000166598.29464.20 · Cited by 13
Silent myocardial ischaemia and risk factors in a diabetic Afro-Caribbean population
Blanchet‐Deverly, A., AMARA, M. D. S. S. M. F., Larifla, L., Vélayoudom‐Céphise, F., Roques, F., Kangambega, P., Hue, K., & Foucan, L. (2011) · Diabetes & Metabolism · doi:10.1016/j.diabet.2011.05.006 · Cited by 12
Yield of nuclear scan strategy in chest pain unit evaluation of special populations
Conti, A., Vanni, S., Sammicheli, L., Raveggi, S., Camaiti, A., Pieralli, F., Nozzoli, C., Gallini, C., Costanzo, E. N., & Gensini, G. F. (2008) · Nuclear Medicine Communications · doi:10.1097/mnm.0b013e328310b361 · Cited by 12
Radial Pulse Spectrum Analysis as Risk Markers to Improve the Risk Stratification of Silent Myocardial Ischemia in Type 2 Diabetic Patients
Chang, C., Liao, K., Chen, Y.-C., Wang, S., Jan, M.-Y., & Wang, G. (2018) · IEEE Journal of Translational Engineering in Health and Medicine · doi:10.1109/jtehm.2018.2869091 · Cited by 12
General medical practitioners in Pakistan fail to educate patients adequately about complications of diabetes
Shahpurwala, M., Sani, N., Shah, S., Shuja, F., Shahid, K., Tariq, H., Huda, Z., Zuberi, L. M., Jafar, T., & Jafar, T. H. (2006) · Practical Diabetes · doi:10.1002/pdi.897 · Cited by 12
The report of male gender and retinopathy status improves the current consensus guidelines for the screening of myocardial ischemia in asymptomatic type 2 diabetic patients
Cosson, E., Nguyen, M. T., Chanu, B., Balta, Ş., Takbou, K., & Valensi, P. E. (2012) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2012.01.009 · Cited by 12
Diastolic stress echocardiography detects coronary artery disease in patients with asymptomatic type II diabetes
PARASKEVAIDIS, I. A., Tsougos, E., Panou, F., Dagres, N., Karatzas, D., Boutati, E. I., Varounis, C., & Kremastinos, D. T. (2010) · Coronary Artery Disease · doi:10.1097/mca.0b013e328335a05d · Cited by 12
Relationship between glycosylated hemoglobin A1c and coronary flow reserve in patients with Type 2 diabetes mellitus
Huang, R., Abdelmoneim, S. S., Nhola, L. F., Basu, R., Basu, A., & Mulvagh, S. L. (2015) · Expert Review of Cardiovascular Therapy · doi:10.1586/14779072.2015.1015992 · Cited by 12
Doença arterial coronariana em diabéticas do tipo 2 assintomáticas: estudo comparativo entre o teste ergométrico, o teste cardiopulmonar e a cintilografia de perfusão miocárdica com dipiridamol na identificação de isquemia
Smanio, P. E. P., Carvalho, A. C., Tebexreni, A. S., Thom, A. F., Rodrigues, F. P., Meneghelo, R. S., Mastrocolla, L. E., Alves, A., Piegas, L. S., & de Paola, A. A. (2007) · Arquivos Brasileiros de Cardiologia · doi:10.1590/s0066-782x2007001700003 · Cited by 12
Risk Factors in First Presentation Acute Coronary Syndromes (ACS): How Do We Move From Population to Individualized Risk Prediction?
Saab, F. A., Mukherjee, D., Gurm, H. S., Motivala, A. A., Montgomery, D., Kline-Rogers, E. M., Rubenfire, M., & Eagle, K. A. (2009) · Angiology · doi:10.1177/0003319709333870 · Cited by 12
Fragmented QRS on surface electrocardiogram as a predictor of perfusion defect in patients with suspected coronary artery disease undergoing myocardial perfusion imaging
Hekmat, S., Pourafkari, L., Ahmadi, M., Chavoshi, M., Zamani, B., & Nader, N. D. (2018) · Indian Heart Journal · doi:10.1016/j.ihj.2018.09.011 · Cited by 12
Severity of Cardiovascular Autonomic Neuropathy Is a Predictor Associated With Major Adverse Cardiovascular Events in Adults With Type 2 Diabetes Mellitus: A 6-Year Follow-up Study
Lai, Y., Huang, C., Chang, H., Chiu, W.-C., Tsai, N., Cheng, B., Chen, J., & Lu, C. (2020) · Canadian Journal of Diabetes · doi:10.1016/j.jcjd.2020.06.017 · Cited by 12
The Association between Type-2 Diabetes Duration and Major Adverse Cardiac Events after Percutaneous Coronary Intervention
Benjamin, B. K., Qiu, C., Han, Z., Lu, W., Sun, G., Qin, X., Wang, X., Wang, X., Li, R., & Pan, L. (2021) · Journal of Diabetes Research · doi:10.1155/2021/7580486 · Cited by 12
Prevalence and determinants of silent myocardial ischemia in patients with type 2 diabetes in Cameroon: a cross-sectional study
Mfeukeu‐Kuate, L., Meyanui, V. A., Jingi, A. M., Ndobo-Koé, V., Mballa, F., Gweth, M. N., Etoga, M. C. E., Noubiap, J. J., Sobngwi, E., & Ménanga, A. (2022) · Pan African Medical Journal · doi:10.11604/pamj.2022.42.41.34941 · Cited by 12
NT-pro-BNP is associated with inducible myocardial ischemia in mildly symptomatic type 2 diabetic patients
Wiersma, J. J., van der Zee, P. M., van Straalen, J. P., Fischer, J., van Eck‐Smit, B. L. F., Tijssen, J. G. P., Trip, M. D., Piek, J. J., & Verberne, H. J. (2009) · International Journal of Cardiology · doi:10.1016/j.ijcard.2009.10.035 · Cited by 12
Clinical Outcomes in Metabolic Syndrome
Bhatheja, R., & Bhatt, D. L. (2006) · The Journal of Cardiovascular Nursing · doi:10.1097/00005082-200607000-00011 · Cited by 12
Prognostic value of myocardial perfusion scintigraphy in type 2 diabetic patients with mild, stable angina pectoris
Wiersma, J. J., Verberne, H. J., ten Holt, W. L., Radder, I. M., Dijksman, L. M., van Eck‐Smit, B. L. F., Trip, M. D., Tijssen, J. G. P., & Piek, J. J. (2009) · Journal of Nuclear Cardiology · doi:10.1007/s12350-009-9111-z · Cited by 12
Diabetes Mellitus and Cardiovascular Disease
Chyun, D. A., & Young, L. H. (2006) · Nursing Clinics of North America · doi:10.1016/j.cnur.2006.07.007 · Cited by 12
Self-citation
The role of myocardial perfusion imaging in the diagnosis of patients with coronary artery disease: developments over the past year
Baghdasarian, S. B., & Heller, G. V. (2005) · Current Opinion in Cardiology · doi:10.1097/01.hco.0000174211.16257.31 · Cited by 12
Self-citation
Detectable Subclinical Myocardial Necrosis Is Associated With Cardiovascular Risk in Stable Patients With Diabetes
Tang, W. H. W., Wu, Y., Britt, E. B., Iqbal, N. S., & Hazen, S. L. (2013) · Diabetes Care · doi:10.2337/dc11-1969 · Cited by 12
Symptoms of unstable angina in patients with and without diabetes
DeVon, H. A., Penckofer, S. M., & Zerwic, J. J. (2005) · Research in Nursing & Health · doi:10.1002/nur.20067 · Cited by 12
Preoperative risk evaluation in diabetic patients without angina
Bai, J., Hashimoto, J., Nakahara, T., Kitamura, N., Suzuki, T., & Kubo, A. (2008) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2008.03.013 · Cited by 12
The Association between Left Ventricle Diastolic Dysfunction and Endothelial Dysfunction and the Results of Stress Myocardial SPECT in Asymptomatic Patients with Type 2 Diabetes
Charvat, J., Michalova, K., Chlumský, J., Valenta, Z., & Kvapil, M. (2005) · Journal of International Medical Research · doi:10.1177/147323000503300501 · Cited by 12
Ischemia Dictates Outcome, Not Symptoms
Stone, P. H. (2013) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2012.11.035 · Cited by 12
Prognostic value of myocardial perfusion imaging in patients with known or suspected stable angina pectoris: Evaluation in a setting in which myocardial perfusion imaging did not influence the choice of treatment
Johansen, A. H. D., Høilund‐Carlsen, P. F., Vach, W., Christensen, H. W., Møldrup, M., & Haghfelt, T. H. (2006) · Clinical Physiology and Functional Imaging · doi:10.1111/j.1475-097x.2006.00690.x · Cited by 11
Gender-based divergence of cardiovascular outcomes in asymptomatic patients with type 2 diabetes: Results from the DIAD study
Tandon, S., Wackers, F. J. T., Inzucchi, S. E., Bansal, S., Staib, L. H., Chyun, D. A., Davey, J. A., Young, L. H., & for the DIAD Investigators (2012) · Diabetes and Vascular Disease Research · doi:10.1177/1479164111431470 · Cited by 11
Self-citation
Interpretation of cardiovascular outcome trials in type 2 diabetes needs a multiaxial approach
Johansen, O. E. (2015) · World Journal of Diabetes · doi:10.4239/wjd.v6.i9.1092 · Cited by 11
Exercise as Treatment for Neuropathy in the Setting of Diabetes and Prediabetic Metabolic Syndrome: A Review of Animal Models and Human Trials
Singleton, J. R., Foster-Palmer, S. C., & Marcus, R. L. (2021) · Current Diabetes Reviews · doi:10.2174/1573399817666210923125832 · Cited by 14
Coronary Artery Calcium Screening in Persons with Metabolic Syndrome and Diabetes: Implications for Prevention
Tehrani, D. M., Malik, S., & Wong, N. D. (2013) · Metabolic Syndrome and Related Disorders · doi:10.1089/met.2012.0165 · Cited by 11
Screening Asymptomatic Patients with Type 2 Diabetes Mellitus for Coronary Artery Disease: Does It Improve Patient Outcome?
Shirani, J., & Dilsizian, V. (2010) · Current Cardiology Reports · doi:10.1007/s11886-010-0091-z · Cited by 11
Cardiovascular Disease
Braun, L. T. (2006) · The Journal of Cardiovascular Nursing · doi:10.1097/00005082-200611001-00004 · Cited by 11
Treatment of specific macrovascular beds in patients with diabetes mellitus
Petznick, A. M., & Shubrook, J. H. (2010) · Osteopathic Medicine and Primary Care · doi:10.1186/1750-4732-4-5 · Cited by 10
N‐terminal fragment of pro‐brain natriuretic peptide (NT‐proBNP) for predicting silent myocardial ischaemia in type 2 diabetes mellitus independent of microalbuminuria
Hamano, K., Abe, M., Komi, R., & Kobayashi, S. (2010) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.1113 · Cited by 11
Role of new imaging modalities in pursuit of the vulnerable plaque and the vulnerable patient
Raggi, P., Pontone, G., & Andreini, D. (2017) · International Journal of Cardiology · doi:10.1016/j.ijcard.2017.10.046 · Cited by 11
Appropriate choice of stress modality in patients undergoing myocardial perfusion scintigraphy with a cardiac camera equipped with solid-state detectors: the role of diabetes mellitus
Gimelli, A., Liga, R., Clemente, A., Pasanisi, E., Favilli, B., & Marzullo, P. (2017) · European Heart Journal - Cardiovascular Imaging · doi:10.1093/ehjci/jex313 · Cited by 11
Prediction and early detection of cardiovascular disease in South Asians with diabetes mellitus
Wander, G. S., Bansal, M., & Kasliwal, R. R. (2020) · Diabetes & Metabolic Syndrome Clinical Research & Reviews · doi:10.1016/j.dsx.2020.04.017 · Cited by 12
Holter monitoring for the screening of cardiac disease in diabetes mellitus: The non-invasive Holter monitoring observation of new cardiac events in diabetics study
Nakao, Y. M., Ueshima, K., Nohara, R., 水沼, 吉., Segawa, I., Tanaka‐Mizuno, S., Yasuno, S., Nakao, K., Hiramori, K., & Kihara, Y. (2015) · Diabetes and Vascular Disease Research · doi:10.1177/1479164115595523 · Cited by 11
Correlation of the severity of diabetic retinopathy and the heart muscle perfusion in patients with type 2 diabetes
Tryniszewski, W., Kuśmierczyk, J., Maziarz, Z., Goś, R., Mikhailidis, D. P., Banach, M., Rysz, J., & Pesudovs, K. (2011) · Journal of Diabetes and its Complications · doi:10.1016/j.jdiacomp.2011.02.003 · Cited by 11
Comparison of 64-slice multi-detector computed tomography coronary angiography between asymptomatic, type 2 diabetes mellitus and impaired glucose tolerance patients
Sassa, S., Shimada, K., Yoshida, K., Tanaka, H., Jissho, S., & Yoshikawa, J. (2008) · Journal of Cardiology · doi:10.1016/j.jjcc.2008.06.009 · Cited by 11
Drain Current Centric Modality: Instrumentation and Evaluation of ISFET for Monitoring Myocardial Ischemia Like Variations in pH and Potassium Ion Concentration
Rai, P., Jung, S., Ji, T., & Varadan, V. K. (2009) · IEEE Sensors Journal · doi:10.1109/jsen.2009.2032525 · Cited by 11
Screening asymptomatic patients with type 2 diabetes is recommended: Pro
Petretta, M., & Cuocolo, A. (2015) · Journal of Nuclear Cardiology · doi:10.1007/s12350-015-0250-0 · Cited by 11
Influence of sex on the incidence of potential coronary artery disease and long-term outcomes in asymptomatic patients with diabetes mellitus
Sato, C., Wakabayashi, K., Ikeda, N., Honda, Y., Sato, K., Suzuki, T., Shibata, K., & Tanno, K. (2020) · IJC Heart & Vasculature · doi:10.1016/j.ijcha.2020.100504 · Cited by 11
Retracted: Prediction of Proliferative Diabetic Retinopathy to Asymptomatic Obstructive Coronary Artery Disease in Chinese Type 2 Diabetes Individuals: An Exploratory Study
Zhou, J., Zhu, X.-R., Zhao, W., Yin, L., Li, H., Qi, L., & Yang, J. (2019) · Metabolic Syndrome and Related Disorders · doi:10.1089/met.2018.0140 · Cited by 11
Retracted
Low-dose CT coronary angiography for assessment of coronary artery disease in patients with type 2 diabetes - A cross-sectional study
Ulimoen, G. R., Ofstad, A. P., Endresen, K., Gullestad, L. L., Johansen, O. E., & Borthne, A. (2015) · BMC Cardiovascular Disorders · doi:10.1186/s12872-015-0143-9 · Cited by 10
Comparative roles of cardiac CT and myocardial perfusion scintigraphy in the evaluation of patients with coronary artery disease: Competitive or complementary
Yerramasu, A. K., Lahiri, A., & Chua, T. (2010) · Journal of Nuclear Cardiology · doi:10.1007/s12350-010-9260-0 · Cited by 10

Authors: Wackers, F. J. T., Young, L. H., Inzucchi, S. E., Chyun, D. A., Davey, J. A., Barrett, E. J., Taillefer, R., Wittlin, S. D., Heller, G. V., Filipchuk, N., Engel, S., Ratner, R. E., Iskandrian, A. E., & for the Detection of Ischemia in Asymptomatic Diabetics (DIAD) Investigators
Affiliations: Yale University (US)
University of Virginia (US)
Université de Montréal (CA)
University of Rochester Medicine (US)
Hartford Hospital (US)
Cardiology Consultants, Calgary, Canada
Soundview Research Associates, Norwalk, Connecticut
MedStar Health Research Institute (US)
University of Alabama at Birmingham (US)
ORCID: Inzucchi, Silvio E.
Chyun, Deborah A.
Barrett, Eugene J.
Wittlin, Steven D.
Engel, Samuel
Venue: Diabetes Care
Publisher: American Diabetes Association
Published: 2004-08-01
Volume: 27
Issue: 8
Pages: 1954-1961
ISSN: 0149-5992 (ISSN-L)
1935-5548
DOI: 10.2337/diacare.27.8.1954
OpenAlex: W2159222156
Cited by: 791
References: 41
Citations by year: 2026: 5 · 2025: 12 · 2024: 6 · 2023: 13 · 2022: 15 · 2021: 20 · 2020: 23 · 2019: 28 · 2018: 30 · 2017: 34 · 2016: 34 · 2015: 35 · 2014: 46 · 2013: 51 · 2012: 42
FWCI: 50.56
Type: journal article
Language: en
Update notices: correction (2005-02-01)
Open access: bronze
doi.org
Locations: Diabetes Care (publishedVersion)
PubMed (publishedVersion)
Funders: Yale University
National Center for Research Resources (5-M01-RR-00044, M01RR000125, M01 RR-00125, 5 M01 RR00847, M01RR000044, M01RR000847, 5M01 RR0596)
Topics: Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Cardiac Imaging and Diagnostics
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Keywords: silent myocardial ischemia, type 2 diabetes, asymptomatic patients, coronary artery disease, stress testing, myocardial perfusion imaging, 99mTc-sestamibi, cardiac autonomic dysfunction, Valsalva maneuver, ST-segment depression, diabetes duration, cardiovascular risk factors, prevalence
MeSH terms: Canada, Coronary Disease, Diabetes Mellitus, Type 1, Diabetic Angiopathies, Exercise Test, Female, Humans, Male, Middle Aged, Outpatients, United States, Tomography, Emission-Computed, Single-Photon, Myocardial Ischemia, Technetium Tc 99m Sestamibi, Radiopharmaceuticals

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Detection of Silent Myocardial Ischemia in Asymptomatic Diabetic Subjects

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks