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Biopsychosocial Mechanisms of Chronic Itch in Patients with Skin Diseases: a Review
Open accessAbstract
Itch is a major feature of many skin diseases, which adversely affects patient's quality of life. Besides disease severity, psychophysiological factors have been proposed to influence the itch sensation. In this review the evidence for a biopsychosocial model of itch is described, focusing in particular on evidence for the effects of personality characteristics, external stressors, cognitive, behavioural and social factors, and the possible mediating role of physiological processes. Research so far indicates that stressors may have a role in the itch sensation of patients with skin diseases. Furthermore, cognitive factors, such as helplessness and worrying, and the behavioural response of scratching have been indicated as possible worsening factors. Overall, findings are in favour of a biopsychosocial model for the itch sensation. However, there is a strong need for more, methodologically sound research in order fully to understand the processes underlying the itch sensation.
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“The biopsychosocial model of chronic itch (5) proposes that internal (e.g., personality) and external factors (e.g., stress) can lead to illness cognitions, social reactions, and behaviors, which can increase physiological responses (e.g., activation of certain brain areas) leading to itch (5).”
From Mindfulness as Predictor of Itch Catastrophizing in Patients With Atopic Dermatitis: Results of a Cross-Sectional Questionnaire Study (2021) · cites this paper as [5]
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Metadata
- Authors
- Verhoeven, E. W. M., De Klerk, S., Kraaimaat, F. W., Van de Kerkhof, P. C. M., De Jong, E. M. G. J., & Evers, A. W. M.
- Affiliations
- Radboud University Medical Center (NL)
- Corresponding author
- Verhoeven, Elisabeth W.M.
- Venue
- Acta Dermato Venereologica
- Publisher
- Medical Journals Sweden AB
- Published
- 2008-05-03
- Volume
- 88
- Issue
- 3
- Pages
- 211-218
- ISSN
- 0001-5555 (ISSN-L)
- 1651-2057
- OpenAlex
- W2156055510
- Cited by
- 126
- References
- 104
- Citations by year
- 2026: 6 · 2025: 5 · 2024: 3 · 2023: 6 · 2022: 6 · 2021: 15 · 2020: 15 · 2019: 5 · 2018: 12 · 2017: 3 · 2016: 4 · 2015: 9 · 2014: 7 · 2013: 3 · 2012: 7
- FWCI
- 1.03
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Acta Dermato Venereologica (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Radboud Repository (Radboud University) (submittedVersion)
- Radboud Repository (Radboud University) (submittedVersion, other-oa)
- Topics
- Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
- Health Sciences › Medicine › Psychiatry and Mental health › Psychosomatic Disorders and Their Treatments
- Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
- Keywords
- chronic pruritus, pruritus, skin diseases, biopsychosocial model, stress, personality, helplessness, worry, scratching behavior, cognitive factors, social factors, quality of life
- MeSH terms
- Adaptation, Psychological, Chronic Disease, Helplessness, Learned, Humans, Models, Psychological, Personality, Pruritus, Quality of Life, Skin Diseases, Social Support, Stress, Psychological
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