Oral Propranolol and Metoprolol Both Impair Glucose Recovery from Insulin-induced Hypoglycemia in Insulin-dependent Diabetes Mellitus

Popp, Dennis A; Tse, Thomas F; Shah, Suresh D; Clutter, William E; Cryer, Philip E

doi:10.2337/diacare.7.3.243

Oral Propranolol and Metoprolol Both Impair Glucose Recovery from Insulin-induced Hypoglycemia in Insulin-dependent Diabetes Mellitus

To the extent that they have deficient glucagon secretory responses to plasma glucose decrements, as they commonly do, patients with insulin-dependent diabetes mellitus (IDDM) are dependent on epinephrine-mediated β-adrenergic mechanisms to promote recovery from hypoglycemia. Thus, they are at in…