The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Acetyl-l-Carnitine Improves Pain, Nerve Regeneration, and Vibratory Perception in Patients With Chronic Diabetic Neuropathy
Abstract
OBJECTIVE—We evaluated frozen databases from two 52-week randomized placebo-controlled clinical diabetic neuropathy trials testing two doses of acetyl-l-carnitine (ALC): 500 and 1,000 mg/day t.i.d. RESEARCH DESIGN AND METHODS—Intention-to-treat patients amounted to 1,257 or 93% of enrolled patients. Efficacy end points were sural nerve morphometry, nerve conduction velocities, vibration perception thresholds, clinical symptom scores, and a visual analogue scale for most bothersome symptom, most notably pain. The two studies were evaluated separately and combined. RESULTS—Data showed significant improvements in sural nerve fiber numbers and regenerating nerve fiber clusters. Nerve conduction velocities and amplitudes did not improve, whereas vibration perception improved in both studies. Pain as the most bothersome symptom showed significant improvement in one study and in the combined cohort taking 1,000 mg ALC. CONCLUSIONS—These studies demonstrate that ALC treatment is efficacious in alleviating symptoms, particularly pain, and improves nerve fiber regeneration and vibration perception in patients with established diabetic neuropathy.
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Citations
Cites
Increased Prevalence of Impaired Glucose Tolerance in Patients With Painful Sensory Neuropathy
Singleton, J. R., Smith, A. G., & Bromberg, M. B. (2001) · Diabetes Care · doi:10.2337/diacare.24.8.1448 · Cited by 364
Cited by
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Dewanjee, S., Das, S., Das, A. K., Bhattacharjee, N., Dihingia, A., Dua, T. K., Kalita, J., & Manna, P. (2018) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2018.06.034 · Cited by 300
Diabetic neuropathy and oxidative stress
Pop-Busui, R., Sima, A., & Stevens, M. (2006) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.625 · Cited by 286
Self-citationImproving peripheral nerve regeneration: From molecular mechanisms to potential therapeutic targets
Chan, K. M., Gordon, T., Zochodne, D. W., & Power, H. A. (2014) · Experimental Neurology · doi:10.1016/j.expneurol.2014.09.006 · Cited by 189
Alisson-Silva, F., Kawanishi, K., & Varki, A. (2016) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2016.07.002 · Cited by 156
Fan, L., Cacicedo, J. M., & Ido, Y. (2020) · Journal of Diabetes Investigation · doi:10.1111/jdi.13303 · Cited by 86
Metadata
- Authors
- Sima, A. A. F., Calvani, M., Mehra, M., Amato, A., & for the Acetyl-l-Carnitine Study Group
- Venue
- Diabetes Care
- Publisher
- American Diabetes Association
- Published
- 2005-01-01
- Volume
- 28
- Issue
- 1
- Pages
- 89-94
- ISSN
- 0149-5992 (ISSN-L)
- 1935-5548
- OpenAlex
- W2050629341
- Cited by
- 234
- References
- 1
- FWCI
- 9.49
- Type
- journal article
- Language
- en
- Open access
- closed
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- The paper
- Sima, A. A. F., Calvani, M., Mehra, M., Amato, A., & for the Acetyl-l-Carnitine Study Group. (2005). Acetyl-l-Carnitine Improves Pain, Nerve Regeneration, and Vibratory Perception in Patients With Chronic Diabetic Neuropathy. Diabetes Care. https://doi.org/10.2337/diacare.28.1.89
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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